DETECTION OF FLUOROQUINOLONE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS ISOLATE CAUSED BY MUTATION IN THE GYRA GENE
Drug-resistant tuberculosis is a public health concern. TB that is drug-resistant to rifampin and isoniazid is known as MDR-TB, whereas XDR-TB is MDR-TB that is also resistant to second-line medicines, such as fluoroquinolones (levofloxacin, ofloxacin, and moxifloxacin). rifampin-resistant tuberculo...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Indonesian |
| Published: |
Universitas Sriwijaya
2022-05-01
|
| Series: | Jurnal Kedokteran dan Kesehatan |
| Online Access: | https://ejournal.unsri.ac.id/index.php/jkk/article/view/16554 |
| _version_ | 1818553709726007296 |
|---|---|
| author | Citra Wulandari Ziske Maritska |
| author_facet | Citra Wulandari Ziske Maritska |
| author_sort | Citra Wulandari |
| collection | DOAJ |
| description | Drug-resistant tuberculosis is a public health concern. TB that is drug-resistant to rifampin and isoniazid is known as MDR-TB, whereas XDR-TB is MDR-TB that is also resistant to second-line medicines, such as fluoroquinolones (levofloxacin, ofloxacin, and moxifloxacin). rifampin-resistant tuberculosis (RR-TB), of which 78 percent had multidrug-resistant tuberculosis (MDR-TB) (MDR-TB). Fluoroquinolones are a class of broad-spectrum antimicrobials that have become increasingly popular in recent years. Fluoroquinolones have activity against Mycobacterium tuberculosis both in vitro and in vivo. Fluoroquinolones might cause resistance if they are used inappropriately or excessively. According to several investigations, the majority of fluoroquinolone-resistant M. tuberculosis isolates (approximately 50-90 percent) had mutations in the gyrA gene QRDR Quinolone Resistance Determination Region. However, the genetic involvement of various gyrA gene mutations in resistant Mycobacterium TB isolates against fluoroquinolone resistance remains an unknown gyrA gene mutation pattern in resistant Mycobacterium tuberculosis isolates. In the previous investigation, mutations in the gyrA gene were discovered at codons 90 and 94. |
| first_indexed | 2024-12-12T09:29:23Z |
| format | Article |
| id | doaj.art-b18ac2a45b4048c2a3c39cc817022047 |
| institution | Directory Open Access Journal |
| issn | 2406-7431 2614-0411 |
| language | Indonesian |
| last_indexed | 2024-12-12T09:29:23Z |
| publishDate | 2022-05-01 |
| publisher | Universitas Sriwijaya |
| record_format | Article |
| series | Jurnal Kedokteran dan Kesehatan |
| spelling | doaj.art-b18ac2a45b4048c2a3c39cc8170220472022-12-22T00:28:54ZindUniversitas SriwijayaJurnal Kedokteran dan Kesehatan2406-74312614-04112022-05-019111712210.32539/JKK.V9I1.165546185DETECTION OF FLUOROQUINOLONE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS ISOLATE CAUSED BY MUTATION IN THE GYRA GENECitra Wulandari0Ziske MaritskaSriwijaya UniversityDrug-resistant tuberculosis is a public health concern. TB that is drug-resistant to rifampin and isoniazid is known as MDR-TB, whereas XDR-TB is MDR-TB that is also resistant to second-line medicines, such as fluoroquinolones (levofloxacin, ofloxacin, and moxifloxacin). rifampin-resistant tuberculosis (RR-TB), of which 78 percent had multidrug-resistant tuberculosis (MDR-TB) (MDR-TB). Fluoroquinolones are a class of broad-spectrum antimicrobials that have become increasingly popular in recent years. Fluoroquinolones have activity against Mycobacterium tuberculosis both in vitro and in vivo. Fluoroquinolones might cause resistance if they are used inappropriately or excessively. According to several investigations, the majority of fluoroquinolone-resistant M. tuberculosis isolates (approximately 50-90 percent) had mutations in the gyrA gene QRDR Quinolone Resistance Determination Region. However, the genetic involvement of various gyrA gene mutations in resistant Mycobacterium TB isolates against fluoroquinolone resistance remains an unknown gyrA gene mutation pattern in resistant Mycobacterium tuberculosis isolates. In the previous investigation, mutations in the gyrA gene were discovered at codons 90 and 94.https://ejournal.unsri.ac.id/index.php/jkk/article/view/16554 |
| spellingShingle | Citra Wulandari Ziske Maritska DETECTION OF FLUOROQUINOLONE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS ISOLATE CAUSED BY MUTATION IN THE GYRA GENE Jurnal Kedokteran dan Kesehatan |
| title | DETECTION OF FLUOROQUINOLONE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS ISOLATE CAUSED BY MUTATION IN THE GYRA GENE |
| title_full | DETECTION OF FLUOROQUINOLONE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS ISOLATE CAUSED BY MUTATION IN THE GYRA GENE |
| title_fullStr | DETECTION OF FLUOROQUINOLONE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS ISOLATE CAUSED BY MUTATION IN THE GYRA GENE |
| title_full_unstemmed | DETECTION OF FLUOROQUINOLONE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS ISOLATE CAUSED BY MUTATION IN THE GYRA GENE |
| title_short | DETECTION OF FLUOROQUINOLONE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS ISOLATE CAUSED BY MUTATION IN THE GYRA GENE |
| title_sort | detection of fluoroquinolone resistance in mycobacterium tuberculosis isolate caused by mutation in the gyra gene |
| url | https://ejournal.unsri.ac.id/index.php/jkk/article/view/16554 |
| work_keys_str_mv | AT citrawulandari detectionoffluoroquinoloneresistanceinmycobacteriumtuberculosisisolatecausedbymutationinthegyragene AT ziskemaritska detectionoffluoroquinoloneresistanceinmycobacteriumtuberculosisisolatecausedbymutationinthegyragene |