Strategies to Build Hybrid Protein–DNA Nanostructures
Proteins and DNA exhibit key physical chemical properties that make them advantageous for building nanostructures with outstanding features. Both DNA and protein nanotechnology have growth notably and proved to be fertile disciplines. The combination of both types of nanotechnologies is helpful to o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/5/1332 |
| _version_ | 1827692223368527872 |
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| author | Armando Hernandez-Garcia |
| author_facet | Armando Hernandez-Garcia |
| author_sort | Armando Hernandez-Garcia |
| collection | DOAJ |
| description | Proteins and DNA exhibit key physical chemical properties that make them advantageous for building nanostructures with outstanding features. Both DNA and protein nanotechnology have growth notably and proved to be fertile disciplines. The combination of both types of nanotechnologies is helpful to overcome the individual weaknesses and limitations of each one, paving the way for the continuing diversification of structural nanotechnologies. Recent studies have implemented a synergistic combination of both biomolecules to assemble unique and sophisticate protein–DNA nanostructures. These hybrid nanostructures are highly programmable and display remarkable features that create new opportunities to build on the nanoscale. This review focuses on the strategies deployed to create hybrid protein–DNA nanostructures. Here, we discuss strategies such as polymerization, spatial directing and organizing, coating, and rigidizing or folding DNA into particular shapes or moving parts. The enrichment of structural DNA nanotechnology by incorporating protein nanotechnology has been clearly demonstrated and still shows a large potential to create useful and advanced materials with cell-like properties or dynamic systems. It can be expected that structural protein–DNA nanotechnology will open new avenues in the fabrication of nanoassemblies with unique functional applications and enrich the toolbox of bionanotechnology. |
| first_indexed | 2024-03-10T11:17:23Z |
| format | Article |
| id | doaj.art-b197a62e066944bcbfac85bd38500af0 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T11:17:23Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-b197a62e066944bcbfac85bd38500af02023-11-21T20:18:15ZengMDPI AGNanomaterials2079-49912021-05-01115133210.3390/nano11051332Strategies to Build Hybrid Protein–DNA NanostructuresArmando Hernandez-Garcia0Laboratory of Biomolecular Engineering and Bionanotechnology, Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México 04510, MexicoProteins and DNA exhibit key physical chemical properties that make them advantageous for building nanostructures with outstanding features. Both DNA and protein nanotechnology have growth notably and proved to be fertile disciplines. The combination of both types of nanotechnologies is helpful to overcome the individual weaknesses and limitations of each one, paving the way for the continuing diversification of structural nanotechnologies. Recent studies have implemented a synergistic combination of both biomolecules to assemble unique and sophisticate protein–DNA nanostructures. These hybrid nanostructures are highly programmable and display remarkable features that create new opportunities to build on the nanoscale. This review focuses on the strategies deployed to create hybrid protein–DNA nanostructures. Here, we discuss strategies such as polymerization, spatial directing and organizing, coating, and rigidizing or folding DNA into particular shapes or moving parts. The enrichment of structural DNA nanotechnology by incorporating protein nanotechnology has been clearly demonstrated and still shows a large potential to create useful and advanced materials with cell-like properties or dynamic systems. It can be expected that structural protein–DNA nanotechnology will open new avenues in the fabrication of nanoassemblies with unique functional applications and enrich the toolbox of bionanotechnology.https://www.mdpi.com/2079-4991/11/5/1332DNA nanotechnologyprotein nanotechnologyself-assemblybionanomaterials |
| spellingShingle | Armando Hernandez-Garcia Strategies to Build Hybrid Protein–DNA Nanostructures Nanomaterials DNA nanotechnology protein nanotechnology self-assembly bionanomaterials |
| title | Strategies to Build Hybrid Protein–DNA Nanostructures |
| title_full | Strategies to Build Hybrid Protein–DNA Nanostructures |
| title_fullStr | Strategies to Build Hybrid Protein–DNA Nanostructures |
| title_full_unstemmed | Strategies to Build Hybrid Protein–DNA Nanostructures |
| title_short | Strategies to Build Hybrid Protein–DNA Nanostructures |
| title_sort | strategies to build hybrid protein dna nanostructures |
| topic | DNA nanotechnology protein nanotechnology self-assembly bionanomaterials |
| url | https://www.mdpi.com/2079-4991/11/5/1332 |
| work_keys_str_mv | AT armandohernandezgarcia strategiestobuildhybridproteindnananostructures |