Butyrate suppresses atherosclerotic inflammation by regulating macrophages and polarization via GPR43/HDAC-miRNAs axis in ApoE-/- mice.

Butyrate suppresses atherosclerotic inflammation by regulating macrophages and polarization via GPR43/HDAC-miRNAs axis in ApoE-/- mice.

Chronic low-grade inflammation is regarded to an important signature of atherosclerosis (AS). Macrophage (Mψ) and related polarization have been demonstrated to play a crucial role in the occurrence and development of AS inflammation. Butyrate, a bioactive molecule produced by the intestinal flora,...

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Bibliographic Details
Main Authors: Huiyan Ma, Libo Yang, Yajuan Liu, Ru Yan, Rui Wang, Peng Zhang, Zhixia Bai, Yuanyuan Liu, Yi Ren, Yiwei Li, Xin Jiang, Ting Wang, Ping Ma, Qining Zhang, Aifei Li, Mixue Guo, Xiaoxia Zhang, Shaobin Jia, Hao Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0282685

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