Recent Advances in Two-Dimensional Transition Metal Dichalcogenide Nanocomposites Biosensors for Virus Detection before and during COVID-19 Outbreak
The deadly Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outbreak has become one of the most challenging pandemics in the last century. Clinical diagnosis reports a high infection rate within a large population and a rapid mutation rate upon every individual infection. The polymerase...
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| Format: | Article |
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MDPI AG
2021-07-01
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| Series: | Journal of Composites Science |
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| Online Access: | https://www.mdpi.com/2504-477X/5/7/190 |
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| author | Ching Ying Katherine Lam Qin Zhang Bohan Yin Yingying Huang Hui Wang Mo Yang Siu Hong Dexter Wong |
| author_facet | Ching Ying Katherine Lam Qin Zhang Bohan Yin Yingying Huang Hui Wang Mo Yang Siu Hong Dexter Wong |
| author_sort | Ching Ying Katherine Lam |
| collection | DOAJ |
| description | The deadly Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outbreak has become one of the most challenging pandemics in the last century. Clinical diagnosis reports a high infection rate within a large population and a rapid mutation rate upon every individual infection. The polymerase chain reaction has been a powerful and gold standard molecular diagnostic technique over the past few decades and hence a promising tool to detect the SARS-CoV-2 nucleic acid sequences. However, it can be costly and involved in complicated processes with a high demand for on-site tests. This pandemic emphasizes the critical need for designing cost-effective and fast diagnosis strategies to prevent a potential viral source by ultrasensitive and selective biosensors. Two-dimensional (2D) transition metal dichalcogenide (TMD) nanocomposites have been developed with unique physical and chemical properties crucial for building up nucleic acid and protein biosensors. In this review, we cover various types of 2D TMD biosensors available for virus detection via the mechanisms of photoluminescence/optical, field-effect transistor, surface plasmon resonance, and electrochemical signals. We summarize the current state-of-the-art applications of 2D TMD nanocomposite systems for sensing proteins/nucleic acid from different types of lethal viruses. Finally, we identify and discuss the advantages and limitations of TMD-based nanocomposites biosensors for viral recognition. |
| first_indexed | 2024-03-10T09:35:37Z |
| format | Article |
| id | doaj.art-b18cac0aa62e4150a8bff2ee3789eaeb |
| institution | Directory Open Access Journal |
| issn | 2504-477X |
| language | English |
| last_indexed | 2024-03-10T09:35:37Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Composites Science |
| spelling | doaj.art-b18cac0aa62e4150a8bff2ee3789eaeb2023-11-22T04:08:29ZengMDPI AGJournal of Composites Science2504-477X2021-07-015719010.3390/jcs5070190Recent Advances in Two-Dimensional Transition Metal Dichalcogenide Nanocomposites Biosensors for Virus Detection before and during COVID-19 OutbreakChing Ying Katherine Lam0Qin Zhang1Bohan Yin2Yingying Huang3Hui Wang4Mo Yang5Siu Hong Dexter Wong6Department of Biomedical Engineering, Hong Kong Polytechnic University, Hong Kong 999077, ChinaDepartment of Biomedical Engineering, Hong Kong Polytechnic University, Hong Kong 999077, ChinaDepartment of Biomedical Engineering, Hong Kong Polytechnic University, Hong Kong 999077, ChinaDepartment of Biomedical Engineering, Hong Kong Polytechnic University, Hong Kong 999077, ChinaFishery Resource and Environment Research Center, Chinese Academy of Fishery Sciences, Beijing 100141, ChinaDepartment of Biomedical Engineering, Hong Kong Polytechnic University, Hong Kong 999077, ChinaDepartment of Biomedical Engineering, Hong Kong Polytechnic University, Hong Kong 999077, ChinaThe deadly Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outbreak has become one of the most challenging pandemics in the last century. Clinical diagnosis reports a high infection rate within a large population and a rapid mutation rate upon every individual infection. The polymerase chain reaction has been a powerful and gold standard molecular diagnostic technique over the past few decades and hence a promising tool to detect the SARS-CoV-2 nucleic acid sequences. However, it can be costly and involved in complicated processes with a high demand for on-site tests. This pandemic emphasizes the critical need for designing cost-effective and fast diagnosis strategies to prevent a potential viral source by ultrasensitive and selective biosensors. Two-dimensional (2D) transition metal dichalcogenide (TMD) nanocomposites have been developed with unique physical and chemical properties crucial for building up nucleic acid and protein biosensors. In this review, we cover various types of 2D TMD biosensors available for virus detection via the mechanisms of photoluminescence/optical, field-effect transistor, surface plasmon resonance, and electrochemical signals. We summarize the current state-of-the-art applications of 2D TMD nanocomposite systems for sensing proteins/nucleic acid from different types of lethal viruses. Finally, we identify and discuss the advantages and limitations of TMD-based nanocomposites biosensors for viral recognition.https://www.mdpi.com/2504-477X/5/7/190transition metal dichalcogenidenanocompositesSARS-CoV-2biosensors |
| spellingShingle | Ching Ying Katherine Lam Qin Zhang Bohan Yin Yingying Huang Hui Wang Mo Yang Siu Hong Dexter Wong Recent Advances in Two-Dimensional Transition Metal Dichalcogenide Nanocomposites Biosensors for Virus Detection before and during COVID-19 Outbreak Journal of Composites Science transition metal dichalcogenide nanocomposites SARS-CoV-2 biosensors |
| title | Recent Advances in Two-Dimensional Transition Metal Dichalcogenide Nanocomposites Biosensors for Virus Detection before and during COVID-19 Outbreak |
| title_full | Recent Advances in Two-Dimensional Transition Metal Dichalcogenide Nanocomposites Biosensors for Virus Detection before and during COVID-19 Outbreak |
| title_fullStr | Recent Advances in Two-Dimensional Transition Metal Dichalcogenide Nanocomposites Biosensors for Virus Detection before and during COVID-19 Outbreak |
| title_full_unstemmed | Recent Advances in Two-Dimensional Transition Metal Dichalcogenide Nanocomposites Biosensors for Virus Detection before and during COVID-19 Outbreak |
| title_short | Recent Advances in Two-Dimensional Transition Metal Dichalcogenide Nanocomposites Biosensors for Virus Detection before and during COVID-19 Outbreak |
| title_sort | recent advances in two dimensional transition metal dichalcogenide nanocomposites biosensors for virus detection before and during covid 19 outbreak |
| topic | transition metal dichalcogenide nanocomposites SARS-CoV-2 biosensors |
| url | https://www.mdpi.com/2504-477X/5/7/190 |
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