New Insights on the Role of pentraxin-3 in Allergic Asthma
Pentraxins are soluble pattern recognition receptors that play a major role in regulating innate immune responses. Through their interaction with complement components, Fcγ receptors, and different microbial moieties, Pentraxins cause an amplification of the inflammatory response. Pentraxin-3 is of...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-06-01
|
| Series: | Frontiers in Allergy |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/falgy.2021.678023/full |
| _version_ | 1824019683236380672 |
|---|---|
| author | Latifa Koussih Latifa Koussih Samira Atoui Omar Tliba Abdelilah S. Gounni |
| author_facet | Latifa Koussih Latifa Koussih Samira Atoui Omar Tliba Abdelilah S. Gounni |
| author_sort | Latifa Koussih |
| collection | DOAJ |
| description | Pentraxins are soluble pattern recognition receptors that play a major role in regulating innate immune responses. Through their interaction with complement components, Fcγ receptors, and different microbial moieties, Pentraxins cause an amplification of the inflammatory response. Pentraxin-3 is of particular interest since it was identified as a biomarker for several immune-pathological diseases. In allergic asthma, pentraxin-3 is produced by immune and structural cells and is up-regulated by pro-asthmatic cytokines such as TNFα and IL-1β. Strikingly, some recent experimental evidence demonstrated a protective role of pentraxin-3 in chronic airway inflammatory diseases such as allergic asthma. Indeed, reduced pentraxin-3 levels have been associated with neutrophilic inflammation, Th17 immune response, insensitivity to standard therapeutics and a severe form of the disease. In this review, we will summarize the current knowledge of the role of pentraxin-3 in innate immune response and discuss the protective role of pentraxin-3 in allergic asthma. |
| first_indexed | 2024-12-19T01:22:51Z |
| format | Article |
| id | doaj.art-b1a78f6e012249b9ad7ccb857e32b571 |
| institution | Directory Open Access Journal |
| issn | 2673-6101 |
| language | English |
| last_indexed | 2024-12-19T01:22:51Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Allergy |
| spelling | doaj.art-b1a78f6e012249b9ad7ccb857e32b5712022-12-21T20:42:21ZengFrontiers Media S.A.Frontiers in Allergy2673-61012021-06-01210.3389/falgy.2021.678023678023New Insights on the Role of pentraxin-3 in Allergic AsthmaLatifa Koussih0Latifa Koussih1Samira Atoui2Omar Tliba3Abdelilah S. Gounni4Department of Immunology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, CanadaDepartment des Sciences Experimentales, Universite de Saint-Boniface, Winnipeg, MB, CanadaDepartment of Immunology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, CanadaDepartment of Biomedical Sciences, College of Veterinary Medicine, Long Island University, Brookville, NY, United StatesDepartment of Immunology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, CanadaPentraxins are soluble pattern recognition receptors that play a major role in regulating innate immune responses. Through their interaction with complement components, Fcγ receptors, and different microbial moieties, Pentraxins cause an amplification of the inflammatory response. Pentraxin-3 is of particular interest since it was identified as a biomarker for several immune-pathological diseases. In allergic asthma, pentraxin-3 is produced by immune and structural cells and is up-regulated by pro-asthmatic cytokines such as TNFα and IL-1β. Strikingly, some recent experimental evidence demonstrated a protective role of pentraxin-3 in chronic airway inflammatory diseases such as allergic asthma. Indeed, reduced pentraxin-3 levels have been associated with neutrophilic inflammation, Th17 immune response, insensitivity to standard therapeutics and a severe form of the disease. In this review, we will summarize the current knowledge of the role of pentraxin-3 in innate immune response and discuss the protective role of pentraxin-3 in allergic asthma.https://www.frontiersin.org/articles/10.3389/falgy.2021.678023/fullpentraxin-3allergic asthmainnate immunityairway remodelingglucocorticosteroids |
| spellingShingle | Latifa Koussih Latifa Koussih Samira Atoui Omar Tliba Abdelilah S. Gounni New Insights on the Role of pentraxin-3 in Allergic Asthma Frontiers in Allergy pentraxin-3 allergic asthma innate immunity airway remodeling glucocorticosteroids |
| title | New Insights on the Role of pentraxin-3 in Allergic Asthma |
| title_full | New Insights on the Role of pentraxin-3 in Allergic Asthma |
| title_fullStr | New Insights on the Role of pentraxin-3 in Allergic Asthma |
| title_full_unstemmed | New Insights on the Role of pentraxin-3 in Allergic Asthma |
| title_short | New Insights on the Role of pentraxin-3 in Allergic Asthma |
| title_sort | new insights on the role of pentraxin 3 in allergic asthma |
| topic | pentraxin-3 allergic asthma innate immunity airway remodeling glucocorticosteroids |
| url | https://www.frontiersin.org/articles/10.3389/falgy.2021.678023/full |
| work_keys_str_mv | AT latifakoussih newinsightsontheroleofpentraxin3inallergicasthma AT latifakoussih newinsightsontheroleofpentraxin3inallergicasthma AT samiraatoui newinsightsontheroleofpentraxin3inallergicasthma AT omartliba newinsightsontheroleofpentraxin3inallergicasthma AT abdelilahsgounni newinsightsontheroleofpentraxin3inallergicasthma |