Camera-based optical palpation
Abstract Optical elastography is undergoing extensive development as an imaging tool to map mechanical contrast in tissue. Here, we present a new platform for optical elastography by generating sub-millimetre-scale mechanical contrast from a simple digital camera. This cost-effective, compact and ea...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-72603-5 |
| _version_ | 1830199744311328768 |
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| author | Rowan W. Sanderson Qi Fang Andrea Curatolo Wayne Adams Devina D. Lakhiani Hina M. Ismail Ken Y. Foo Benjamin F. Dessauvagie Bruce Latham Chris Yeomans Christobel M. Saunders Brendan F. Kennedy |
| author_facet | Rowan W. Sanderson Qi Fang Andrea Curatolo Wayne Adams Devina D. Lakhiani Hina M. Ismail Ken Y. Foo Benjamin F. Dessauvagie Bruce Latham Chris Yeomans Christobel M. Saunders Brendan F. Kennedy |
| author_sort | Rowan W. Sanderson |
| collection | DOAJ |
| description | Abstract Optical elastography is undergoing extensive development as an imaging tool to map mechanical contrast in tissue. Here, we present a new platform for optical elastography by generating sub-millimetre-scale mechanical contrast from a simple digital camera. This cost-effective, compact and easy-to-implement approach opens the possibility to greatly expand applications of optical elastography both within and beyond the field of medical imaging. Camera-based optical palpation (CBOP) utilises a digital camera to acquire photographs that quantify the light intensity transmitted through a silicone layer comprising a dense distribution of micro-pores (diameter, 30–100 µm). As the transmission of light through the micro-pores increases with compression, we deduce strain in the layer directly from intensity in the digital photograph. By pre-characterising the relationship between stress and strain of the layer, the measured strain map can be converted to an optical palpogram, a map of stress that visualises mechanical contrast in the sample. We demonstrate a spatial resolution as high as 290 µm in CBOP, comparable to that achieved using an optical coherence tomography-based implementation of optical palpation. In this paper, we describe the fabrication of the micro-porous layer and present experimental results from structured phantoms containing stiff inclusions as small as 0.5 × 0.5 × 1 mm. In each case, we demonstrate high contrast between the inclusion and the base material and validate both the contrast and spatial resolution achieved using finite element modelling. By performing CBOP on freshly excised human breast tissue, we demonstrate the capability to delineate tumour from surrounding benign tissue. |
| first_indexed | 2024-12-18T02:19:07Z |
| format | Article |
| id | doaj.art-b190b40a0c78454c90de791f8fbc598d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-18T02:19:07Z |
| publishDate | 2020-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b190b40a0c78454c90de791f8fbc598d2022-12-21T21:24:18ZengNature PortfolioScientific Reports2045-23222020-09-0110111310.1038/s41598-020-72603-5Camera-based optical palpationRowan W. Sanderson0Qi Fang1Andrea Curatolo2Wayne Adams3Devina D. Lakhiani4Hina M. Ismail5Ken Y. Foo6Benjamin F. Dessauvagie7Bruce Latham8Chris Yeomans9Christobel M. Saunders10Brendan F. Kennedy11BRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands and Centre for Medical Research, The University of Western AustraliaBRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands and Centre for Medical Research, The University of Western AustraliaDepartment of Electrical, Electronic & Computer Engineering, School of Engineering, The University of Western AustraliaBRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands and Centre for Medical Research, The University of Western AustraliaBRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands and Centre for Medical Research, The University of Western AustraliaBRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands and Centre for Medical Research, The University of Western AustraliaBRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands and Centre for Medical Research, The University of Western AustraliaPathWest, Fiona Stanley HospitalPathWest, Fiona Stanley HospitalPathWest, Fiona Stanley HospitalDivision of Surgery, Medical School, The University of Western AustraliaBRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands and Centre for Medical Research, The University of Western AustraliaAbstract Optical elastography is undergoing extensive development as an imaging tool to map mechanical contrast in tissue. Here, we present a new platform for optical elastography by generating sub-millimetre-scale mechanical contrast from a simple digital camera. This cost-effective, compact and easy-to-implement approach opens the possibility to greatly expand applications of optical elastography both within and beyond the field of medical imaging. Camera-based optical palpation (CBOP) utilises a digital camera to acquire photographs that quantify the light intensity transmitted through a silicone layer comprising a dense distribution of micro-pores (diameter, 30–100 µm). As the transmission of light through the micro-pores increases with compression, we deduce strain in the layer directly from intensity in the digital photograph. By pre-characterising the relationship between stress and strain of the layer, the measured strain map can be converted to an optical palpogram, a map of stress that visualises mechanical contrast in the sample. We demonstrate a spatial resolution as high as 290 µm in CBOP, comparable to that achieved using an optical coherence tomography-based implementation of optical palpation. In this paper, we describe the fabrication of the micro-porous layer and present experimental results from structured phantoms containing stiff inclusions as small as 0.5 × 0.5 × 1 mm. In each case, we demonstrate high contrast between the inclusion and the base material and validate both the contrast and spatial resolution achieved using finite element modelling. By performing CBOP on freshly excised human breast tissue, we demonstrate the capability to delineate tumour from surrounding benign tissue.https://doi.org/10.1038/s41598-020-72603-5 |
| spellingShingle | Rowan W. Sanderson Qi Fang Andrea Curatolo Wayne Adams Devina D. Lakhiani Hina M. Ismail Ken Y. Foo Benjamin F. Dessauvagie Bruce Latham Chris Yeomans Christobel M. Saunders Brendan F. Kennedy Camera-based optical palpation Scientific Reports |
| title | Camera-based optical palpation |
| title_full | Camera-based optical palpation |
| title_fullStr | Camera-based optical palpation |
| title_full_unstemmed | Camera-based optical palpation |
| title_short | Camera-based optical palpation |
| title_sort | camera based optical palpation |
| url | https://doi.org/10.1038/s41598-020-72603-5 |
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