SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS
<strong>Abstract. </strong>Salmon soft roe DNA influence on healthy donors blood cells secretion of early hemopoietic factors (IL-3, GM-CSF, TNFα) as well as biologically active substance influence on cytokine balance of Тh1 and Тh2 responses (IFNγ, IL-10) in vitro was studied. It is est...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | http://mimmun.ru/index.php/mimmun/article/view/654 |
| _version_ | 1797703943731544064 |
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| author | L. N. Fedjanina |
| author_facet | L. N. Fedjanina |
| author_sort | L. N. Fedjanina |
| collection | DOAJ |
| description | <strong>Abstract. </strong>Salmon soft roe DNA influence on healthy donors blood cells secretion of early hemopoietic factors (IL-3, GM-CSF, TNFα) as well as biologically active substance influence on cytokine balance of Тh1 and Тh2 responses (IFNγ, IL-10) in vitro was studied. It is established, that DNA has modulatory effect on secretion of all investigated cytokines - IL-3, GM-CSF, TNFα, INFγ and IL-10 by blood cells of healthy donors, increases their initially low concentration, reduces initially high and does not have essential influence at an average level of their secretion. Under action of DNA IFNγ level (stimulation index=3,3) increases more significantly than IL-10 level (stimulation index =1,9). Thus, salmon soft roe DNA possesses immunomodulatory properties. |
| first_indexed | 2024-03-12T05:11:55Z |
| format | Article |
| id | doaj.art-b1a2d7e3981f4e239841c9c20ac0890e |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-03-12T05:11:55Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-b1a2d7e3981f4e239841c9c20ac0890e2023-09-03T08:29:23ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0175–661761910.15789/1563-0625-2005-5–6-617-619651SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORSL. N. Fedjanina0Научно–исследовательский институт эпидемиологии и микробиологии СО РАМН, г. Владивосток<strong>Abstract. </strong>Salmon soft roe DNA influence on healthy donors blood cells secretion of early hemopoietic factors (IL-3, GM-CSF, TNFα) as well as biologically active substance influence on cytokine balance of Тh1 and Тh2 responses (IFNγ, IL-10) in vitro was studied. It is established, that DNA has modulatory effect on secretion of all investigated cytokines - IL-3, GM-CSF, TNFα, INFγ and IL-10 by blood cells of healthy donors, increases their initially low concentration, reduces initially high and does not have essential influence at an average level of their secretion. Under action of DNA IFNγ level (stimulation index=3,3) increases more significantly than IL-10 level (stimulation index =1,9). Thus, salmon soft roe DNA possesses immunomodulatory properties.http://mimmun.ru/index.php/mimmun/article/view/654salmon soft roe DNAcytokineshealthy donorslymphocyteslymphocytes subpopulations |
| spellingShingle | L. N. Fedjanina SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS Медицинская иммунология salmon soft roe DNA cytokines healthy donors lymphocytes lymphocytes subpopulations |
| title | SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS |
| title_full | SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS |
| title_fullStr | SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS |
| title_full_unstemmed | SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS |
| title_short | SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS |
| title_sort | salmon soft roe dna on blood cells secretion of cytokines in healthy donors |
| topic | salmon soft roe DNA cytokines healthy donors lymphocytes lymphocytes subpopulations |
| url | http://mimmun.ru/index.php/mimmun/article/view/654 |
| work_keys_str_mv | AT lnfedjanina salmonsoftroednaonbloodcellssecretionofcytokinesinhealthydonors |