The bright future of nanotechnology in lymphatic system imaging and imaging-guided surgery
Abstract Lymphatic system is identified the second vascular system after the blood circulation in mammalian species, however the research on lymphatic system has long been hampered by the lack of comprehensive imaging modality. Nanomaterials have shown the potential to enhance the quality of lymphat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-021-01232-5 |
| _version_ | 1828355528672149504 |
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| author | Shaolong Qi Xinyu Wang Kun Chang Wenbin Shen Guocan Yu Jianshi Du |
| author_facet | Shaolong Qi Xinyu Wang Kun Chang Wenbin Shen Guocan Yu Jianshi Du |
| author_sort | Shaolong Qi |
| collection | DOAJ |
| description | Abstract Lymphatic system is identified the second vascular system after the blood circulation in mammalian species, however the research on lymphatic system has long been hampered by the lack of comprehensive imaging modality. Nanomaterials have shown the potential to enhance the quality of lymphatic imaging due to the unparalleled advantages such as the specific passive targeting and efficient co-delivery of cocktail to peripheral lymphatic system, ease molecular engineering for precise active targeting and prolonged retention in the lymphatic system of interest. Multimodal lymphatic imaging based on nanotechnology provides a complementary means to understand the kinetics of lymphoid tissues and quantify its function. In this review, we introduce the established approaches of lymphatic imaging used in clinic and summarize their strengths and weaknesses, and list the critical influence factors on lymphatic imaging. Meanwhile, the recent developments in the field of pre-clinical lymphatic imaging are discussed to shed new lights on the design of new imaging agents, the improvement of delivery methods and imaging-guided surgery strategies. Graphical Abstract |
| first_indexed | 2024-04-14T02:43:47Z |
| format | Article |
| id | doaj.art-b1ab835d77a4419f9a5a06e9882c9c5f |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-14T02:43:47Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-b1ab835d77a4419f9a5a06e9882c9c5f2022-12-22T02:16:42ZengBMCJournal of Nanobiotechnology1477-31552022-01-0120112710.1186/s12951-021-01232-5The bright future of nanotechnology in lymphatic system imaging and imaging-guided surgeryShaolong Qi0Xinyu Wang1Kun Chang2Wenbin Shen3Guocan Yu4Jianshi Du5Key Laboratory & Engineering Laboratory of Lymphatic Surgery Jilin Province, China-Japan Union Hospital of Jilin UniversityKey Laboratory & Engineering Laboratory of Lymphatic Surgery Jilin Province, China-Japan Union Hospital of Jilin UniversityDepartment of Lymphology, Beijing Shijitan Hospital, Capital Medical UniversityDepartment of Lymphology, Beijing Shijitan Hospital, Capital Medical UniversityKey Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua UniversityKey Laboratory & Engineering Laboratory of Lymphatic Surgery Jilin Province, China-Japan Union Hospital of Jilin UniversityAbstract Lymphatic system is identified the second vascular system after the blood circulation in mammalian species, however the research on lymphatic system has long been hampered by the lack of comprehensive imaging modality. Nanomaterials have shown the potential to enhance the quality of lymphatic imaging due to the unparalleled advantages such as the specific passive targeting and efficient co-delivery of cocktail to peripheral lymphatic system, ease molecular engineering for precise active targeting and prolonged retention in the lymphatic system of interest. Multimodal lymphatic imaging based on nanotechnology provides a complementary means to understand the kinetics of lymphoid tissues and quantify its function. In this review, we introduce the established approaches of lymphatic imaging used in clinic and summarize their strengths and weaknesses, and list the critical influence factors on lymphatic imaging. Meanwhile, the recent developments in the field of pre-clinical lymphatic imaging are discussed to shed new lights on the design of new imaging agents, the improvement of delivery methods and imaging-guided surgery strategies. Graphical Abstracthttps://doi.org/10.1186/s12951-021-01232-5Lymphatic system imagingNanotechnologyLymphoscintigraphyMultimodal imagingImaging-guided surgery |
| spellingShingle | Shaolong Qi Xinyu Wang Kun Chang Wenbin Shen Guocan Yu Jianshi Du The bright future of nanotechnology in lymphatic system imaging and imaging-guided surgery Journal of Nanobiotechnology Lymphatic system imaging Nanotechnology Lymphoscintigraphy Multimodal imaging Imaging-guided surgery |
| title | The bright future of nanotechnology in lymphatic system imaging and imaging-guided surgery |
| title_full | The bright future of nanotechnology in lymphatic system imaging and imaging-guided surgery |
| title_fullStr | The bright future of nanotechnology in lymphatic system imaging and imaging-guided surgery |
| title_full_unstemmed | The bright future of nanotechnology in lymphatic system imaging and imaging-guided surgery |
| title_short | The bright future of nanotechnology in lymphatic system imaging and imaging-guided surgery |
| title_sort | bright future of nanotechnology in lymphatic system imaging and imaging guided surgery |
| topic | Lymphatic system imaging Nanotechnology Lymphoscintigraphy Multimodal imaging Imaging-guided surgery |
| url | https://doi.org/10.1186/s12951-021-01232-5 |
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