Redox-Regulation in Cancer Stem Cells
Cancer stem cells (CSCs) represent a small subset of slowly dividing cells with tumor-initiating ability. They can self-renew and differentiate into all the distinct cell populations within a tumor. CSCs are naturally resistant to chemotherapy or radiotherapy. CSCs, thus, can repopulate a tumor afte...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/10/2413 |
| _version_ | 1797475088707092480 |
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| author | Uwe Lendeckel Carmen Wolke |
| author_facet | Uwe Lendeckel Carmen Wolke |
| author_sort | Uwe Lendeckel |
| collection | DOAJ |
| description | Cancer stem cells (CSCs) represent a small subset of slowly dividing cells with tumor-initiating ability. They can self-renew and differentiate into all the distinct cell populations within a tumor. CSCs are naturally resistant to chemotherapy or radiotherapy. CSCs, thus, can repopulate a tumor after therapy and are responsible for recurrence of disease. Stemness manifests itself through, among other things, the expression of stem cell markers, the ability to induce sphere formation and tumor growth in vivo, and resistance to chemotherapeutics and irradiation. Stemness is maintained by keeping levels of reactive oxygen species (ROS) low, which is achieved by enhanced activity of antioxidant pathways. Here, cellular sources of ROS, antioxidant pathways employed by CSCs, and underlying mechanisms to overcome resistance are discussed. |
| first_indexed | 2024-03-09T20:39:13Z |
| format | Article |
| id | doaj.art-b1924145b850429e979e51beb545cac4 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:39:13Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-b1924145b850429e979e51beb545cac42023-11-23T23:02:39ZengMDPI AGBiomedicines2227-90592022-09-011010241310.3390/biomedicines10102413Redox-Regulation in Cancer Stem CellsUwe Lendeckel0Carmen Wolke1Institute of Medical Biochemistry and Molecular Biology, University Medicine Greifswald, D-17475 Greifswald, GermanyInstitute of Medical Biochemistry and Molecular Biology, University Medicine Greifswald, D-17475 Greifswald, GermanyCancer stem cells (CSCs) represent a small subset of slowly dividing cells with tumor-initiating ability. They can self-renew and differentiate into all the distinct cell populations within a tumor. CSCs are naturally resistant to chemotherapy or radiotherapy. CSCs, thus, can repopulate a tumor after therapy and are responsible for recurrence of disease. Stemness manifests itself through, among other things, the expression of stem cell markers, the ability to induce sphere formation and tumor growth in vivo, and resistance to chemotherapeutics and irradiation. Stemness is maintained by keeping levels of reactive oxygen species (ROS) low, which is achieved by enhanced activity of antioxidant pathways. Here, cellular sources of ROS, antioxidant pathways employed by CSCs, and underlying mechanisms to overcome resistance are discussed.https://www.mdpi.com/2227-9059/10/10/2413antioxidant signaling pathwayscancer stem cellCD13drug resistanceSonic Hedgehog signalingNrf2-sinaling |
| spellingShingle | Uwe Lendeckel Carmen Wolke Redox-Regulation in Cancer Stem Cells Biomedicines antioxidant signaling pathways cancer stem cell CD13 drug resistance Sonic Hedgehog signaling Nrf2-sinaling |
| title | Redox-Regulation in Cancer Stem Cells |
| title_full | Redox-Regulation in Cancer Stem Cells |
| title_fullStr | Redox-Regulation in Cancer Stem Cells |
| title_full_unstemmed | Redox-Regulation in Cancer Stem Cells |
| title_short | Redox-Regulation in Cancer Stem Cells |
| title_sort | redox regulation in cancer stem cells |
| topic | antioxidant signaling pathways cancer stem cell CD13 drug resistance Sonic Hedgehog signaling Nrf2-sinaling |
| url | https://www.mdpi.com/2227-9059/10/10/2413 |
| work_keys_str_mv | AT uwelendeckel redoxregulationincancerstemcells AT carmenwolke redoxregulationincancerstemcells |