A low-cost recombinant glycoconjugate vaccine confers immunogenicity and protection against enterotoxigenic Escherichia coli infections in mice

A low-cost recombinant glycoconjugate vaccine confers immunogenicity and protection against enterotoxigenic Escherichia coli infections in mice

Enterotoxigenic Escherichia coli (ETEC) is the primary etiologic agent of traveler’s diarrhea and a major cause of diarrheal disease and death worldwide, especially in infants and young children. Despite significant efforts over the past several decades, an affordable vaccine that appreciably decrea...

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Bibliographic Details
Main Authors: Asher J. Williams, Katherine F. Warfel, Primit Desai, Jie Li, Jen-Jie Lee, Derek A. Wong, Phuong M. Nguyen, Yufan Qin, Sarah E. Sobol, Michael C. Jewett, Yung-Fu Chang, Matthew P. DeLisa
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
synthetic glycobiology
cell-free (CF) protein synthesis
bacterial protein expression
conjugate vaccine
protein glycan coupling technology
protein glycosylation
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1085887/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1085887/full

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