Granulocytic Myeloid-Derived Suppressor Cells (GR-MDSC) in Breast Milk (BM); GR-MDSC Accumulate in Human BM and Modulate T-Cell and Monocyte Function
Nosocomial bacterial infections (NBI) and necrotizing enterocolitis (NEC) are among the main reasons for death in preterm infants. Both are often caused by bacteria coming from the infected infant’s gut and feeding with breast milk (BM) seems beneficial in their pathogenesis. However, mechanisms cau...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2018.01098/full |
| _version_ | 1811259380082933760 |
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| author | Natascha Köstlin Carolin Schoetensack Julian Schwarz Bärbel Spring Alexander Marmé Rangmar Goelz Gerhard Brodbeck Christian F. Poets Christian Gille |
| author_facet | Natascha Köstlin Carolin Schoetensack Julian Schwarz Bärbel Spring Alexander Marmé Rangmar Goelz Gerhard Brodbeck Christian F. Poets Christian Gille |
| author_sort | Natascha Köstlin |
| collection | DOAJ |
| description | Nosocomial bacterial infections (NBI) and necrotizing enterocolitis (NEC) are among the main reasons for death in preterm infants. Both are often caused by bacteria coming from the infected infant’s gut and feeding with breast milk (BM) seems beneficial in their pathogenesis. However, mechanisms causing the protective effect of BM are only incompletely understood. Myeloid-derived suppressor cells (MDSC) are myeloid cells with suppressive activity on other immune cells, recently described to play a role in mediating maternal–fetal tolerance during pregnancy and immune adaptation in newborns. Until now, nothing is known about occurrence and function of MDSC in BM. We analyzed MDSC in BM and peripheral blood of breastfeeding mothers and found that granulocytic MDSC, but not monocytic MDSC, accumulate in BM, exhibit an activated phenotype and increased suppressive activity and modulate TLR-expression on monocytes. Furthermore, we found that the lactotrophic hormones prolactin and oxytocin do not induce MDSC from peripheral blood. This is the first study to describe MDSC with immune-modulatory properties in human BM. Our results point toward a role for MDSC in local immune modulation in the gut possibly protecting infants from NBI and NEC. |
| first_indexed | 2024-04-12T18:29:32Z |
| format | Article |
| id | doaj.art-b1a81c5564df48b0badf225d542fd97a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T18:29:32Z |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b1a81c5564df48b0badf225d542fd97a2022-12-22T03:21:07ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-05-01910.3389/fimmu.2018.01098360800Granulocytic Myeloid-Derived Suppressor Cells (GR-MDSC) in Breast Milk (BM); GR-MDSC Accumulate in Human BM and Modulate T-Cell and Monocyte FunctionNatascha Köstlin0Carolin Schoetensack1Julian Schwarz2Bärbel Spring3Alexander Marmé4Rangmar Goelz5Gerhard Brodbeck6Christian F. Poets7Christian Gille8Department of Neonatology, Tuebingen University Children’s Hospital, Tuebingen, GermanyDepartment of Neonatology, Tuebingen University Children’s Hospital, Tuebingen, GermanyDepartment of Neonatology, Tuebingen University Children’s Hospital, Tuebingen, GermanyDepartment of Neonatology, Tuebingen University Children’s Hospital, Tuebingen, GermanyPrivate Practice in Gynecology and Obstetrics, Tuebingen, GermanyDepartment of Neonatology, Tuebingen University Children’s Hospital, Tuebingen, GermanyDepartment of Hematology, Tuebingen University Children’s Hospital, Tuebingen, GermanyDepartment of Neonatology, Tuebingen University Children’s Hospital, Tuebingen, GermanyDepartment of Neonatology, Tuebingen University Children’s Hospital, Tuebingen, GermanyNosocomial bacterial infections (NBI) and necrotizing enterocolitis (NEC) are among the main reasons for death in preterm infants. Both are often caused by bacteria coming from the infected infant’s gut and feeding with breast milk (BM) seems beneficial in their pathogenesis. However, mechanisms causing the protective effect of BM are only incompletely understood. Myeloid-derived suppressor cells (MDSC) are myeloid cells with suppressive activity on other immune cells, recently described to play a role in mediating maternal–fetal tolerance during pregnancy and immune adaptation in newborns. Until now, nothing is known about occurrence and function of MDSC in BM. We analyzed MDSC in BM and peripheral blood of breastfeeding mothers and found that granulocytic MDSC, but not monocytic MDSC, accumulate in BM, exhibit an activated phenotype and increased suppressive activity and modulate TLR-expression on monocytes. Furthermore, we found that the lactotrophic hormones prolactin and oxytocin do not induce MDSC from peripheral blood. This is the first study to describe MDSC with immune-modulatory properties in human BM. Our results point toward a role for MDSC in local immune modulation in the gut possibly protecting infants from NBI and NEC.http://journal.frontiersin.org/article/10.3389/fimmu.2018.01098/fullmyeloid-derived suppressor cellbreast milkTLR4oxytocinprolactin |
| spellingShingle | Natascha Köstlin Carolin Schoetensack Julian Schwarz Bärbel Spring Alexander Marmé Rangmar Goelz Gerhard Brodbeck Christian F. Poets Christian Gille Granulocytic Myeloid-Derived Suppressor Cells (GR-MDSC) in Breast Milk (BM); GR-MDSC Accumulate in Human BM and Modulate T-Cell and Monocyte Function Frontiers in Immunology myeloid-derived suppressor cell breast milk TLR4 oxytocin prolactin |
| title | Granulocytic Myeloid-Derived Suppressor Cells (GR-MDSC) in Breast Milk (BM); GR-MDSC Accumulate in Human BM and Modulate T-Cell and Monocyte Function |
| title_full | Granulocytic Myeloid-Derived Suppressor Cells (GR-MDSC) in Breast Milk (BM); GR-MDSC Accumulate in Human BM and Modulate T-Cell and Monocyte Function |
| title_fullStr | Granulocytic Myeloid-Derived Suppressor Cells (GR-MDSC) in Breast Milk (BM); GR-MDSC Accumulate in Human BM and Modulate T-Cell and Monocyte Function |
| title_full_unstemmed | Granulocytic Myeloid-Derived Suppressor Cells (GR-MDSC) in Breast Milk (BM); GR-MDSC Accumulate in Human BM and Modulate T-Cell and Monocyte Function |
| title_short | Granulocytic Myeloid-Derived Suppressor Cells (GR-MDSC) in Breast Milk (BM); GR-MDSC Accumulate in Human BM and Modulate T-Cell and Monocyte Function |
| title_sort | granulocytic myeloid derived suppressor cells gr mdsc in breast milk bm gr mdsc accumulate in human bm and modulate t cell and monocyte function |
| topic | myeloid-derived suppressor cell breast milk TLR4 oxytocin prolactin |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2018.01098/full |
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