Extracellular Vesicles in Trypanosoma cruzi Infection: Immunomodulatory Effects and Future Perspectives as Potential Control Tools against Chagas Disease
Chagas disease, caused by the protozoa parasite Trypanosoma cruzi, is a neglected tropical disease and a major public health problem affecting more than 6 million people worldwide. Many challenges remain in the quest to control Chagas disease: the diagnosis presents several limitations and the two a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2022-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/5230603 |
| _version_ | 1811183236261347328 |
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| author | Nuria Cortes-Serra Melisa Gualdron-Lopez Maria-Jesus Pinazo Ana Claudia Torrecilhas Carmen Fernandez-Becerra |
| author_facet | Nuria Cortes-Serra Melisa Gualdron-Lopez Maria-Jesus Pinazo Ana Claudia Torrecilhas Carmen Fernandez-Becerra |
| author_sort | Nuria Cortes-Serra |
| collection | DOAJ |
| description | Chagas disease, caused by the protozoa parasite Trypanosoma cruzi, is a neglected tropical disease and a major public health problem affecting more than 6 million people worldwide. Many challenges remain in the quest to control Chagas disease: the diagnosis presents several limitations and the two available treatments cause several side effects, presenting limited efficacy during the chronic phase of the disease. In addition, there are no preventive vaccines or biomarkers of therapeutic response or disease outcome. Trypomastigote form and T. cruzi-infected cells release extracellular vesicles (EVs), which are involved in cell-to-cell communication and can modulate the host immune response. Importantly, EVs have been described as promising tools for the development of new therapeutic strategies, such as vaccines, and for the discovery of new biomarkers. Here, we review and discuss the role of EVs secreted during T. cruzi infection and their immunomodulatory properties. Finally, we briefly describe their potential for biomarker discovery and future perspectives as vaccine development tools for Chagas Disease. |
| first_indexed | 2024-04-11T09:44:29Z |
| format | Article |
| id | doaj.art-b19d45100776477aa2802d1e275676aa |
| institution | Directory Open Access Journal |
| issn | 2314-7156 |
| language | English |
| last_indexed | 2024-04-11T09:44:29Z |
| publishDate | 2022-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj.art-b19d45100776477aa2802d1e275676aa2022-12-22T04:31:07ZengHindawi LimitedJournal of Immunology Research2314-71562022-01-01202210.1155/2022/5230603Extracellular Vesicles in Trypanosoma cruzi Infection: Immunomodulatory Effects and Future Perspectives as Potential Control Tools against Chagas DiseaseNuria Cortes-Serra0Melisa Gualdron-Lopez1Maria-Jesus Pinazo2Ana Claudia Torrecilhas3Carmen Fernandez-Becerra4ISGlobalISGlobalISGlobalLaboratório de Imunologia Celular e Bioquímica de Fungos e ProtozoáriosISGlobalChagas disease, caused by the protozoa parasite Trypanosoma cruzi, is a neglected tropical disease and a major public health problem affecting more than 6 million people worldwide. Many challenges remain in the quest to control Chagas disease: the diagnosis presents several limitations and the two available treatments cause several side effects, presenting limited efficacy during the chronic phase of the disease. In addition, there are no preventive vaccines or biomarkers of therapeutic response or disease outcome. Trypomastigote form and T. cruzi-infected cells release extracellular vesicles (EVs), which are involved in cell-to-cell communication and can modulate the host immune response. Importantly, EVs have been described as promising tools for the development of new therapeutic strategies, such as vaccines, and for the discovery of new biomarkers. Here, we review and discuss the role of EVs secreted during T. cruzi infection and their immunomodulatory properties. Finally, we briefly describe their potential for biomarker discovery and future perspectives as vaccine development tools for Chagas Disease.http://dx.doi.org/10.1155/2022/5230603 |
| spellingShingle | Nuria Cortes-Serra Melisa Gualdron-Lopez Maria-Jesus Pinazo Ana Claudia Torrecilhas Carmen Fernandez-Becerra Extracellular Vesicles in Trypanosoma cruzi Infection: Immunomodulatory Effects and Future Perspectives as Potential Control Tools against Chagas Disease Journal of Immunology Research |
| title | Extracellular Vesicles in Trypanosoma cruzi Infection: Immunomodulatory Effects and Future Perspectives as Potential Control Tools against Chagas Disease |
| title_full | Extracellular Vesicles in Trypanosoma cruzi Infection: Immunomodulatory Effects and Future Perspectives as Potential Control Tools against Chagas Disease |
| title_fullStr | Extracellular Vesicles in Trypanosoma cruzi Infection: Immunomodulatory Effects and Future Perspectives as Potential Control Tools against Chagas Disease |
| title_full_unstemmed | Extracellular Vesicles in Trypanosoma cruzi Infection: Immunomodulatory Effects and Future Perspectives as Potential Control Tools against Chagas Disease |
| title_short | Extracellular Vesicles in Trypanosoma cruzi Infection: Immunomodulatory Effects and Future Perspectives as Potential Control Tools against Chagas Disease |
| title_sort | extracellular vesicles in trypanosoma cruzi infection immunomodulatory effects and future perspectives as potential control tools against chagas disease |
| url | http://dx.doi.org/10.1155/2022/5230603 |
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