Association of glycemic status and segmental left ventricular wall thickness in subjects without prior cardiovascular disease: a cross-sectional study
Abstract Background Left ventricular (LV) hypertrophy and changes in LV geometry are associated with increased cardiovascular mortality. Subjects with type 2 diabetes have an increased risk of such alterations in cardiac morphology. We sought to assess the association of glycemic status and LV wall...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-08-01
|
| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12872-018-0900-7 |
| _version_ | 1818189201222402048 |
|---|---|
| author | Susanne Rospleszcz Anina Schafnitzel Wolfgang Koenig Roberto Lorbeer Sigrid Auweter Cornelia Huth Wolfgang Rathmann Margit Heier Birgit Linkohr Christa Meisinger Holger Hetterich Fabian Bamberg Annette Peters |
| author_facet | Susanne Rospleszcz Anina Schafnitzel Wolfgang Koenig Roberto Lorbeer Sigrid Auweter Cornelia Huth Wolfgang Rathmann Margit Heier Birgit Linkohr Christa Meisinger Holger Hetterich Fabian Bamberg Annette Peters |
| author_sort | Susanne Rospleszcz |
| collection | DOAJ |
| description | Abstract Background Left ventricular (LV) hypertrophy and changes in LV geometry are associated with increased cardiovascular mortality. Subjects with type 2 diabetes have an increased risk of such alterations in cardiac morphology. We sought to assess the association of glycemic status and LV wall thickness measured by cardiac magnetic resonance (CMR), and potential interactions of hypertension and diabetes. Methods CMR was performed on 359 participants from a cross-sectional study nested in a population-based cohort (KORA FF4) free of overt cardiovascular disease. Participants were classified according to their glycemic status as either control (normal glucose metabolism), prediabetes or type 2 diabetes. Segmentation of the left ventricle was defined according to the American Heart Association (AHA) 16-segment model. Measurements of wall thickness were obtained at end-diastole and analyzed by linear regression models adjusted for traditional cardiovascular risk factors. Results LV wall thickness gradually increased from normoglycemic controls to subjects with prediabetes and subjects with diabetes (8.8 ± 1.4 vs 9.9 ± 1.4 vs 10.5 ± 1.6 mm, respectively). The association was independent of hypertension and traditional cardiovascular risk factors (β-coefficient: 0.44 mm for prediabetes and 0.70 mm for diabetes, p-values compared to controls: p = 0.007 and p = 0.004, respectively). Whereas the association of glycemic status was strongest for the mid-cavity segments, the association of hypertension was strongest for the basal segments. Conclusion Abnormal glucose metabolism, including pre-diabetes, is associated with increased LV wall thickness independent of hypertension. |
| first_indexed | 2024-12-11T23:39:03Z |
| format | Article |
| id | doaj.art-b18ebdcb8a9b4f94bacaab669d0f2795 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-11T23:39:03Z |
| publishDate | 2018-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-b18ebdcb8a9b4f94bacaab669d0f27952022-12-22T00:45:47ZengBMCBMC Cardiovascular Disorders1471-22612018-08-0118111010.1186/s12872-018-0900-7Association of glycemic status and segmental left ventricular wall thickness in subjects without prior cardiovascular disease: a cross-sectional studySusanne Rospleszcz0Anina Schafnitzel1Wolfgang Koenig2Roberto Lorbeer3Sigrid Auweter4Cornelia Huth5Wolfgang Rathmann6Margit Heier7Birgit Linkohr8Christa Meisinger9Holger Hetterich10Fabian Bamberg11Annette Peters12Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental HealthDepartment of Radiology, Ludwig-Maximilians-University HospitalDepartment of Internal Medicine II – Cardiology, University of Ulm Medical CenterDepartment of Radiology, Ludwig-Maximilians-University HospitalDepartment of Radiology, Ludwig-Maximilians-University HospitalInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental HealthGerman Center for Diabetes Research (DZD)Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental HealthInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental HealthInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental HealthDepartment of Radiology, Ludwig-Maximilians-University HospitalDepartment of Radiology, Ludwig-Maximilians-University HospitalInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental HealthAbstract Background Left ventricular (LV) hypertrophy and changes in LV geometry are associated with increased cardiovascular mortality. Subjects with type 2 diabetes have an increased risk of such alterations in cardiac morphology. We sought to assess the association of glycemic status and LV wall thickness measured by cardiac magnetic resonance (CMR), and potential interactions of hypertension and diabetes. Methods CMR was performed on 359 participants from a cross-sectional study nested in a population-based cohort (KORA FF4) free of