Clinical Significance of Hepsin and Underlying Signaling Pathways in Prostate Cancer
The hepsin gene encodes a type II transmembrane serine protease. Previous studies have shown the overexpression of hepsin in prostate cancer, and the dysregulation of hepsin promotes cancer cell proliferation, migration, and metastasis in vitro and in vivo. The review incorporated with our work show...
Main Authors: | Lucy Lu, Adam Cole, Dan Huang, Qiang Wang, Zhongming Guo, Wancai Yang, Jim Lu |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-01-01
|
Series: | Biomolecules |
Subjects: | |
Online Access: | https://www.mdpi.com/2218-273X/12/2/203 |
Similar Items
-
Implication of Hepsin from Primary Tumor in the Prognosis of Colorectal Cancer Patients
by: David Zaragoza-Huesca, et al.
Published: (2022-06-01) -
Hepsin immunohistochemical expression in prostate cancer in relation to Gleason′s grade and serum prostate specific antigen
by: Madhu Mati Goel, et al.
Published: (2011-01-01) -
Venetoclax is a potent hepsin inhibitor that reduces the metastatic and prothrombotic phenotypes of hepsin-expressing colorectal cancer cells
by: Maria Carmen Rodenas, et al.
Published: (2023-05-01) -
Design of drug-like hepsin inhibitors against prostate cancer and kidney stones
by: Vincent Blay, et al.
Published: (2020-07-01) -
The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin
by: Martina Brunati, et al.
Published: (2015-12-01)