Piperine reduces hair oiliness by inhibiting adipogenesis of hair stem cells
Abstract Piperine, an alkaloid compound in black pepper (Piper nigrum), has beneficial bioactivities. Specifically, piperine inhibits adipogenesis in 3T3-L1 cells by suppressing the transcriptional activity of PPARγ. Control of hair oiliness, which is related to adipogenic regulation, is important t...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2024-04-01
|
| Series: | Applied Biological Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13765-024-00889-4 |
| _version_ | 1827291406518976512 |
|---|---|
| author | Minyoung Im Nackhyoung Kim Ui-Hyun Park Hyeon Ho Heo Soo-Jong Um |
| author_facet | Minyoung Im Nackhyoung Kim Ui-Hyun Park Hyeon Ho Heo Soo-Jong Um |
| author_sort | Minyoung Im |
| collection | DOAJ |
| description | Abstract Piperine, an alkaloid compound in black pepper (Piper nigrum), has beneficial bioactivities. Specifically, piperine inhibits adipogenesis in 3T3-L1 cells by suppressing the transcriptional activity of PPARγ. Control of hair oiliness, which is related to adipogenic regulation, is important to prevent hair loss. Excessive sebum from the sebaceous gland (SG) can cause acne, folliculitis, or irritated skin by clogging pores. To investigate the in vivo function of piperine in SG, we used mice fed a high-fat diet (HFD). The HFD increased the size and Oil Red O (ORO) staining intensity of SG, which were significantly reduced by piperine. The HFD also upregulated the expression of sebocyte-associated genes, including PPARγ target genes, an effect reversed by piperine. In CD34/CD49f double-positive hair follicle bulge stem cells isolated from mouse vibrissae, piperine inhibited cellular adipogenesis, likely via transcriptional repression of related genes. Furthermore, piperine reduced the thickness of subcutaneous fat. In human dermal papilla cells, piperine inhibited cellular adipogenesis, as shown by the reduction in ORO staining and the downregulation of PPARγ target genes. In conclusion, piperine can be used to reduce hair greasiness by suppressing adipogenesis in hair stem cells. |
| first_indexed | 2024-04-24T12:36:28Z |
| format | Article |
| id | doaj.art-b1a4f2dcbbe548d58590a4392d03736d |
| institution | Directory Open Access Journal |
| issn | 2468-0842 |
| language | English |
| last_indexed | 2024-04-24T12:36:28Z |
| publishDate | 2024-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Applied Biological Chemistry |
| spelling | doaj.art-b1a4f2dcbbe548d58590a4392d03736d2024-04-07T11:27:59ZengSpringerOpenApplied Biological Chemistry2468-08422024-04-0167111010.1186/s13765-024-00889-4Piperine reduces hair oiliness by inhibiting adipogenesis of hair stem cellsMinyoung Im0Nackhyoung Kim1Ui-Hyun Park2Hyeon Ho Heo3Soo-Jong Um4Department of Integrative Bioscience and Biotechnology, Sejong UniversityDepartment of Integrative Bioscience and Biotechnology, Sejong UniversityDepartment of Integrative Bioscience and Biotechnology, Sejong UniversityDepartment of Integrative Bioscience and Biotechnology, Sejong UniversityDepartment of Integrative Bioscience and Biotechnology, Sejong UniversityAbstract Piperine, an alkaloid compound in black pepper (Piper nigrum), has beneficial bioactivities. Specifically, piperine inhibits adipogenesis in 3T3-L1 cells by suppressing the transcriptional activity of PPARγ. Control of hair oiliness, which is related to adipogenic regulation, is important to prevent hair loss. Excessive sebum from the sebaceous gland (SG) can cause acne, folliculitis, or irritated skin by clogging pores. To investigate the in vivo function of piperine in SG, we used mice fed a high-fat diet (HFD). The HFD increased the size and Oil Red O (ORO) staining intensity of SG, which were significantly reduced by piperine. The HFD also upregulated the expression of sebocyte-associated genes, including PPARγ target genes, an effect reversed by piperine. In CD34/CD49f double-positive hair follicle bulge stem cells isolated from mouse vibrissae, piperine inhibited cellular adipogenesis, likely via transcriptional repression of related genes. Furthermore, piperine reduced the thickness of subcutaneous fat. In human dermal papilla cells, piperine inhibited cellular adipogenesis, as shown by the reduction in ORO staining and the downregulation of PPARγ target genes. In conclusion, piperine can be used to reduce hair greasiness by suppressing adipogenesis in hair stem cells.https://doi.org/10.1186/s13765-024-00889-4Black pepper (Piper nigrum)PiperineAdipogenesisBulge stem cellsHigh-fat dietDermal papilla cells |
| spellingShingle | Minyoung Im Nackhyoung Kim Ui-Hyun Park Hyeon Ho Heo Soo-Jong Um Piperine reduces hair oiliness by inhibiting adipogenesis of hair stem cells Applied Biological Chemistry Black pepper (Piper nigrum) Piperine Adipogenesis Bulge stem cells High-fat diet Dermal papilla cells |
| title | Piperine reduces hair oiliness by inhibiting adipogenesis of hair stem cells |
| title_full | Piperine reduces hair oiliness by inhibiting adipogenesis of hair stem cells |
| title_fullStr | Piperine reduces hair oiliness by inhibiting adipogenesis of hair stem cells |
| title_full_unstemmed | Piperine reduces hair oiliness by inhibiting adipogenesis of hair stem cells |
| title_short | Piperine reduces hair oiliness by inhibiting adipogenesis of hair stem cells |
| title_sort | piperine reduces hair oiliness by inhibiting adipogenesis of hair stem cells |
| topic | Black pepper (Piper nigrum) Piperine Adipogenesis Bulge stem cells High-fat diet Dermal papilla cells |
| url | https://doi.org/10.1186/s13765-024-00889-4 |
| work_keys_str_mv | AT minyoungim piperinereduceshairoilinessbyinhibitingadipogenesisofhairstemcells AT nackhyoungkim piperinereduceshairoilinessbyinhibitingadipogenesisofhairstemcells AT uihyunpark piperinereduceshairoilinessbyinhibitingadipogenesisofhairstemcells AT hyeonhoheo piperinereduceshairoilinessbyinhibitingadipogenesisofhairstemcells AT soojongum piperinereduceshairoilinessbyinhibitingadipogenesisofhairstemcells |