The effects of ethanolic extract of the leaves of Erythroxylum mucronatum (Benth.) (Erythroxylaceae) on strength and muscle performance of resistance trained rats
Background: The Erythroxylaceae family is known worldwide for its species that contain compounds with a marked positive effect on physical performance, such as ephedrine and coca. E. mucronatum is a species of this family found in several parts of South America, mainly in the northern and northeaste...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Phytomedicine Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031322000161 |
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| author | Elizabete Silva-Filha Nathanielly L. Silva Fabrício N. Macedo Luiz Ícaro C. Santos Andreza S. Santos Márcio R.V. Santos Marcelo C. Duarte Cícero F.S. Aragão Fernando H.A. Nogueira Adley A.N. Lima Gokhan Zengin Henrique Douglas Melo Coutinho Dulce M. Schimieguel Jullyana S.S. Quintans Lucindo J. Quintans-Júnior |
| author_facet | Elizabete Silva-Filha Nathanielly L. Silva Fabrício N. Macedo Luiz Ícaro C. Santos Andreza S. Santos Márcio R.V. Santos Marcelo C. Duarte Cícero F.S. Aragão Fernando H.A. Nogueira Adley A.N. Lima Gokhan Zengin Henrique Douglas Melo Coutinho Dulce M. Schimieguel Jullyana S.S. Quintans Lucindo J. Quintans-Júnior |
| author_sort | Elizabete Silva-Filha |
| collection | DOAJ |
| description | Background: The Erythroxylaceae family is known worldwide for its species that contain compounds with a marked positive effect on physical performance, such as ephedrine and coca. E. mucronatum is a species of this family found in several parts of South America, mainly in the northern and northeastern regions of Brazil, used by natives to improve strength and physical performance. Purpose: We set out to investigate, for the first time, in a series of experiments whether the ethanolic extract of E. mucronatum (EEM) had any effect on performance and strength of rats undergoing resistance training. Methods: We promoted a supplementation with EEM and searched it increased strength, muscular endurance and reduced body fat in the rodents. Results: we registered a significant reduction in lipid peroxidation and an increase in superoxide dismutase in the exercised muscles. EEM supplementation did not alter the effect of exercise on blood pressure and heart rate. Additionally, we noticed a significant reduction in two markers of muscle damage, CK and LDH, but no alterations were observed in the levels of ALT and AST. Conclusions: The results showed that EEM was able to improve the physical performance of the rats without any remarkable adverse effects on hemodynamic variables, so it should be further investigated to examine whether it also has potential as an effective dietary supplement in humans to improve performance in resistance exercise cycles. |
| first_indexed | 2024-12-12T21:09:00Z |
| format | Article |
| id | doaj.art-b1aa0e72ce774c08a9d815961580c290 |
| institution | Directory Open Access Journal |
| issn | 2667-0313 |
| language | English |
| last_indexed | 2024-12-12T21:09:00Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj.art-b1aa0e72ce774c08a9d815961580c2902022-12-22T00:11:56ZengElsevierPhytomedicine Plus2667-03132022-05-0122100230The effects of ethanolic extract of the leaves of Erythroxylum mucronatum (Benth.) (Erythroxylaceae) on strength and muscle performance of resistance trained ratsElizabete Silva-Filha0Nathanielly L. Silva1Fabrício N. Macedo2Luiz Ícaro C. Santos3Andreza S. Santos4Márcio R.V. Santos5Marcelo C. Duarte6Cícero F.S. Aragão7Fernando H.A. Nogueira8Adley A.N. Lima9Gokhan Zengin10Henrique Douglas Melo Coutinho11Dulce M. Schimieguel12Jullyana S.S. Quintans13Lucindo J. Quintans-Júnior14Department of Physiology, Laboratory of Neuroscience and Pharmacological Assays (LANEF). Federal University of Sergipe, São Cristóvão, Sergipe, BrazilDepartment of Physiology, Laboratory of Neuroscience and Pharmacological Assays (LANEF). Federal University of Sergipe, São Cristóvão, Sergipe, BrazilDepartment of Physiology, Laboratory of Neuroscience and Pharmacological Assays (LANEF). Federal University of Sergipe, São Cristóvão, Sergipe, BrazilDepartment of Nutrition, Federal University of Sergipe, São Cristóvão, Sergipe, BrazilDepartment of Nutrition, Federal University of Sergipe, São Cristóvão, Sergipe, BrazilDepartment of Physiology, Laboratory of Neuroscience and Pharmacological Assays (LANEF). Federal University of Sergipe, São Cristóvão, Sergipe, BrazilDepartment