A Case of Hepatic Malignant Solitary Fibrous Tumor: A Case Report and Review of the Literature
A 73-year-old man with a history of atrial myxoma and basal cell carcinoma presented with unexplained fever. Contrast-enhanced CT abdomen showed a large left hepatic lobe mass with early enhancement and delayed venous washout, concerning for hepatocellular carcinoma. Fine needle aspiration showed nu...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
|
| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2023/2271690 |
| _version_ | 1826824208835936256 |
|---|---|
| author | Zhiyan Fu Evita B. Henderson-Jackson Barbara A. Centeno Gregory Y. Lauwers Mihaela Druta Daniel A. Anaya Yukihiro Nakanishi |
| author_facet | Zhiyan Fu Evita B. Henderson-Jackson Barbara A. Centeno Gregory Y. Lauwers Mihaela Druta Daniel A. Anaya Yukihiro Nakanishi |
| author_sort | Zhiyan Fu |
| collection | DOAJ |
| description | A 73-year-old man with a history of atrial myxoma and basal cell carcinoma presented with unexplained fever. Contrast-enhanced CT abdomen showed a large left hepatic lobe mass with early enhancement and delayed venous washout, concerning for hepatocellular carcinoma. Fine needle aspiration showed numerous spindle cells with malignant nuclear features, suggestive of malignant spindle cell neoplasm. The patient underwent left hepatectomy. The surgical specimen showed a well-circumscribe solid mass (14.6×13.0×10.0 cm) with necrosis. Histopathological examination revealed a proliferation of spindle tumor cells with characteristic staghorn-shaped blood vessels, frequent mitoses, and necrosis. The tumor cells showed strong and diffuse expression of CD34 and STAT6, confirming the diagnosis of malignant solitary fibrous tumor. Solitary fibrous tumor is a rare fibroblastic tumor characterized by a staghorn vasculature and NAB2-STAT6 gene rearrangement. Solitary fibrous tumor of the liver is a rare occurrence. Although most solitary fibrous tumors behave in a benign fashion, solitary fibrous tumors might act aggressively. This case is unique in that it demonstrates an excellent correlation between radiologic, macroscopic, and microscopic features which can contribute to the improvement of radiologic and pathologic diagnostic accuracy. |
| first_indexed | 2024-04-10T09:26:52Z |
| format | Article |
| id | doaj.art-b1a1ea661588408ebd9416636892a6c8 |
| institution | Directory Open Access Journal |
| issn | 2090-679X |
| language | English |
| last_indexed | 2025-02-16T07:36:03Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj.art-b1a1ea661588408ebd9416636892a6c82025-02-03T06:04:52ZengWileyCase Reports in Pathology2090-679X2023-01-01202310.1155/2023/2271690A Case of Hepatic Malignant Solitary Fibrous Tumor: A Case Report and Review of the LiteratureZhiyan Fu0Evita B. Henderson-Jackson1Barbara A. Centeno2Gregory Y. Lauwers3Mihaela Druta4Daniel A. Anaya5Yukihiro Nakanishi6Department of PathologyDepartment of PathologyDepartment of PathologyDepartment of PathologyDepartment of Medical OncologyDepartment of Gastrointestinal OncologyDepartment of PathologyA 73-year-old man with a history of atrial myxoma and basal cell carcinoma presented with unexplained fever. Contrast-enhanced CT abdomen showed a large left hepatic lobe mass with early enhancement and delayed venous washout, concerning for hepatocellular carcinoma. Fine needle aspiration showed numerous spindle cells with malignant nuclear features, suggestive of malignant spindle cell neoplasm. The patient underwent left hepatectomy. The surgical specimen showed a well-circumscribe solid mass (14.6×13.0×10.0 cm) with necrosis. Histopathological examination revealed a proliferation of spindle tumor cells with characteristic staghorn-shaped blood vessels, frequent mitoses, and necrosis. The tumor cells showed strong and diffuse expression of CD34 and STAT6, confirming the diagnosis of malignant solitary fibrous tumor. Solitary fibrous tumor is a rare fibroblastic tumor characterized by a staghorn vasculature and NAB2-STAT6 gene rearrangement. Solitary fibrous tumor of the liver is a rare occurrence. Although most solitary fibrous tumors behave in a benign fashion, solitary fibrous tumors might act aggressively. This case is unique in that it demonstrates an excellent correlation between radiologic, macroscopic, and microscopic features which can contribute to the improvement of radiologic and pathologic diagnostic accuracy.http://dx.doi.org/10.1155/2023/2271690 |
| spellingShingle | Zhiyan Fu Evita B. Henderson-Jackson Barbara A. Centeno Gregory Y. Lauwers Mihaela Druta Daniel A. Anaya Yukihiro Nakanishi A Case of Hepatic Malignant Solitary Fibrous Tumor: A Case Report and Review of the Literature Case Reports in Pathology |
| title | A Case of Hepatic Malignant Solitary Fibrous Tumor: A Case Report and Review of the Literature |
| title_full | A Case of Hepatic Malignant Solitary Fibrous Tumor: A Case Report and Review of the Literature |
| title_fullStr | A Case of Hepatic Malignant Solitary Fibrous Tumor: A Case Report and Review of the Literature |
| title_full_unstemmed | A Case of Hepatic Malignant Solitary Fibrous Tumor: A Case Report and Review of the Literature |
| title_short | A Case of Hepatic Malignant Solitary Fibrous Tumor: A Case Report and Review of the Literature |
| title_sort | case of hepatic malignant solitary fibrous tumor a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2023/2271690 |
| work_keys_str_mv | AT zhiyanfu acaseofhepaticmalignantsolitaryfibroustumoracasereportandreviewoftheliterature AT evitabhendersonjackson acaseofhepaticmalignantsolitaryfibroustumoracasereportandreviewoftheliterature AT barbaraacenteno acaseofhepaticmalignantsolitaryfibroustumoracasereportandreviewoftheliterature AT gregoryylauwers acaseofhepaticmalignantsolitaryfibroustumoracasereportandreviewoftheliterature AT mihaeladruta acaseofhepaticmalignantsolitaryfibroustumoracasereportandreviewoftheliterature AT danielaanaya acaseofhepaticmalignantsolitaryfibroustumoracasereportandreviewoftheliterature AT yukihironakanishi acaseofhepaticmalignantsolitaryfibroustumoracasereportandreviewoftheliterature AT zhiyanfu caseofhepaticmalignantsolitaryfibroustumoracasereportandreviewoftheliterature AT evitabhendersonjackson caseofhepaticmalignantsolitaryfibroustumoracasereportandreviewoftheliterature AT barbaraacenteno caseofhepaticmalignantsolitaryfibroustumoracasereportandreviewoftheliterature AT gregoryylauwers caseofhepaticmalignantsolitaryfibroustumoracasereportandreviewoftheliterature AT mihaeladruta caseofhepaticmalignantsolitaryfibroustumoracasereportandreviewoftheliterature AT danielaanaya caseofhepaticmalignantsolitaryfibroustumoracasereportandreviewoftheliterature AT yukihironakanishi caseofhepaticmalignantsolitaryfibroustumoracasereportandreviewoftheliterature |