SIRT2 inhibition by AGK2 enhances mycobacteria-specific stem cell memory responses by modulating beta-catenin and glycolysis

SIRT2 inhibition by AGK2 enhances mycobacteria-specific stem cell memory responses by modulating beta-catenin and glycolysis

Summary: Bacille Calmette-Guerin (BCG) generates limited long-lasting adaptive memory responses leading to short-lived protection against adult pulmonary tuberculosis (TB). Here, we show that host sirtuin 2 (SIRT2) inhibition by AGK2 significantly enhances the BCG vaccine efficacy during primary inf...

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Bibliographic Details
Main Authors: Ashima Bhaskar, Isha Pahuja, Kriti Negi, Akanksha Verma, Antara Ghoshal, Babu Mathew, Gaurav Tripathi, Jaswinder Singh Maras, Shivam Chaturvedi, Ved Prakash Dwivedi
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:iScience
Subjects:
Immunology
Bacteriology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223007216

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