overt cardiovascular disease. Participants were classified according to their glycemic status as either control (normal glucose metabolism), prediabetes or type 2 diabetes. Segmentation of the left ventricle was defined according to the American Heart Association (AHA) 16-segment model. Measurements of wall thickness were obtained at end-diastole and analyzed by linear regression models adjusted for traditional cardiovascular risk factors. Results LV wall thickness gradually increased from normoglycemic controls to subjects with prediabetes and subjects with diabetes (8.8 ± 1.4 vs 9.9 ± 1.4 vs 10.5 ± 1.6 mm, respectively). The association was independent of hypertension and traditional cardiovascular risk factors (β-coefficient: 0.44 mm for prediabetes and 0.70 mm for diabetes, p-values compared to controls: p = 0.007 and p = 0.004, respectively). Whereas the association of glycemic status was strongest for the mid-cavity segments, the association of hypertension was strongest for the basal segments. Conclusion Abnormal glucose metabolism, including pre-diabetes, is associated with increased LV wall thickness independent of hypertension.http://link.springer.com/article/10.1186/s12872-018-0900-7Cardiac magnetic resonance imagingPrediabetesDiabetesLeft ventricular wall thickness16-segment model |
| spellingShingle | Susanne Rospleszcz Anina Schafnitzel Wolfgang Koenig Roberto Lorbeer Sigrid Auweter Cornelia Huth Wolfgang Rathmann Margit Heier Birgit Linkohr Christa Meisinger Holger Hetterich Fabian Bamberg Annette Peters Association of glycemic status and segmental left ventricular wall thickness in subjects without prior cardiovascular disease: a cross-sectional study BMC Cardiovascular Disorders Cardiac magnetic resonance imaging Prediabetes Diabetes Left ventricular wall thickness 16-segment model |
| title | Association of glycemic status and segmental left ventricular wall thickness in subjects without prior cardiovascular disease: a cross-sectional study |
| title_full | Association of glycemic status and segmental left ventricular wall thickness in subjects without prior cardiovascular disease: a cross-sectional study |
| title_fullStr | Association of glycemic status and segmental left ventricular wall thickness in subjects without prior cardiovascular disease: a cross-sectional study |
| title_full_unstemmed | Association of glycemic status and segmental left ventricular wall thickness in subjects without prior cardiovascular disease: a cross-sectional study |
| title_short | Association of glycemic status and segmental left ventricular wall thickness in subjects without prior cardiovascular disease: a cross-sectional study |
| title_sort | association of glycemic status and segmental left ventricular wall thickness in subjects without prior cardiovascular disease a cross sectional study |
| topic | Cardiac magnetic resonance imaging Prediabetes Diabetes Left ventricular wall thickness 16-segment model |
| url | http://link.springer.com/article/10.1186/s12872-018-0900-7 |
| work_keys_str_mv | AT susannerospleszcz associationofglycemicstatusandsegmentalleftventricularwallthicknessinsubjectswithoutpriorcardiovasculardiseaseacrosssectionalstudy AT aninaschafnitzel associationofglycemicstatusandsegmentalleftventricularwallthicknessinsubjectswithoutpriorcardiovasculardiseaseacrosssectionalstudy AT wolfgangkoenig associationofglycemicstatusandsegmentalleftventricularwallthicknessinsubjectswithoutpriorcardiovasculardiseaseacrosssectionalstudy AT robertolorbeer associationofglycemicstatusandsegmentalleftventricularwallthicknessinsubjectswithoutpriorcardiovasculardiseaseacrosssectionalstudy AT sigridauweter associationofglycemicstatusandsegmentalleftventricularwallthicknessinsubjectswithoutpriorcardiovasculardiseaseacrosssectionalstudy AT corneliahuth associationofglycemicstatusandsegmentalleftventricularwallthicknessinsubjectswithoutpriorcardiovasculardiseaseacrosssectionalstudy AT wolfgangrathmann associationofglycemicstatusandsegmentalleftventricularwallthicknessinsubjectswithoutpriorcardiovasculardiseaseacrosssectionalstudy AT margitheier associationofglycemicstatusandsegmentalleftventricularwallthicknessinsubjectswithoutpriorcardiovasculardiseaseacrosssectionalstudy AT birgitlinkohr associationofglycemicstatusandsegmentalleftventricularwallthicknessinsubjectswithoutpriorcardiovasculardiseaseacrosssectionalstudy AT christameisinger associationofglycemicstatusandsegmentalleftventricularwallthicknessinsubjectswithoutpriorcardiovasculardiseaseacrosssectionalstudy AT holgerhetterich associationofglycemicstatusandsegmentalleftventricularwallthicknessinsubjectswithoutpriorcardiovasculardiseaseacrosssectionalstudy AT fabianbamberg associationofglycemicstatusandsegmentalleftventricularwallthicknessinsubjectswithoutpriorcardiovasculardiseaseacrosssectionalstudy AT annettepeters associationofglycemicstatusandsegmentalleftventricularwallthicknessinsubjectswithoutpriorcardiovasculardiseaseacrosssectionalstudy |