of Pharmacy, Federal University of Sergipe, São Cristóvão, Sergipe, BrazilDepartment of Pharmacy, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, BrazilDepartment of Pharmacy, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, BrazilDepartment of Pharmacy, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, BrazilDepartment of Biology, Science Faculty, Selcuk University, Konya, TurkeyDepartment of Biological Chemistry, Regional University of Cariri, Crato, Ceará, Brazil; Corresponding author.Department of Pharmacy, Federal University of Sergipe, São Cristóvão, Sergipe, BrazilDepartment of Physiology, Laboratory of Neuroscience and Pharmacological Assays (LANEF). Federal University of Sergipe, São Cristóvão, Sergipe, BrazilDepartment of Physiology, Laboratory of Neuroscience and Pharmacological Assays (LANEF). Federal University of Sergipe, São Cristóvão, Sergipe, Brazil; Corresponding author at: Rua Coronel Antônio Luíz, 1161 - Pimenta, Crato - CE, 63105-010.Background: The Erythroxylaceae family is known worldwide for its species that contain compounds with a marked positive effect on physical performance, such as ephedrine and coca. E. mucronatum is a species of this family found in several parts of South America, mainly in the northern and northeastern regions of Brazil, used by natives to improve strength and physical performance. Purpose: We set out to investigate, for the first time, in a series of experiments whether the ethanolic extract of E. mucronatum (EEM) had any effect on performance and strength of rats undergoing resistance training. Methods: We promoted a supplementation with EEM and searched it increased strength, muscular endurance and reduced body fat in the rodents. Results: we registered a significant reduction in lipid peroxidation and an increase in superoxide dismutase in the exercised muscles. EEM supplementation did not alter the effect of exercise on blood pressure and heart rate. Additionally, we noticed a significant reduction in two markers of muscle damage, CK and LDH, but no alterations were observed in the levels of ALT and AST. Conclusions: The results showed that EEM was able to improve the physical performance of the rats without any remarkable adverse effects on hemodynamic variables, so it should be further investigated to examine whether it also has potential as an effective dietary supplement in humans to improve performance in resistance exercise cycles.http://www.sciencedirect.com/science/article/pii/S2667031322000161Resistance trainingPhysical conditioningAntioxidantEnzyme inhibitoryDietary supplements |
| spellingShingle | Elizabete Silva-Filha Nathanielly L. Silva Fabrício N. Macedo Luiz Ícaro C. Santos Andreza S. Santos Márcio R.V. Santos Marcelo C. Duarte Cícero F.S. Aragão Fernando H.A. Nogueira Adley A.N. Lima Gokhan Zengin Henrique Douglas Melo Coutinho Dulce M. Schimieguel Jullyana S.S. Quintans Lucindo J. Quintans-Júnior The effects of ethanolic extract of the leaves of Erythroxylum mucronatum (Benth.) (Erythroxylaceae) on strength and muscle performance of resistance trained rats Phytomedicine Plus Resistance training Physical conditioning Antioxidant Enzyme inhibitory Dietary supplements |
| title | The effects of ethanolic extract of the leaves of Erythroxylum mucronatum (Benth.) (Erythroxylaceae) on strength and muscle performance of resistance trained rats |
| title_full | The effects of ethanolic extract of the leaves of Erythroxylum mucronatum (Benth.) (Erythroxylaceae) on strength and muscle performance of resistance trained rats |
| title_fullStr | The effects of ethanolic extract of the leaves of Erythroxylum mucronatum (Benth.) (Erythroxylaceae) on strength and muscle performance of resistance trained rats |
| title_full_unstemmed | The effects of ethanolic extract of the leaves of Erythroxylum mucronatum (Benth.) (Erythroxylaceae) on strength and muscle performance of resistance trained rats |
| title_short | The effects of ethanolic extract of the leaves of Erythroxylum mucronatum (Benth.) (Erythroxylaceae) on strength and muscle performance of resistance trained rats |
| title_sort | effects of ethanolic extract of the leaves of erythroxylum mucronatum benth erythroxylaceae on strength and muscle performance of resistance trained rats |
| topic | Resistance training Physical conditioning Antioxidant Enzyme inhibitory Dietary supplements |
| url | http://www.sciencedirect.com/science/article/pii/S2667031322000161 |
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