Acute-on-Chronic Liver Failure in Cirrhosis
Acute-on-chronic liver failure (ACLF) is a syndrome that develops in patients with acutely decompensated chronic liver disease. It is characterised by high 28-day mortality, the presence of one or more organ failures (OFs) and a variable but severe grade of systemic inflammation. Despite the peculia...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/10/19/4406 |
| _version_ | 1797516221509271552 |
|---|---|
| author | Carmine Gambino Salvatore Piano Paolo Angeli |
| author_facet | Carmine Gambino Salvatore Piano Paolo Angeli |
| author_sort | Carmine Gambino |
| collection | DOAJ |
| description | Acute-on-chronic liver failure (ACLF) is a syndrome that develops in patients with acutely decompensated chronic liver disease. It is characterised by high 28-day mortality, the presence of one or more organ failures (OFs) and a variable but severe grade of systemic inflammation. Despite the peculiarity of each one, every definition proposed for ACLF recognizes it as a proper clinical entity. In this paper, we provide an overview of the diagnostic criteria proposed by the different scientific societies and the clinical characteristics of the syndrome. Established and experimental treatments are also described. Among the former, the most relevant are directed to support organ failures, treat precipitating factors and carry out early assessment for liver transplantation (LT). Further studies are needed to better clarify pathophysiology of the syndrome and discover new therapies. |
| first_indexed | 2024-03-10T06:58:13Z |
| format | Article |
| id | doaj.art-b1a4837e2bf34c68ac1151ea1cd84813 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T06:58:13Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-b1a4837e2bf34c68ac1151ea1cd848132023-11-22T16:18:59ZengMDPI AGJournal of Clinical Medicine2077-03832021-09-011019440610.3390/jcm10194406Acute-on-Chronic Liver Failure in CirrhosisCarmine Gambino0Salvatore Piano1Paolo Angeli2Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine (DIMED), University of Padova, 35128 Padova, ItalyUnit of Internal Medicine and Hepatology (UIMH), Department of Medicine (DIMED), University of Padova, 35128 Padova, ItalyUnit of Internal Medicine and Hepatology (UIMH), Department of Medicine (DIMED), University of Padova, 35128 Padova, ItalyAcute-on-chronic liver failure (ACLF) is a syndrome that develops in patients with acutely decompensated chronic liver disease. It is characterised by high 28-day mortality, the presence of one or more organ failures (OFs) and a variable but severe grade of systemic inflammation. Despite the peculiarity of each one, every definition proposed for ACLF recognizes it as a proper clinical entity. In this paper, we provide an overview of the diagnostic criteria proposed by the different scientific societies and the clinical characteristics of the syndrome. Established and experimental treatments are also described. Among the former, the most relevant are directed to support organ failures, treat precipitating factors and carry out early assessment for liver transplantation (LT). Further studies are needed to better clarify pathophysiology of the syndrome and discover new therapies.https://www.mdpi.com/2077-0383/10/19/4406acute-on-chronic liver failure (ACLF)cirrhosisliver transplantation (LT) |
| spellingShingle | Carmine Gambino Salvatore Piano Paolo Angeli Acute-on-Chronic Liver Failure in Cirrhosis Journal of Clinical Medicine acute-on-chronic liver failure (ACLF) cirrhosis liver transplantation (LT) |
| title | Acute-on-Chronic Liver Failure in Cirrhosis |
| title_full | Acute-on-Chronic Liver Failure in Cirrhosis |
| title_fullStr | Acute-on-Chronic Liver Failure in Cirrhosis |
| title_full_unstemmed | Acute-on-Chronic Liver Failure in Cirrhosis |
| title_short | Acute-on-Chronic Liver Failure in Cirrhosis |
| title_sort | acute on chronic liver failure in cirrhosis |
| topic | acute-on-chronic liver failure (ACLF) cirrhosis liver transplantation (LT) |
| url | https://www.mdpi.com/2077-0383/10/19/4406 |
| work_keys_str_mv | AT carminegambino acuteonchronicliverfailureincirrhosis AT salvatorepiano acuteonchronicliverfailureincirrhosis AT paoloangeli acuteonchronicliverfailureincirrhosis |