Enhancement in Oral Absorption of Ceftriaxone by Highly Functionalized Magnetic Iron Oxide Nanoparticles
The present study aims at the development, characterization, biocompatibility investigation and oral bioavailability evaluation of ceftriaxone (CFT)-loaded N′-methacryloylisonicotinohydrazide (MIH)-functionalized magnetic nanoparticles (CFT-MIH-MNPs). Atomic force microscopy (AFM) and dynamic light...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/12/6/492 |
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| author | Muhammad Kawish Abdelbary Elhissi Tooba Jabri Kanwal Muhammad Iqbal Hina Zahid Muhammad Raza Shah |
| author_facet | Muhammad Kawish Abdelbary Elhissi Tooba Jabri Kanwal Muhammad Iqbal Hina Zahid Muhammad Raza Shah |
| author_sort | Muhammad Kawish |
| collection | DOAJ |
| description | The present study aims at the development, characterization, biocompatibility investigation and oral bioavailability evaluation of ceftriaxone (CFT)-loaded N′-methacryloylisonicotinohydrazide (MIH)-functionalized magnetic nanoparticles (CFT-MIH-MNPs). Atomic force microscopy (AFM) and dynamic light scattering (DLS) showed that the developed CFT loaded MIH-MNPs are spherical, with a measured hydrodynamic size of 184.0 ± 2.7 nm and negative zeta potential values (–20.2 ± 0.4 mV). Fourier transformed infrared spectroscopic (FTIR) analysis revealed interactions between the nanocarrier and the drug. Nanoparticles showed high drug entrapment efficiency (EE) of 79.4% ±1.5%, and the drug was released gradually in vitro and showed prolonged in vitro stability using simulated gastrointestinal tract (GIT) fluids. The formulations were found to be highly biocompatible (up to 100 µg/mL) and hemocompatible (up to 1.0 mg/mL). Using an albino rabbit model, the formulation showed a significant enhancement in drug plasma concentration up to 14.4 ± 1.8 µg/mL in comparison with its control (2.0 ± 0.6 µg/mL). Overall, the developed CFT-MIH-MNPs formulation was promising for provision of high drug entrapment, gradual drug release and suitability for enhancing the oral delivery of CFT. |
| first_indexed | 2024-03-10T19:31:45Z |
| format | Article |
| id | doaj.art-b18ded4917be40f7977a631d56d97e32 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T19:31:45Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-b18ded4917be40f7977a631d56d97e322023-11-20T02:04:18ZengMDPI AGPharmaceutics1999-49232020-05-0112649210.3390/pharmaceutics12060492Enhancement in Oral Absorption of Ceftriaxone by Highly Functionalized Magnetic Iron Oxide NanoparticlesMuhammad Kawish0Abdelbary Elhissi1Tooba Jabri2Kanwal Muhammad Iqbal3Hina Zahid4Muhammad Raza Shah5International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi 75270, PakistanCollege of Pharmacy, QU Health, and Office of VP for Research and Graduate Studies, Qatar University, Doha 2713, QatarInternational Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi 75270, PakistanInternational Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi 75270, PakistanFaculty of Pharmaceutical Sciences Dow University of Health Sciences Karachi, Karachi 74200, PakistanInternational Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi 75270, PakistanThe present study aims at the development, characterization, biocompatibility investigation and oral bioavailability evaluation of ceftriaxone (CFT)-loaded N′-methacryloylisonicotinohydrazide (MIH)-functionalized magnetic nanoparticles (CFT-MIH-MNPs). Atomic force microscopy (AFM) and dynamic light scattering (DLS) showed that the developed CFT loaded MIH-MNPs are spherical, with a measured hydrodynamic size of 184.0 ± 2.7 nm and negative zeta potential values (–20.2 ± 0.4 mV). Fourier transformed infrared spectroscopic (FTIR) analysis revealed interactions between the nanocarrier and the drug. Nanoparticles showed high drug entrapment efficiency (EE) of 79.4% ±1.5%, and the drug was released gradually in vitro and showed prolonged in vitro stability using simulated gastrointestinal tract (GIT) fluids. The formulations were found to be highly biocompatible (up to 100 µg/mL) and hemocompatible (up to 1.0 mg/mL). Using an albino rabbit model, the formulation showed a significant enhancement in drug plasma concentration up to 14.4 ± 1.8 µg/mL in comparison with its control (2.0 ± 0.6 µg/mL). Overall, the developed CFT-MIH-MNPs formulation was promising for provision of high drug entrapment, gradual drug release and suitability for enhancing the oral delivery of CFT.https://www.mdpi.com/1999-4923/12/6/492iron oxide nanoparticlessurface functionalizationbiocompatibilityceftriaxoneoral delivery |
| spellingShingle | Muhammad Kawish Abdelbary Elhissi Tooba Jabri Kanwal Muhammad Iqbal Hina Zahid Muhammad Raza Shah Enhancement in Oral Absorption of Ceftriaxone by Highly Functionalized Magnetic Iron Oxide Nanoparticles Pharmaceutics iron oxide nanoparticles surface functionalization biocompatibility ceftriaxone oral delivery |
| title | Enhancement in Oral Absorption of Ceftriaxone by Highly Functionalized Magnetic Iron Oxide Nanoparticles |
| title_full | Enhancement in Oral Absorption of Ceftriaxone by Highly Functionalized Magnetic Iron Oxide Nanoparticles |
| title_fullStr | Enhancement in Oral Absorption of Ceftriaxone by Highly Functionalized Magnetic Iron Oxide Nanoparticles |
| title_full_unstemmed | Enhancement in Oral Absorption of Ceftriaxone by Highly Functionalized Magnetic Iron Oxide Nanoparticles |
| title_short | Enhancement in Oral Absorption of Ceftriaxone by Highly Functionalized Magnetic Iron Oxide Nanoparticles |
| title_sort | enhancement in oral absorption of ceftriaxone by highly functionalized magnetic iron oxide nanoparticles |
| topic | iron oxide nanoparticles surface functionalization biocompatibility ceftriaxone oral delivery |
| url | https://www.mdpi.com/1999-4923/12/6/492 |
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