Two HIV-1 variants resistant to small molecule CCR5 inhibitors differ in how they use CCR5 for entry.

Two HIV-1 variants resistant to small molecule CCR5 inhibitors differ in how they use CCR5 for entry.

HIV-1 variants resistant to small molecule CCR5 inhibitors recognize the inhibitor-CCR5 complex, while also interacting with free CCR5. The most common genetic route to resistance involves sequence changes in the gp120 V3 region, a pathway followed when the primary isolate CC1/85 was cultured with t...

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Bibliographic Details
Main Authors: Reem Berro, Rogier W Sanders, Min Lu, Per J Klasse, John P Moore
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2718843?pdf=render

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