A Comparison of Nonlinear Measures for the Detection of Cardiac Autonomic Neuropathy from Heart Rate Variability
In this work we compare three multiscale measures for their ability to discriminate between participants having cardiac autonomic neuropathy (CAN) and aged controls. CAN is a disease that involves nerve damage leading to an abnormal control of heart rate, so one would expect disease progression to m...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-03-01
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| Series: | Entropy |
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| Online Access: | http://www.mdpi.com/1099-4300/17/3/1425 |
| _version_ | 1798006759752728576 |
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| author | David Cornforth Herbert F. Jelinek Mika Tarvainen |
| author_facet | David Cornforth Herbert F. Jelinek Mika Tarvainen |
| author_sort | David Cornforth |
| collection | DOAJ |
| description | In this work we compare three multiscale measures for their ability to discriminate between participants having cardiac autonomic neuropathy (CAN) and aged controls. CAN is a disease that involves nerve damage leading to an abnormal control of heart rate, so one would expect disease progression to manifest in changes to heart rate variability (HRV). We applied multiscale entropy (MSE), multi fractal detrended fluctuation analysis (MFDFA), and Renyi entropy (RE) to recorded datasets of RR intervals. The latter measure provided the best separation (lowest p-value in Mann–Whitney tests) between classes of participants having CAN, early CAN or no CAN (controls). This comparison suggests the efficacy of RE as a measure for diagnosis of CAN and its progression, when compared to the other multiscale measures. |
| first_indexed | 2024-04-11T12:59:43Z |
| format | Article |
| id | doaj.art-b1ad4fa3719740c9a1f29e9c11846cfb |
| institution | Directory Open Access Journal |
| issn | 1099-4300 |
| language | English |
| last_indexed | 2024-04-11T12:59:43Z |
| publishDate | 2015-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Entropy |
| spelling | doaj.art-b1ad4fa3719740c9a1f29e9c11846cfb2022-12-22T04:22:59ZengMDPI AGEntropy1099-43002015-03-011731425144010.3390/e17031425e17031425A Comparison of Nonlinear Measures for the Detection of Cardiac Autonomic Neuropathy from Heart Rate VariabilityDavid Cornforth0Herbert F. Jelinek1Mika Tarvainen2Applied Informatics Research Group, Faculty of Science and IT, University of Newcastle, Newcastle, NSW 2308, AustraliaCentre for Research in Complex Systems, School of Community Health, Charles Sturt University, Albury, NSW 2640, AustraliaUniversity of Eastern Finland, Kuopio 70210, FinlandIn this work we compare three multiscale measures for their ability to discriminate between participants having cardiac autonomic neuropathy (CAN) and aged controls. CAN is a disease that involves nerve damage leading to an abnormal control of heart rate, so one would expect disease progression to manifest in changes to heart rate variability (HRV). We applied multiscale entropy (MSE), multi fractal detrended fluctuation analysis (MFDFA), and Renyi entropy (RE) to recorded datasets of RR intervals. The latter measure provided the best separation (lowest p-value in Mann–Whitney tests) between classes of participants having CAN, early CAN or no CAN (controls). This comparison suggests the efficacy of RE as a measure for diagnosis of CAN and its progression, when compared to the other multiscale measures.http://www.mdpi.com/1099-4300/17/3/1425multiscale entropymulti fractal detrended fluctuation analysisRenyi entropyheart rate variabilitycardiac autonomic neuropathydisease discrimination |
| spellingShingle | David Cornforth Herbert F. Jelinek Mika Tarvainen A Comparison of Nonlinear Measures for the Detection of Cardiac Autonomic Neuropathy from Heart Rate Variability Entropy multiscale entropy multi fractal detrended fluctuation analysis Renyi entropy heart rate variability cardiac autonomic neuropathy disease discrimination |
| title | A Comparison of Nonlinear Measures for the Detection of Cardiac Autonomic Neuropathy from Heart Rate Variability |
| title_full | A Comparison of Nonlinear Measures for the Detection of Cardiac Autonomic Neuropathy from Heart Rate Variability |
| title_fullStr | A Comparison of Nonlinear Measures for the Detection of Cardiac Autonomic Neuropathy from Heart Rate Variability |
| title_full_unstemmed | A Comparison of Nonlinear Measures for the Detection of Cardiac Autonomic Neuropathy from Heart Rate Variability |
| title_short | A Comparison of Nonlinear Measures for the Detection of Cardiac Autonomic Neuropathy from Heart Rate Variability |
| title_sort | comparison of nonlinear measures for the detection of cardiac autonomic neuropathy from heart rate variability |
| topic | multiscale entropy multi fractal detrended fluctuation analysis Renyi entropy heart rate variability cardiac autonomic neuropathy disease discrimination |
| url | http://www.mdpi.com/1099-4300/17/3/1425 |
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