Levonorgestrel intrauterine system versus oral progestin for preventing the recurrence of endometrial polyps after hysteroscopic resection: A meta-analysis of 19 randomized controlled trials
Background: The aim of this meta-analysis was to compare levonorgestrel intrauterine system (LNG-IUS) with oral progestin for preventing the recurrence of endometrial polyps after hysteroscopic resection. Materials and Methods: Computerized literature search was performed in PubMed and several Chine...
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| Format: | Article |
| Language: | English |
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IMR Press
2020-12-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/47/6/10.31083/j.ceog.2020.06.5387 |
| _version_ | 1828810918587269120 |
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| author | Y. Sun X. Chen X. Yuan L. Xu Y.C. Jin T.H. Ji X.L. Wang H.H. Dai W.J. Cheng |
| author_facet | Y. Sun X. Chen X. Yuan L. Xu Y.C. Jin T.H. Ji X.L. Wang H.H. Dai W.J. Cheng |
| author_sort | Y. Sun |
| collection | DOAJ |
| description | Background: The aim of this meta-analysis was to compare levonorgestrel intrauterine system (LNG-IUS) with oral progestin for preventing the recurrence of endometrial polyps after hysteroscopic resection. Materials and Methods: Computerized literature search was performed in PubMed and several Chinese databases to screen for relevant trials. Quality assessment and meta-analysis were performed for the included trials. Results: A total of 19 randomized controlled trials were identified. Meta-analysis indicated that the LNG-IUS group was associated with lower recurrence rate of endometrial polyps than the oral progestin group (p < 0.0001), while there was no significant difference in the incidence of abnormal uterine bleeding between groups (p > 0.05). In terms of adverse effects related to progestin, the LNG-IUS group had significantly fewer adverse effects than the oral progestin group (p < 0.0001). Additionally, the LNG-IUS group had thinner endometrium and higher hemoglobin levels than the oral progestin group (p < 0.00001). Conclusion: The LNG-IUS was more effective and safer in preventing the recurrence of endometrial polyps after hysteroscopic resection than oral progestin. |
| first_indexed | 2024-12-12T09:19:12Z |
| format | Article |
| id | doaj.art-b19ce9c337304a8bb364ae89dfb99ca0 |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-12-12T09:19:12Z |
| publishDate | 2020-12-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-b19ce9c337304a8bb364ae89dfb99ca02022-12-22T00:29:17ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632020-12-0147682182810.31083/j.ceog.2020.06.5387S0390-6663(20)00317-6Levonorgestrel intrauterine system versus oral progestin for preventing the recurrence of endometrial polyps after hysteroscopic resection: A meta-analysis of 19 randomized controlled trialsY. Sun0X. Chen1X. Yuan2L. Xu3Y.C. Jin4T.H. Ji5X.L. Wang6H.H. Dai7W.J. Cheng8Department of Gynecology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. ChinaDepartment of Gynecology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. ChinaDepartment of Gynecology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. ChinaDepartment of Gynecology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. ChinaDepartment of Gynecology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. ChinaDepartment of Gynecology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. ChinaDepartment of Gynecology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. ChinaDepartment of Gynecology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. ChinaDepartment of Gynecology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. ChinaBackground: The aim of this meta-analysis was to compare levonorgestrel intrauterine system (LNG-IUS) with oral progestin for preventing the recurrence of endometrial polyps after hysteroscopic resection. Materials and Methods: Computerized literature search was performed in PubMed and several Chinese databases to screen for relevant trials. Quality assessment and meta-analysis were performed for the included trials. Results: A total of 19 randomized controlled trials were identified. Meta-analysis indicated that the LNG-IUS group was associated with lower recurrence rate of endometrial polyps than the oral progestin group (p < 0.0001), while there was no significant difference in the incidence of abnormal uterine bleeding between groups (p > 0.05). In terms of adverse effects related to progestin, the LNG-IUS group had significantly fewer adverse effects than the oral progestin group (p < 0.0001). Additionally, the LNG-IUS group had thinner endometrium and higher hemoglobin levels than the oral progestin group (p < 0.00001). Conclusion: The LNG-IUS was more effective and safer in preventing the recurrence of endometrial polyps after hysteroscopic resection than oral progestin.https://www.imrpress.com/journal/CEOG/47/6/10.31083/j.ceog.2020.06.5387endometrial polypslevonorgestrel intrauterine systemlng-iusoral progestinmeta-analysis |
| spellingShingle | Y. Sun X. Chen X. Yuan L. Xu Y.C. Jin T.H. Ji X.L. Wang H.H. Dai W.J. Cheng Levonorgestrel intrauterine system versus oral progestin for preventing the recurrence of endometrial polyps after hysteroscopic resection: A meta-analysis of 19 randomized controlled trials Clinical and Experimental Obstetrics & Gynecology endometrial polyps levonorgestrel intrauterine system lng-ius oral progestin meta-analysis |
| title | Levonorgestrel intrauterine system versus oral progestin for preventing the recurrence of endometrial polyps after hysteroscopic resection: A meta-analysis of 19 randomized controlled trials |
| title_full | Levonorgestrel intrauterine system versus oral progestin for preventing the recurrence of endometrial polyps after hysteroscopic resection: A meta-analysis of 19 randomized controlled trials |
| title_fullStr | Levonorgestrel intrauterine system versus oral progestin for preventing the recurrence of endometrial polyps after hysteroscopic resection: A meta-analysis of 19 randomized controlled trials |
| title_full_unstemmed | Levonorgestrel intrauterine system versus oral progestin for preventing the recurrence of endometrial polyps after hysteroscopic resection: A meta-analysis of 19 randomized controlled trials |
| title_short | Levonorgestrel intrauterine system versus oral progestin for preventing the recurrence of endometrial polyps after hysteroscopic resection: A meta-analysis of 19 randomized controlled trials |
| title_sort | levonorgestrel intrauterine system versus oral progestin for preventing the recurrence of endometrial polyps after hysteroscopic resection a meta analysis of 19 randomized controlled trials |
| topic | endometrial polyps levonorgestrel intrauterine system lng-ius oral progestin meta-analysis |
| url | https://www.imrpress.com/journal/CEOG/47/6/10.31083/j.ceog.2020.06.5387 |
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