Modulation of Mismatch Repair and the SOCS1/p53 Axis by microRNA-155 in the Colon of Patients with Primary Sclerosing Cholangitis

Modulation of Mismatch Repair and the SOCS1/p53 Axis by microRNA-155 in the Colon of Patients with Primary Sclerosing Cholangitis

Deficient mismatch repair (MMR) proteins may lead to DNA damage and microsatellite instability. Primary sclerosing cholangitis (PSC) is a risk factor for colitis-associated colon cancer. MiR-155 is suggested to act as a key regulating node, linking inflammation and tumorigenesis. However, its involv...

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Bibliographic Details
Main Authors: Monika Adamowicz, Iga Stukan, Piotr Milkiewicz, Andrzej Bialek, Malgorzata Milkiewicz, Agnieszka Kempinska-Podhorodecka
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
miR-155
biomarker
microsatellite instability
inflammation
primary sclerosing cholangitis
colorectal cancer
Online Access:https://www.mdpi.com/1422-0067/23/9/4905

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