Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19
Background: In healthy pregnancies, components of the Renin-Angiotensin system (RAS) are present in the placental villi and contribute to invasion, migration, and angiogenesis. At the same time, soluble fms-like tyrosine kinase 1 (sFlt-1) production is induced after binding of ANG-II to its receptor...
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| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/10/1906 |
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| author | Salvador Espino-y-Sosa Raigam Jafet Martinez-Portilla Johnatan Torres-Torres Juan Mario Solis-Paredes Guadalupe Estrada-Gutierrez Jose Antonio Hernandez-Pacheco Aurora Espejel-Nuñez Paloma Mateu-Rogell Angeles Juarez-Reyes Francisco Eduardo Lopez-Ceh Jose Rafael Villafan-Bernal Lourdes Rojas-Zepeda Iris Paola Guzman-Guzman Liona C. Poon |
| author_facet | Salvador Espino-y-Sosa Raigam Jafet Martinez-Portilla Johnatan Torres-Torres Juan Mario Solis-Paredes Guadalupe Estrada-Gutierrez Jose Antonio Hernandez-Pacheco Aurora Espejel-Nuñez Paloma Mateu-Rogell Angeles Juarez-Reyes Francisco Eduardo Lopez-Ceh Jose Rafael Villafan-Bernal Lourdes Rojas-Zepeda Iris Paola Guzman-Guzman Liona C. Poon |
| author_sort | Salvador Espino-y-Sosa |
| collection | DOAJ |
| description | Background: In healthy pregnancies, components of the Renin-Angiotensin system (RAS) are present in the placental villi and contribute to invasion, migration, and angiogenesis. At the same time, soluble fms-like tyrosine kinase 1 (sFlt-1) production is induced after binding of ANG-II to its receptor (AT-1R) in response to hypoxia. As RAS plays an essential role in the pathogenesis of COVID-19, we hypothesized that angiogenic marker (sFlt-1) and RAS components (ANG-II and ACE-2) may be related to adverse outcomes in pregnant women with COVID-19; Methods: Prospective cohort study. Primary outcome was severe pneumonia. Secondary outcomes were ICU admission, intubation, sepsis, and death. Spearman’s Rho test was used to analyze the correlation between sFlt-1 and ANG-II levels. The sFlt-1/ANG-II ratio was determined and the association with each adverse outcome was explored by logistic regression analysis and the prediction was assessed using receiver-operating-curve (ROC); Results: Among 80 pregnant women with COVID-19, the sFlt-1/ANG-II ratio was associated with an increased probability of severe pneumonia (odds ratio [OR]: 1.31; <i>p</i> = 0.003), ICU admission (OR: 1.05; <i>p</i> = 0.007); intubation (OR: 1.09; <i>p</i> = 0.008); sepsis (OR: 1.04; <i>p</i> = 0.008); and death (OR: 1.04; <i>p</i> = 0.018); Conclusion: sFlt-1/ANG-II ratio is a good predictor of adverse events such as pneumonia, ICU admission, intubation, sepsis, and death in pregnant women with COVID-19. |
| first_indexed | 2024-03-10T06:09:44Z |
| format | Article |
| id | doaj.art-b19d5364048d479fb8dbeea3e430bf96 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T06:09:44Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-b19d5364048d479fb8dbeea3e430bf962023-11-22T20:17:51ZengMDPI AGViruses1999-49152021-09-011310190610.3390/v13101906Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19Salvador Espino-y-Sosa0Raigam Jafet Martinez-Portilla1Johnatan Torres-Torres2Juan Mario Solis-Paredes3Guadalupe Estrada-Gutierrez4Jose Antonio Hernandez-Pacheco5Aurora Espejel-Nuñez6Paloma Mateu-Rogell7Angeles Juarez-Reyes8Francisco Eduardo Lopez-Ceh9Jose Rafael Villafan-Bernal10Lourdes Rojas-Zepeda11Iris Paola Guzman-Guzman12Liona C. Poon13Clinical Research Deparment, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City 11000, MexicoClinical Research Deparment, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City 11000, MexicoClinical Research Deparment, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City 11000, MexicoClinical Research Deparment, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City 11000, MexicoClinical Research Deparment, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City 11000, MexicoClinical Research Deparment, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City 11000, MexicoClinical Research Deparment, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City 11000, MexicoClinical Research Deparment, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City 11000, MexicoMaternal Fetal Medicine Department, Hospital General de Mexico, “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoMaternal Fetal Medicine Department, Hospital General de Mexico, “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoIberoamerican Research Network in Obstetrics, Gynecology and Translational Medicine, Mexico City 06720, MexicoMaternal Fetal Medicine Department, Instituto Materno Infantil del Estado de Mexico, Mexico City 50170, MexicoFaculty of Chemical-Biological Sciences, Autonomous University of Guerrero, Chilpancingo 39086, MexicoDepartment of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, ChinaBackground: In healthy pregnancies, components of the Renin-Angiotensin system (RAS) are present in the placental villi and contribute to invasion, migration, and angiogenesis. At the same time, soluble fms-like tyrosine kinase 1 (sFlt-1) production is induced after binding of ANG-II to its receptor (AT-1R) in response to hypoxia. As RAS plays an essential role in the pathogenesis of COVID-19, we hypothesized that angiogenic marker (sFlt-1) and RAS components (ANG-II and ACE-2) may be related to adverse outcomes in pregnant women with COVID-19; Methods: Prospective cohort study. Primary outcome was severe pneumonia. Secondary outcomes were ICU admission, intubation, sepsis, and death. Spearman’s Rho test was used to analyze the correlation between sFlt-1 and ANG-II levels. The sFlt-1/ANG-II ratio was determined and the association with each adverse outcome was explored by logistic regression analysis and the prediction was assessed using receiver-operating-curve (ROC); Results: Among 80 pregnant women with COVID-19, the sFlt-1/ANG-II ratio was associated with an increased probability of severe pneumonia (odds ratio [OR]: 1.31; <i>p</i> = 0.003), ICU admission (OR: 1.05; <i>p</i> = 0.007); intubation (OR: 1.09; <i>p</i> = 0.008); sepsis (OR: 1.04; <i>p</i> = 0.008); and death (OR: 1.04; <i>p</i> = 0.018); Conclusion: sFlt-1/ANG-II ratio is a good predictor of adverse events such as pneumonia, ICU admission, intubation, sepsis, and death in pregnant women with COVID-19.https://www.mdpi.com/1999-4915/13/10/1906COVID-19maternal deathangiotensin-IIsFlt-1 |
| spellingShingle | Salvador Espino-y-Sosa Raigam Jafet Martinez-Portilla Johnatan Torres-Torres Juan Mario Solis-Paredes Guadalupe Estrada-Gutierrez Jose Antonio Hernandez-Pacheco Aurora Espejel-Nuñez Paloma Mateu-Rogell Angeles Juarez-Reyes Francisco Eduardo Lopez-Ceh Jose Rafael Villafan-Bernal Lourdes Rojas-Zepeda Iris Paola Guzman-Guzman Liona C. Poon Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19 Viruses COVID-19 maternal death angiotensin-II sFlt-1 |
| title | Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19 |
| title_full | Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19 |
| title_fullStr | Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19 |
| title_full_unstemmed | Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19 |
| title_short | Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19 |
| title_sort | novel ratio soluble fms like tyrosine kinase 1 angiotensin ii sflt 1 ang ii in pregnant women is associated with critical illness in covid 19 |
| topic | COVID-19 maternal death angiotensin-II sFlt-1 |
| url | https://www.mdpi.com/1999-4915/13/10/1906 |
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