Cross-sectional analyses of metabolites across biological samples mediating dietary acid load and chronic kidney disease
Summary: Chronic kidney disease (CKD) is a major public health burden, with dietary acid load (DAL) and gut microbiota playing crucial roles. As DAL can affect the host metabolome, potentially via the gut microbiota, we cross-sectionally investigated the interplay between DAL, host metabolome, gut m...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224003535 |
| _version_ | 1797294287574007808 |
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| author | Ilias Attaye Beverley Beynon-Cobb Panayiotis Louca Ana Nogal Alessia Visconti Francesca Tettamanzi Kari Wong Gregory Michellotti Tim D. Spector Mario Falchi Jordana T. Bell Cristina Menni |
| author_facet | Ilias Attaye Beverley Beynon-Cobb Panayiotis Louca Ana Nogal Alessia Visconti Francesca Tettamanzi Kari Wong Gregory Michellotti Tim D. Spector Mario Falchi Jordana T. Bell Cristina Menni |
| author_sort | Ilias Attaye |
| collection | DOAJ |
| description | Summary: Chronic kidney disease (CKD) is a major public health burden, with dietary acid load (DAL) and gut microbiota playing crucial roles. As DAL can affect the host metabolome, potentially via the gut microbiota, we cross-sectionally investigated the interplay between DAL, host metabolome, gut microbiota, and early-stage CKD (TwinsUK, n = 1,453). DAL was positively associated with CKD stage G1-G2 (Beta (95% confidence interval) = 0.34 (0.007; 0.7), p = 0.046). After adjusting for covariates and multiple testing, we identified 15 serum, 14 urine, 8 stool, and 7 saliva metabolites, primarily lipids and amino acids, associated with both DAL and CKD progression. Of these, 8 serum, 2 urine, and one stool metabolites were found to mediate the DAL-CKD association. Furthermore, the stool metabolite 5-methylhexanoate (i7:0) correlated with 26 gut microbial species. Our findings emphasize the gut microbiota’s therapeutic potential in countering DAL’s impact on CKD through the host metabolome. Interventional and longitudinal studies are needed to establish causality. |
| first_indexed | 2024-03-07T21:28:05Z |
| format | Article |
| id | doaj.art-b18bc96c8c394ce9880b42bf971f8fd4 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-07T21:28:05Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-b18bc96c8c394ce9880b42bf971f8fd42024-02-27T04:20:07ZengElsevieriScience2589-00422024-03-01273109132Cross-sectional analyses of metabolites across biological samples mediating dietary acid load and chronic kidney diseaseIlias Attaye0Beverley Beynon-Cobb1Panayiotis Louca2Ana Nogal3Alessia Visconti4Francesca Tettamanzi5Kari Wong6Gregory Michellotti7Tim D. Spector8Mario Falchi9Jordana T. Bell10Cristina Menni11Department of Twin Research, King’s College London, St Thomas' Hospital Campus, London SE1 7EH, UK; Amsterdam Cardiovascular Sciences, Diabetes & Metabolism, Amsterdam, the Netherlands; Corresponding authorDepartment of Twin Research, King’s College London, St Thomas' Hospital Campus, London SE1 7EH, UK; Department of Nutrition & Dietetics, University Hospitals Coventry & Warwickshire NHS Trust, Coventry CV2 2DX, UKDepartment of Twin Research, King’s College London, St Thomas' Hospital Campus, London SE1 7EH, UKDepartment of Twin Research, King’s College London, St Thomas' Hospital Campus, London SE1 7EH, UKDepartment of Twin Research, King’s College London, St Thomas' Hospital Campus, London SE1 7EH, UKDepartment of Twin Research, King’s College London, St Thomas' Hospital Campus, London SE1 7EH, UKMetabolon, Research Triangle Park, Morrisville, NC 27560, USAMetabolon, Research Triangle Park, Morrisville, NC 27560, USADepartment of Twin Research, King’s College London, St Thomas' Hospital Campus, London SE1 7EH, UKDepartment of Twin Research, King’s College London, St Thomas' Hospital Campus, London SE1 7EH, UKDepartment of Twin Research, King’s College London, St Thomas' Hospital Campus, London SE1 7EH, UKDepartment of Twin Research, King’s College London, St Thomas' Hospital Campus, London SE1 7EH, UK; Corresponding authorSummary: Chronic kidney disease (CKD) is a major public health burden, with dietary acid load (DAL) and gut microbiota playing crucial roles. As DAL can affect the host metabolome, potentially via the gut microbiota, we cross-sectionally investigated the interplay between DAL, host metabolome, gut microbiota, and early-stage CKD (TwinsUK, n = 1,453). DAL was positively associated with CKD stage G1-G2 (Beta (95% confidence interval) = 0.34 (0.007; 0.7), p = 0.046). After adjusting for covariates and multiple testing, we identified 15 serum, 14 urine, 8 stool, and 7 saliva metabolites, primarily lipids and amino acids, associated with both DAL and CKD progression. Of these, 8 serum, 2 urine, and one stool metabolites were found to mediate the DAL-CKD association. Furthermore, the stool metabolite 5-methylhexanoate (i7:0) correlated with 26 gut microbial species. Our findings emphasize the gut microbiota’s therapeutic potential in countering DAL’s impact on CKD through the host metabolome. Interventional and longitudinal studies are needed to establish causality.http://www.sciencedirect.com/science/article/pii/S2589004224003535Health sciencesMedicineMedical specialtyInternal medicineNephrologyNatural sciences |
| spellingShingle | Ilias Attaye Beverley Beynon-Cobb Panayiotis Louca Ana Nogal Alessia Visconti Francesca Tettamanzi Kari Wong Gregory Michellotti Tim D. Spector Mario Falchi Jordana T. Bell Cristina Menni Cross-sectional analyses of metabolites across biological samples mediating dietary acid load and chronic kidney disease iScience Health sciences Medicine Medical specialty Internal medicine Nephrology Natural sciences |
| title | Cross-sectional analyses of metabolites across biological samples mediating dietary acid load and chronic kidney disease |
| title_full | Cross-sectional analyses of metabolites across biological samples mediating dietary acid load and chronic kidney disease |
| title_fullStr | Cross-sectional analyses of metabolites across biological samples mediating dietary acid load and chronic kidney disease |
| title_full_unstemmed | Cross-sectional analyses of metabolites across biological samples mediating dietary acid load and chronic kidney disease |
| title_short | Cross-sectional analyses of metabolites across biological samples mediating dietary acid load and chronic kidney disease |
| title_sort | cross sectional analyses of metabolites across biological samples mediating dietary acid load and chronic kidney disease |
| topic | Health sciences Medicine Medical specialty Internal medicine Nephrology Natural sciences |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224003535 |
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