Cross‐linked Triblock Peptide Capsules as Potential Oxygen Carriers
Abstract Perfluorodecalin (PFD)‐filled capsules have been studied for over 15 years as artificial oxygen carriers. However, none of these capsules combines good biocompatibility, good mechanical stability and dispersion stability. Here we propose to use synthetic triblock peptides containing a centr...
Main Authors: | , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Wiley-VCH
2024-04-01
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Series: | ChemistryOpen |
Online Access: | https://doi.org/10.1002/open.202300282 |
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author | Huayang Feng Jürgen Linders Miriam Cantore Jonas Fabrizi Annika Kirsten Sascha Myszkowska Eva Hillen Florian Uteschil Sebastian Buchholz Andrea Hermsen Maria Davila Garvin Katja Bettina Ferenz Christian Mayer |
author_facet | Huayang Feng Jürgen Linders Miriam Cantore Jonas Fabrizi Annika Kirsten Sascha Myszkowska Eva Hillen Florian Uteschil Sebastian Buchholz Andrea Hermsen Maria Davila Garvin Katja Bettina Ferenz Christian Mayer |
author_sort | Huayang Feng |
collection | DOAJ |
description | Abstract Perfluorodecalin (PFD)‐filled capsules have been studied for over 15 years as artificial oxygen carriers. However, none of these capsules combines good biocompatibility, good mechanical stability and dispersion stability. Here we propose to use synthetic triblock peptides containing a central block of cysteine units as a cross‐linking shell material for capsules with both good biocompatibility and stability. Together with outer aspartate units and inner phenylalanine units, the resulting amphiphilic triblock peptides can encapsulate PFD efficiently to prepare capsules with a suitable diameter, a certain mechanical strength, a large diffusion constant, fast gas exchange rates, and little cytotoxicity. Given the above advantages, these PFD‐filled peptide capsules are very promising as potential artificial oxygen carriers. |
first_indexed | 2024-04-24T11:36:33Z |
format | Article |
id | doaj.art-b19fb7f09c1b4beaa729e21b6ea79a62 |
institution | Directory Open Access Journal |
issn | 2191-1363 |
language | English |
last_indexed | 2024-04-24T11:36:33Z |
publishDate | 2024-04-01 |
publisher | Wiley-VCH |
record_format | Article |
series | ChemistryOpen |
spelling | doaj.art-b19fb7f09c1b4beaa729e21b6ea79a622024-04-10T05:08:45ZengWiley-VCHChemistryOpen2191-13632024-04-01134n/an/a10.1002/open.202300282Cross‐linked Triblock Peptide Capsules as Potential Oxygen CarriersHuayang Feng0Jürgen Linders1Miriam Cantore2Jonas Fabrizi3Annika Kirsten4Sascha Myszkowska5Eva Hillen6Florian Uteschil7Sebastian Buchholz8Andrea Hermsen9Maria Davila Garvin10Katja Bettina Ferenz11Christian Mayer12Institute for Physical Chemistry CeNIDE University of Duisburg-Essen 45141 Essen GermanyInstitute for Physical Chemistry CeNIDE University of Duisburg-Essen 45141 Essen GermanyInstitute of Physiology University Hospital Essen CeNIDE University of Duisburg-Essen 45147 Essen GermanyInstitute of Inorganic Chemistry and Structural Chemistry Heinrich-Heine-Universität Düsseldorf 40225 Düsseldorf GermanyInstitute for Physical Chemistry CeNIDE University of Duisburg-Essen 45141 Essen GermanyInstitute for Physical Chemistry CeNIDE University of Duisburg-Essen 45141 Essen GermanyInstitute of Physiology University Hospital Essen CeNIDE University of Duisburg-Essen 45147 Essen GermanyApplied Analytical Chemistry University of Duisburg-Essen 45141 Essen GermanyInstitute for Technical Chemistry University of Duisburg-Essen 45141 Essen GermanyInstitute for Physical Chemistry CeNIDE University of Duisburg-Essen 45141 Essen GermanyInstitute for Physical Chemistry CeNIDE University of Duisburg-Essen 45141 Essen GermanyInstitute of Physiology University Hospital Essen CeNIDE University of Duisburg-Essen 45147 Essen GermanyInstitute for Physical Chemistry CeNIDE University of Duisburg-Essen 45141 Essen GermanyAbstract Perfluorodecalin (PFD)‐filled capsules have been studied for over 15 years as artificial oxygen carriers. However, none of these capsules combines good biocompatibility, good mechanical stability and dispersion stability. Here we propose to use synthetic triblock peptides containing a central block of cysteine units as a cross‐linking shell material for capsules with both good biocompatibility and stability. Together with outer aspartate units and inner phenylalanine units, the resulting amphiphilic triblock peptides can encapsulate PFD efficiently to prepare capsules with a suitable diameter, a certain mechanical strength, a large diffusion constant, fast gas exchange rates, and little cytotoxicity. Given the above advantages, these PFD‐filled peptide capsules are very promising as potential artificial oxygen carriers.https://doi.org/10.1002/open.202300282 |
spellingShingle | Huayang Feng Jürgen Linders Miriam Cantore Jonas Fabrizi Annika Kirsten Sascha Myszkowska Eva Hillen Florian Uteschil Sebastian Buchholz Andrea Hermsen Maria Davila Garvin Katja Bettina Ferenz Christian Mayer Cross‐linked Triblock Peptide Capsules as Potential Oxygen Carriers ChemistryOpen |
title | Cross‐linked Triblock Peptide Capsules as Potential Oxygen Carriers |
title_full | Cross‐linked Triblock Peptide Capsules as Potential Oxygen Carriers |
title_fullStr | Cross‐linked Triblock Peptide Capsules as Potential Oxygen Carriers |
title_full_unstemmed | Cross‐linked Triblock Peptide Capsules as Potential Oxygen Carriers |
title_short | Cross‐linked Triblock Peptide Capsules as Potential Oxygen Carriers |
title_sort | cross linked triblock peptide capsules as potential oxygen carriers |
url | https://doi.org/10.1002/open.202300282 |
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