Alterations in cholesterol absorption/synthesis markers characterize Framingham Offspring Study participants with CHD[S]
Data is limited on measures influencing cholesterol homeostasis in subjects at high risk of developing cardiovascular disease (CVD) relative to established risk factors. To address this, we quantified circulating indicators of cholesterol homeostasis (plasma phytosterols and cholesterol precursor co...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2009-09-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520307458 |
| _version_ | 1818601014012411904 |
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| author | Nirupa R. Matthan Michael Pencina Jane M. LaRocque Paul F. Jacques Ralph B. D'Agostino Ernst J. Schaefer Alice H. Lichtenstein |
| author_facet | Nirupa R. Matthan Michael Pencina Jane M. LaRocque Paul F. Jacques Ralph B. D'Agostino Ernst J. Schaefer Alice H. Lichtenstein |
| author_sort | Nirupa R. Matthan |
| collection | DOAJ |
| description | Data is limited on measures influencing cholesterol homeostasis in subjects at high risk of developing cardiovascular disease (CVD) relative to established risk factors. To address this, we quantified circulating indicators of cholesterol homeostasis (plasma phytosterols and cholesterol precursor concentrations as surrogate measures of cholesterol absorption and synthesis, respectively) in Framingham Offspring Study Cycle-6 participants diagnosed with established CVD and/or ≥50% carotid stenosis not taking lipid lowering medication (cases, N = 155) and matched controls (N = 414). Cases and controls had similar plasma LDL-cholesterol; HDL-cholesterol was significantly lower in males, while triglyceride concentrations were significantly higher in female cases relative to their respective controls. Cholesterol absorption markers were significantly higher (229 ± 7 vs. 196 ± 4, 169 ± 6 vs. 149 ± 3 and 144 ± 5 vs. 135 ± 3 for campesterol, sitosterol, and cholestanol, respectively), whereas cholesterol synthesis markers were significantly lower (116 ± 4 vs. 138 ± 3, 73 ± 3 vs. 75 ± 2 for lathosterol and desmosterol, respectively) in cases compared with controls, irrespective of sex. After controlling for standard risk factors, campesterol (2.47 [1.71-3.56]; P < 0.0001), sitosterol (1.86 [1.38-2.50]; P < 0.0001), cholestanol (1.57 [1.09-2.27]; P = 0.02), desmosterol (0.59 [0.42-0.84]; P = 0.003), and lathosterol (0.58 [0.43-0.77]; P = 0.0002) were significantly associated with CVD (odds ratio [95% confidence interval]). These data suggest that impaired cholesterol homeostasis, reflected by lower synthesis and higher absorption marker concentrations, are highly significant independent predictors of prevalent CVD in this study population. |
| first_indexed | 2024-12-16T12:44:38Z |
| format | Article |
| id | doaj.art-b1930793a91d4730a497a9cf442c767f |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-16T12:44:38Z |
| publishDate | 2009-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-b1930793a91d4730a497a9cf442c767f2022-12-21T22:31:19ZengElsevierJournal of Lipid Research0022-22752009-09-0150919271935Alterations in cholesterol absorption/synthesis markers characterize Framingham Offspring Study participants with CHD[S]Nirupa R. Matthan0Michael Pencina1Jane M. LaRocque2Paul F. Jacques3Ralph B. D'Agostino4Ernst J. Schaefer5Alice H. Lichtenstein6To whom correspondence should be addressed.; Cardiovascular Nutrition, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston MAStatistics and Consulting Unit, Boston University, Boston MACardiovascular Nutrition, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston MANutritional Epidemiology, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston MAStatistics and Consulting Unit, Boston University, Boston MALipid Metabolism Laboratories, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston MACardiovascular Nutrition, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston MAData is limited on measures influencing cholesterol homeostasis in subjects at high risk of developing cardiovascular disease (CVD) relative to established risk factors. To address this, we quantified circulating indicators of cholesterol homeostasis (plasma phytosterols and cholesterol precursor concentrations as surrogate measures of cholesterol absorption and synthesis, respectively) in Framingham Offspring Study Cycle-6 participants diagnosed with established CVD and/or ≥50% carotid stenosis not taking lipid lowering medication (cases, N = 155) and matched controls (N = 414). Cases and controls had similar plasma LDL-cholesterol; HDL-cholesterol was significantly lower in males, while triglyceride concentrations were significantly higher in female cases relative to their respective controls. Cholesterol absorption markers were significantly higher (229 ± 7 vs. 196 ± 4, 169 ± 6 vs. 149 ± 3 and 144 ± 5 vs. 135 ± 3 for campesterol, sitosterol, and cholestanol, respectively), whereas cholesterol synthesis markers were significantly lower (116 ± 4 vs. 138 ± 3, 73 ± 3 vs. 75 ± 2 for lathosterol and desmosterol, respectively) in cases compared with controls, irrespective of sex. After controlling for standard risk factors, campesterol (2.47 [1.71-3.56]; P < 0.0001), sitosterol (1.86 [1.38-2.50]; P < 0.0001), cholestanol (1.57 [1.09-2.27]; P = 0.02), desmosterol (0.59 [0.42-0.84]; P = 0.003), and lathosterol (0.58 [0.43-0.77]; P = 0.0002) were significantly associated with CVD (odds ratio [95% confidence interval]). These data suggest that impaired cholesterol homeostasis, reflected by lower synthesis and higher absorption marker concentrations, are highly significant independent predictors of prevalent CVD in this study population.http://www.sciencedirect.com/science/article/pii/S0022227520307458lipidslipoproteinslathosteroldesmosterolphytosterolscampesterol |
| spellingShingle | Nirupa R. Matthan Michael Pencina Jane M. LaRocque Paul F. Jacques Ralph B. D'Agostino Ernst J. Schaefer Alice H. Lichtenstein Alterations in cholesterol absorption/synthesis markers characterize Framingham Offspring Study participants with CHD[S] Journal of Lipid Research lipids lipoproteins lathosterol desmosterol phytosterols campesterol |
| title | Alterations in cholesterol absorption/synthesis markers characterize Framingham Offspring Study participants with CHD[S] |
| title_full | Alterations in cholesterol absorption/synthesis markers characterize Framingham Offspring Study participants with CHD[S] |
| title_fullStr | Alterations in cholesterol absorption/synthesis markers characterize Framingham Offspring Study participants with CHD[S] |
| title_full_unstemmed | Alterations in cholesterol absorption/synthesis markers characterize Framingham Offspring Study participants with CHD[S] |
| title_short | Alterations in cholesterol absorption/synthesis markers characterize Framingham Offspring Study participants with CHD[S] |
| title_sort | alterations in cholesterol absorption synthesis markers characterize framingham offspring study participants with chd s |
| topic | lipids lipoproteins lathosterol desmosterol phytosterols campesterol |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520307458 |
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