The Effects of Dexmedetomidine on Ischemia Reperfusion Injury in Patients Undergoing Arthroscopy Under Spinal Anesthesia
Objective: Ischemia and reperfusion injury due to tourniquet application during arthroscopy is a well known problem. This study aimed to compare the effects of dexmedetomidine and ketamine on hemodynamic and respiratory variables and on total anti-oxidant status (TAS), total oxidant status (TOS) and...
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| Format: | Article |
| Language: | English |
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AVES
2010-12-01
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| Series: | Eurasian Journal of Medicine |
| Subjects: | |
| Online Access: | http://www.eajm.org/text.php3?id=363 |
| _version_ | 1797913078821552128 |
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| author | Senem Koruk Ayse Mizrak Recai Kaya Berna Ugur Oguz Cebesoy Ahmet Celik Unsal Oner |
| author_facet | Senem Koruk Ayse Mizrak Recai Kaya Berna Ugur Oguz Cebesoy Ahmet Celik Unsal Oner |
| author_sort | Senem Koruk |
| collection | DOAJ |
| description | Objective: Ischemia and reperfusion injury due to tourniquet application during arthroscopy is a well known problem. This study aimed to compare the effects of dexmedetomidine and ketamine on hemodynamic and respiratory variables and on total anti-oxidant status (TAS), total oxidant status (TOS) and malondialdehyde (MDA) as markers of ischemia-reperfusion injury. Materials and Methods: This study was approved by a local ethics committee. The study was performed on patients undergoing arthroscopic operation under spinal anesthesia. Thirty patients were randomized into two groups: Group D (dexmedetomidine; n=15) and Group K (Ketamine; n=15). Spinal anesthesia at the L2-4 level was achieved using a 25G spinal needle with hyperbaric bupivacaine at a dose of 12-15 mg in all patients. In Group D, patients were sedated with dexmedetomidine at a dose of 0.3-0.5 µg/kg/h, while Group K received ketamine at a dose of 1-1.5 mg/kg/h. Hemodynamic parameters, oxygen saturation, Ramsey sedation scale (RSS), and TAS, TOS, and MDA levels were recorded. Results: Demographic parameters, TAS, TOS and MDA levels were similar between groups. In Group K, the TOS levels after tourniquet removal were significantly lower than at baseline and during the use of the tourniquet. Preoperative hemodynamic and respiratory variables were similar in both groups. Blood pressure values were decreased compared to baseline but these decreases were not statistically significant. Conclusion: In patients undergoing arthroscopy under spinal anesthesia, dexmedetomidine had effects similar to ketamine, led to insignificant alterations in hemodynamic and respiratory variables during surgery and had comparable effects on ischemia-reperfusion injury. Thus, we think that dexmedetomidine can be a safe alternative to ketamine as an intraoperative sedative. |
| first_indexed | 2024-04-10T12:06:13Z |
| format | Article |
| id | doaj.art-b190f94594824200b3bd86c2d9acebf6 |
| institution | Directory Open Access Journal |
| issn | 1308-8734 1308-8742 |
| language | English |
| last_indexed | 2024-04-10T12:06:13Z |
| publishDate | 2010-12-01 |
| publisher | AVES |
| record_format | Article |
| series | Eurasian Journal of Medicine |
| spelling | doaj.art-b190f94594824200b3bd86c2d9acebf62023-02-15T16:16:13ZengAVESEurasian Journal of Medicine1308-87341308-87422010-12-014203137141The Effects of Dexmedetomidine on Ischemia Reperfusion Injury in Patients Undergoing Arthroscopy Under Spinal AnesthesiaSenem KorukAyse MizrakRecai KayaBerna UgurOguz CebesoyAhmet CelikUnsal OnerObjective: Ischemia and reperfusion injury due to tourniquet application during arthroscopy is a well known problem. This study aimed to compare the effects of dexmedetomidine and ketamine on hemodynamic and respiratory variables and on total anti-oxidant status (TAS), total oxidant status (TOS) and malondialdehyde (MDA) as markers of ischemia-reperfusion injury. Materials and Methods: This study was approved by a local ethics committee. The study was performed on patients undergoing arthroscopic operation under spinal anesthesia. Thirty patients were randomized into two groups: Group D (dexmedetomidine; n=15) and Group K (Ketamine; n=15). Spinal anesthesia at the L2-4 level was achieved using a 25G spinal needle with hyperbaric bupivacaine at a dose of 12-15 mg in all patients. In Group D, patients were sedated with dexmedetomidine at a dose of 0.3-0.5 µg/kg/h, while Group K received ketamine at a dose of 1-1.5 mg/kg/h. Hemodynamic parameters, oxygen saturation, Ramsey sedation scale (RSS), and TAS, TOS, and MDA levels were recorded. Results: Demographic parameters, TAS, TOS and MDA levels were similar between groups. In Group K, the TOS levels after tourniquet removal were significantly lower than at baseline and during the use of the tourniquet. Preoperative hemodynamic and respiratory variables were similar in both groups. Blood pressure values were decreased compared to baseline but these decreases were not statistically significant. Conclusion: In patients undergoing arthroscopy under spinal anesthesia, dexmedetomidine had effects similar to ketamine, led to insignificant alterations in hemodynamic and respiratory variables during surgery and had comparable effects on ischemia-reperfusion injury. Thus, we think that dexmedetomidine can be a safe alternative to ketamine as an intraoperative sedative.http://www.eajm.org/text.php3?id=363DexmedetomidineKetamineIschemia reperfusionOxidative stress |
| spellingShingle | Senem Koruk Ayse Mizrak Recai Kaya Berna Ugur Oguz Cebesoy Ahmet Celik Unsal Oner The Effects of Dexmedetomidine on Ischemia Reperfusion Injury in Patients Undergoing Arthroscopy Under Spinal Anesthesia Eurasian Journal of Medicine Dexmedetomidine Ketamine Ischemia reperfusion Oxidative stress |
| title | The Effects of Dexmedetomidine on Ischemia Reperfusion Injury in Patients Undergoing Arthroscopy Under Spinal Anesthesia |
| title_full | The Effects of Dexmedetomidine on Ischemia Reperfusion Injury in Patients Undergoing Arthroscopy Under Spinal Anesthesia |
| title_fullStr | The Effects of Dexmedetomidine on Ischemia Reperfusion Injury in Patients Undergoing Arthroscopy Under Spinal Anesthesia |
| title_full_unstemmed | The Effects of Dexmedetomidine on Ischemia Reperfusion Injury in Patients Undergoing Arthroscopy Under Spinal Anesthesia |
| title_short | The Effects of Dexmedetomidine on Ischemia Reperfusion Injury in Patients Undergoing Arthroscopy Under Spinal Anesthesia |
| title_sort | effects of dexmedetomidine on ischemia reperfusion injury in patients undergoing arthroscopy under spinal anesthesia |
| topic | Dexmedetomidine Ketamine Ischemia reperfusion Oxidative stress |
| url | http://www.eajm.org/text.php3?id=363 |
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