Clinical frailty assessment might be associated with mortality in incident dialysis patients
Abstract Frailty is associated with mortality in maintenance dialysis patients. For incident dialysis patients, we used the clinical frailty scale (CFS) to investigate frailty as related to mortality or hospitalization within 2 years. We retrospectively reviewed the medical records of patients initi...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-22483-8 |
| _version_ | 1828318357577793536 |
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| author | Rikako Oki Yoshifumi Hamasaki Shiho Tsuji Kana Suzuki Sayaka Tsuneishi Mikie Imafuku Yohei Komaru Yoshihisa Miyamoto Ryo Matsuura Kent Doi Masaomi Nangaku |
| author_facet | Rikako Oki Yoshifumi Hamasaki Shiho Tsuji Kana Suzuki Sayaka Tsuneishi Mikie Imafuku Yohei Komaru Yoshihisa Miyamoto Ryo Matsuura Kent Doi Masaomi Nangaku |
| author_sort | Rikako Oki |
| collection | DOAJ |
| description | Abstract Frailty is associated with mortality in maintenance dialysis patients. For incident dialysis patients, we used the clinical frailty scale (CFS) to investigate frailty as related to mortality or hospitalization within 2 years. We retrospectively reviewed the medical records of patients initiating hemodialysis or peritoneal dialysis during 2016–2018. Based on those records, two dialysis nurses independently used a 9-point CFS (1 = “Very fit” to 9 = “Terminally ill”) to assess each patient’s frailty at dialysis initiation. Patients with a mean CFS value of 5 or higher were classified into the frail group. The 2-year survival rates or hospitalization-free rates after the initiation of dialysis were compared between the frail (mean CFS score ≥ 5) and non-frail (mean CFS score < 5) groups. The analysis included 155 incident dialysis patients with mean age of 66.7 ± 14.1 (71% male). Frailty was inferred for 39 (25%) patients at dialysis initiation. Kaplan–Meier analyses showed that the survival rate and hospitalization-free rate within 2 years were significantly lower in the frail group than in the non-frail group (p < 0.01). Cox proportional hazards regression analyses revealed the CFS score as associated with the occurrence of a composite outcome, independently of age (hazard ratio 1.34, 95% confidence interval 1.04–1.72). Frailty assessment based on clinical judgment using CFS might predict adverse outcomes in dialysis-initiated patients. |
| first_indexed | 2024-04-13T17:41:48Z |
| format | Article |
| id | doaj.art-b18a17c999eb45e2a62154e539004154 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T17:41:48Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b18a17c999eb45e2a62154e5390041542022-12-22T02:37:10ZengNature PortfolioScientific Reports2045-23222022-10-011211910.1038/s41598-022-22483-8Clinical frailty assessment might be associated with mortality in incident dialysis patientsRikako Oki0Yoshifumi Hamasaki1Shiho Tsuji2Kana Suzuki3Sayaka Tsuneishi4Mikie Imafuku5Yohei Komaru6Yoshihisa Miyamoto7Ryo Matsuura8Kent Doi9Masaomi Nangaku10Department of Hemodialysis and Apheresis, The University of Tokyo HospitalDepartment of Hemodialysis and Apheresis, The University of Tokyo HospitalDepartment of Hemodialysis and Apheresis, The University of Tokyo HospitalDepartment of Hemodialysis and Apheresis, The University of Tokyo HospitalDepartment of Hemodialysis and Apheresis, The University of Tokyo HospitalDepartment of Hemodialysis and Apheresis, The University of Tokyo HospitalDepartment of Hemodialysis and Apheresis, The University of Tokyo HospitalDepartment of Hemodialysis and Apheresis, The University of Tokyo HospitalDepartment of Hemodialysis and Apheresis, The University of Tokyo HospitalDepartment of Acute Medicine, The University of Tokyo HospitalDepartment of Hemodialysis and Apheresis, The University of Tokyo HospitalAbstract Frailty is associated with mortality in maintenance dialysis patients. For incident dialysis patients, we used the clinical frailty scale (CFS) to investigate frailty as related to mortality or hospitalization within 2 years. We retrospectively reviewed the medical records of patients initiating hemodialysis or peritoneal dialysis during 2016–2018. Based on those records, two dialysis nurses independently used a 9-point CFS (1 = “Very fit” to 9 = “Terminally ill”) to assess each patient’s frailty at dialysis initiation. Patients with a mean CFS value of 5 or higher were classified into the frail group. The 2-year survival rates or hospitalization-free rates after the initiation of dialysis were compared between the frail (mean CFS score ≥ 5) and non-frail (mean CFS score < 5) groups. The analysis included 155 incident dialysis patients with mean age of 66.7 ± 14.1 (71% male). Frailty was inferred for 39 (25%) patients at dialysis initiation. Kaplan–Meier analyses showed that the survival rate and hospitalization-free rate within 2 years were significantly lower in the frail group than in the non-frail group (p < 0.01). Cox proportional hazards regression analyses revealed the CFS score as associated with the occurrence of a composite outcome, independently of age (hazard ratio 1.34, 95% confidence interval 1.04–1.72). Frailty assessment based on clinical judgment using CFS might predict adverse outcomes in dialysis-initiated patients.https://doi.org/10.1038/s41598-022-22483-8 |
| spellingShingle | Rikako Oki Yoshifumi Hamasaki Shiho Tsuji Kana Suzuki Sayaka Tsuneishi Mikie Imafuku Yohei Komaru Yoshihisa Miyamoto Ryo Matsuura Kent Doi Masaomi Nangaku Clinical frailty assessment might be associated with mortality in incident dialysis patients Scientific Reports |
| title | Clinical frailty assessment might be associated with mortality in incident dialysis patients |
| title_full | Clinical frailty assessment might be associated with mortality in incident dialysis patients |
| title_fullStr | Clinical frailty assessment might be associated with mortality in incident dialysis patients |
| title_full_unstemmed | Clinical frailty assessment might be associated with mortality in incident dialysis patients |
| title_short | Clinical frailty assessment might be associated with mortality in incident dialysis patients |
| title_sort | clinical frailty assessment might be associated with mortality in incident dialysis patients |
| url | https://doi.org/10.1038/s41598-022-22483-8 |
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