CD8+ tumor‐infiltrating lymphocytes within the primary tumor of patients with synchronous de novo metastatic colorectal carcinoma do not track with survival

CD8+ tumor‐infiltrating lymphocytes within the primary tumor of patients with synchronous de novo metastatic colorectal carcinoma do not track with survival

Abstract Objectives Tumor‐infiltrating lymphocytes (TIL), particularly CD8+ TILs in patients with colorectal cancer (CRC), are highly prognostic in the early‐disease stages (I‐II). In metastatic disease (stage IV; mCRC), their influence is less well defined. It has presumably failed to contain tumor...

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Bibliographic Details
Main Authors: Rosemary Millen, Shona Hendry, Vignesh Narasimhan, Rebecca Abbott, Matthew Croxford, Peter Gibbs, Jeanne Tie, Hui‐Li Wong, Ian Jones, Suzanne Kosmider, David Byrne, John Zalcberg, Stephen Fox, Jayesh Desai, Kumar Visvanathan, Robert G Ramsay, Ben Tran
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Clinical & Translational Immunology
Subjects:
advanced metastatic colorectal cancer
PD‐L1
tumor infiltrating lymphocytes
Online Access:https://doi.org/10.1002/cti2.1155

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