Research progress on emulsion vaccine adjuvants
Vaccination is the most cost-effective method for preventing various infectious diseases. Compared with conventional vaccines, new-generation vaccines, especially recombinant protein or synthetic peptide vaccines, are safer but less immunogenic than crude inactivated microbial vaccines. The immunoge...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024006935 |
| _version_ | 1797304574152802304 |
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| author | Zhuanqing Huang Hui Gong Qi Sun Jinjin Yang Xiaochuan Yan Fenghua Xu |
| author_facet | Zhuanqing Huang Hui Gong Qi Sun Jinjin Yang Xiaochuan Yan Fenghua Xu |
| author_sort | Zhuanqing Huang |
| collection | DOAJ |
| description | Vaccination is the most cost-effective method for preventing various infectious diseases. Compared with conventional vaccines, new-generation vaccines, especially recombinant protein or synthetic peptide vaccines, are safer but less immunogenic than crude inactivated microbial vaccines. The immunogenicity of these vaccines can be enhanced using suitable adjuvants. This is the main reason why adjuvants are of great importance in vaccine development. Several novel human emulsion-based vaccine adjuvants (MF59, AS03) have been approved for clinical use. This paper reviews the research progress on emulsion-based adjuvants and focuses on their mechanism of action. An outlook can be provided for the development of emulsion-based vaccine adjuvants. |
| first_indexed | 2024-03-08T00:12:23Z |
| format | Article |
| id | doaj.art-b1953119b0774a129959a3b519f5190b |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T00:12:23Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-b1953119b0774a129959a3b519f5190b2024-02-17T06:38:24ZengElsevierHeliyon2405-84402024-02-01103e24662Research progress on emulsion vaccine adjuvantsZhuanqing Huang0Hui Gong1Qi Sun2Jinjin Yang3Xiaochuan Yan4Fenghua Xu5Department of Ophthalmology, The No. 944 Hospital of Joint Logistic Support Force of PLA, Gansu 735000, China; Pharmaceutical Sciences Research Division, Department of Pharmacy, Medical Supplies Centre, PLA General Hospital, Beijing 100853, ChinaMedical School of Chinese PLA, Beijing 100853, ChinaPharmaceutical Sciences Research Division, Department of Pharmacy, Medical Supplies Centre, PLA General Hospital, Beijing 100853, ChinaThe Fifth medical center of Chinese PLA General Hospital, Beijing 100071, ChinaDepartment of Ophthalmology, The No. 944 Hospital of Joint Logistic Support Force of PLA, Gansu 735000, China; Corresponding author.Pharmaceutical Sciences Research Division, Department of Pharmacy, Medical Supplies Centre, PLA General Hospital, Beijing 100853, China; Corresponding author.Vaccination is the most cost-effective method for preventing various infectious diseases. Compared with conventional vaccines, new-generation vaccines, especially recombinant protein or synthetic peptide vaccines, are safer but less immunogenic than crude inactivated microbial vaccines. The immunogenicity of these vaccines can be enhanced using suitable adjuvants. This is the main reason why adjuvants are of great importance in vaccine development. Several novel human emulsion-based vaccine adjuvants (MF59, AS03) have been approved for clinical use. This paper reviews the research progress on emulsion-based adjuvants and focuses on their mechanism of action. An outlook can be provided for the development of emulsion-based vaccine adjuvants.http://www.sciencedirect.com/science/article/pii/S2405844024006935Emulsion-based adjuvantImmunisationVaccine |
| spellingShingle | Zhuanqing Huang Hui Gong Qi Sun Jinjin Yang Xiaochuan Yan Fenghua Xu Research progress on emulsion vaccine adjuvants Heliyon Emulsion-based adjuvant Immunisation Vaccine |
| title | Research progress on emulsion vaccine adjuvants |
| title_full | Research progress on emulsion vaccine adjuvants |
| title_fullStr | Research progress on emulsion vaccine adjuvants |
| title_full_unstemmed | Research progress on emulsion vaccine adjuvants |
| title_short | Research progress on emulsion vaccine adjuvants |
| title_sort | research progress on emulsion vaccine adjuvants |
| topic | Emulsion-based adjuvant Immunisation Vaccine |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024006935 |
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