The Influence of Sex on Characteristics and Outcomes of Coronavirus-19 Patients: A Retrospective Cohort Study
Background: The influence of sex on the clinical characteristics and prognosis of coronavirus disease (COVID-19) patients is variable. This study aimed to evaluate COVID-19 management based on sex differences. Methods: We retrospectively reviewed COVID-19 patients who were admitted to the tertiary h...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/12/3/1118 |
| _version_ | 1797624077524926464 |
|---|---|
| author | Song-I Lee Chaeuk Chung Dongil Park Da Hyun Kang Ye-Rin Ju Jeong Eun Lee |
| author_facet | Song-I Lee Chaeuk Chung Dongil Park Da Hyun Kang Ye-Rin Ju Jeong Eun Lee |
| author_sort | Song-I Lee |
| collection | DOAJ |
| description | Background: The influence of sex on the clinical characteristics and prognosis of coronavirus disease (COVID-19) patients is variable. This study aimed to evaluate COVID-19 management based on sex differences. Methods: We retrospectively reviewed COVID-19 patients who were admitted to the tertiary hospital between January 2020 and March 2021. Logistic regression analysis was used to evaluate the factors associated with in-hospital mortality. Results: During the study period, 584 patients were admitted to our hospital. Among them, 305 patients (52.2%) were female, and 279 patients (47.8%) were male. Males were younger than females, and frailty scale was lower in males than in females. Fever was more common in males, and there was no difference in other initial symptoms. Among the underlying comorbidities, chronic obstructive disease was more common in males, and there were no significant differences in other comorbidities. Moreover, treatment, severity, and outcome did not significantly differ between the groups. The risk factors for in-hospital mortality were age, high white blood cell count, and c-reactive protein level. Conclusions: We found no definite sex differences in the clinical characteristics and outcomes of COVID-19 patients. However, a better understanding of sex-dependent differences in COVID-19 patients could help in understanding and treating patients. |
| first_indexed | 2024-03-11T09:38:13Z |
| format | Article |
| id | doaj.art-b19eaf5ca6b548f98e279fb04399ba10 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T09:38:13Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-b19eaf5ca6b548f98e279fb04399ba102023-11-16T17:12:01ZengMDPI AGJournal of Clinical Medicine2077-03832023-01-01123111810.3390/jcm12031118The Influence of Sex on Characteristics and Outcomes of Coronavirus-19 Patients: A Retrospective Cohort StudySong-I Lee0Chaeuk Chung1Dongil Park2Da Hyun Kang3Ye-Rin Ju4Jeong Eun Lee5Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon 35015, Republic of KoreaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon 35015, Republic of KoreaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon 35015, Republic of KoreaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon 35015, Republic of KoreaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon 35015, Republic of KoreaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon 35015, Republic of KoreaBackground: The influence of sex on the clinical characteristics and prognosis of coronavirus disease (COVID-19) patients is variable. This study aimed to evaluate COVID-19 management based on sex differences. Methods: We retrospectively reviewed COVID-19 patients who were admitted to the tertiary hospital between January 2020 and March 2021. Logistic regression analysis was used to evaluate the factors associated with in-hospital mortality. Results: During the study period, 584 patients were admitted to our hospital. Among them, 305 patients (52.2%) were female, and 279 patients (47.8%) were male. Males were younger than females, and frailty scale was lower in males than in females. Fever was more common in males, and there was no difference in other initial symptoms. Among the underlying comorbidities, chronic obstructive disease was more common in males, and there were no significant differences in other comorbidities. Moreover, treatment, severity, and outcome did not significantly differ between the groups. The risk factors for in-hospital mortality were age, high white blood cell count, and c-reactive protein level. Conclusions: We found no definite sex differences in the clinical characteristics and outcomes of COVID-19 patients. However, a better understanding of sex-dependent differences in COVID-19 patients could help in understanding and treating patients.https://www.mdpi.com/2077-0383/12/3/1118COVID-19sexoutcome |
| spellingShingle | Song-I Lee Chaeuk Chung Dongil Park Da Hyun Kang Ye-Rin Ju Jeong Eun Lee The Influence of Sex on Characteristics and Outcomes of Coronavirus-19 Patients: A Retrospective Cohort Study Journal of Clinical Medicine COVID-19 sex outcome |
| title | The Influence of Sex on Characteristics and Outcomes of Coronavirus-19 Patients: A Retrospective Cohort Study |
| title_full | The Influence of Sex on Characteristics and Outcomes of Coronavirus-19 Patients: A Retrospective Cohort Study |
| title_fullStr | The Influence of Sex on Characteristics and Outcomes of Coronavirus-19 Patients: A Retrospective Cohort Study |
| title_full_unstemmed | The Influence of Sex on Characteristics and Outcomes of Coronavirus-19 Patients: A Retrospective Cohort Study |
| title_short | The Influence of Sex on Characteristics and Outcomes of Coronavirus-19 Patients: A Retrospective Cohort Study |
| title_sort | influence of sex on characteristics and outcomes of coronavirus 19 patients a retrospective cohort study |
| topic | COVID-19 sex outcome |
| url | https://www.mdpi.com/2077-0383/12/3/1118 |
| work_keys_str_mv | AT songilee theinfluenceofsexoncharacteristicsandoutcomesofcoronavirus19patientsaretrospectivecohortstudy AT chaeukchung theinfluenceofsexoncharacteristicsandoutcomesofcoronavirus19patientsaretrospectivecohortstudy AT dongilpark theinfluenceofsexoncharacteristicsandoutcomesofcoronavirus19patientsaretrospectivecohortstudy AT dahyunkang theinfluenceofsexoncharacteristicsandoutcomesofcoronavirus19patientsaretrospectivecohortstudy AT yerinju theinfluenceofsexoncharacteristicsandoutcomesofcoronavirus19patientsaretrospectivecohortstudy AT jeongeunlee theinfluenceofsexoncharacteristicsandoutcomesofcoronavirus19patientsaretrospectivecohortstudy AT songilee influenceofsexoncharacteristicsandoutcomesofcoronavirus19patientsaretrospectivecohortstudy AT chaeukchung influenceofsexoncharacteristicsandoutcomesofcoronavirus19patientsaretrospectivecohortstudy AT dongilpark influenceofsexoncharacteristicsandoutcomesofcoronavirus19patientsaretrospectivecohortstudy AT dahyunkang influenceofsexoncharacteristicsandoutcomesofcoronavirus19patientsaretrospectivecohortstudy AT yerinju influenceofsexoncharacteristicsandoutcomesofcoronavirus19patientsaretrospectivecohortstudy AT jeongeunlee influenceofsexoncharacteristicsandoutcomesofcoronavirus19patientsaretrospectivecohortstudy |