The Effect of One Period of Endurance Training and Consumption of Hydroalcoholic Extract of Urtica Dioica on Oxidative Stress Indices of Heart Tissue in STZ-Induced Diabetic Rats
Introduction: Oxidative stress plays a key role in the onset and development of diabetes-related complications. Due to the antioxidant effect of exercise and Urtica dioica (UD), this study aimed to evaluate the effect of one period of endurance exercise and hydroalcoholic extract of Urtica dioica on...
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Ilam University of Medical Sciences
2023-06-01
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| Series: | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām |
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| Online Access: | http://sjimu.medilam.ac.ir/article-1-7709-en.pdf |
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| author | Ghafour Ghaffari Asghar Tofighi Masoud Rahmati Javad Tolouei Azar |
| author_facet | Ghafour Ghaffari Asghar Tofighi Masoud Rahmati Javad Tolouei Azar |
| author_sort | Ghafour Ghaffari |
| collection | DOAJ |
| description | Introduction: Oxidative stress plays a key role in the onset and development of diabetes-related complications. Due to the antioxidant effect of exercise and Urtica dioica (UD), this study aimed to evaluate the effect of one period of endurance exercise and hydroalcoholic extract of Urtica dioica on oxidative stress indices of heart tissue in STZ-Induced diabetic rats.
Material & Methods: In this study, 50 Wistar rats (mean±SD weight: 232.12±7.42 g) were randomly divided into five groups: Healthy-sedentary, Diabetes-sedentary, Diabetes-Exercise, Diabetes-Urtica dioica, and Diabetes-Exercise-Urtica dioica. Diabetes was induced by intraperitoneal injection of streptozotocin (45 mg/kg) and 48 hours after injection, blood glucose levels above 300 mg/dl were the criteria for the confirmation of diabetes. Endurance exercise with moderate intensity (5 days/week) and daily gavage of hydroalcoholic extract of UD was performed at 50 mg/kg for six weeks. Data were analyzed in SPSS software (version 20) through Shapiro-Wilk, two-way ANOVA, and Tukey post hoc test.
Findings: Two weeks after STZ injection, body weight in the Diabetes-Urtica dioica (P=0.001), Diabetes-Exercise (P=0.034), and Diabetes-Exercise-Urtica dioica (P=0.025) groups decreased, compared to the Healthy-sedentary group, and this reduction continued until the end of the sixth week. In addition, six weeks of endurance exercise and UD extract significantly reduced blood glucose concentration in the Diabetes-Exercise (P=0.001), Diabetes-Urtica dioica (P=0.001), and Diabetes-Exercise-Urtica dioica (P=0.001) groups, compared to the Diabetes-sedentary group. Furthermore, endurance training and UD extract caused a significant increase in catalase (P=0.019) and glutathione peroxidase (P=0.028) values and a significant decrease in heart tissue malondialdehyde (P=0.001).
Discussion & Conclusion: Six weeks of endurance training combined with UD extract can increase the antioxidant index and decrease lipid peroxidation in the heart tissue of diabetic rats with streptozotocin. |
| first_indexed | 2024-03-11T23:34:03Z |
| format | Article |
| id | doaj.art-b1b104dbc373437eb1ecf6f297e772b5 |
| institution | Directory Open Access Journal |
| issn | 1563-4728 2588-3135 |
| language | fas |
| last_indexed | 2024-03-11T23:34:03Z |
| publishDate | 2023-06-01 |
| publisher | Ilam University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām |
| spelling | doaj.art-b1b104dbc373437eb1ecf6f297e772b52023-09-20T05:53:26ZfasIlam University of Medical SciencesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām1563-47282588-31352023-06-013121530The Effect of One Period of Endurance Training and Consumption of Hydroalcoholic Extract of Urtica Dioica on Oxidative Stress Indices of Heart Tissue in STZ-Induced Diabetic RatsGhafour Ghaffari0Asghar Tofighi1Masoud Rahmati2Javad Tolouei Azar3 Dept of Exercise Physiology and Corrective Exercises, Faculty of Sport Sciences, Urmia University, Urmia, Iran Dept of Exercise Physiology and Corrective Exercises, Faculty of Sport Sciences, Urmia University, Urmia, Iran Dept of Exercise Physiology, Faculty of Literature and Humanities, Lorestan University, Khorramabad, Iran Dept of Exercise Physiology and Corrective Exercises, Faculty of Sport Sciences, Urmia University, Urmia, Iran Introduction: Oxidative stress plays a key role in the onset and development of diabetes-related complications. Due to the antioxidant effect of exercise and Urtica dioica (UD), this study aimed to evaluate the effect of one period of endurance exercise and hydroalcoholic extract of Urtica dioica on oxidative stress indices of heart tissue in STZ-Induced diabetic rats. Material & Methods: In this study, 50 Wistar rats (mean±SD weight: 232.12±7.42 g) were randomly divided into five groups: Healthy-sedentary, Diabetes-sedentary, Diabetes-Exercise, Diabetes-Urtica dioica, and Diabetes-Exercise-Urtica dioica. Diabetes was induced by intraperitoneal injection of streptozotocin (45 mg/kg) and 48 hours after injection, blood glucose levels above 300 mg/dl were the criteria for the confirmation of diabetes. Endurance exercise with moderate intensity (5 days/week) and daily gavage of hydroalcoholic extract of UD was performed at 50 mg/kg for six weeks. Data were analyzed in SPSS software (version 20) through Shapiro-Wilk, two-way ANOVA, and Tukey post hoc test. Findings: Two weeks after STZ injection, body weight in the Diabetes-Urtica dioica (P=0.001), Diabetes-Exercise (P=0.034), and Diabetes-Exercise-Urtica dioica (P=0.025) groups decreased, compared to the Healthy-sedentary group, and this reduction continued until the end of the sixth week. In addition, six weeks of endurance exercise and UD extract significantly reduced blood glucose concentration in the Diabetes-Exercise (P=0.001), Diabetes-Urtica dioica (P=0.001), and Diabetes-Exercise-Urtica dioica (P=0.001) groups, compared to the Diabetes-sedentary group. Furthermore, endurance training and UD extract caused a significant increase in catalase (P=0.019) and glutathione peroxidase (P=0.028) values and a significant decrease in heart tissue malondialdehyde (P=0.001). Discussion & Conclusion: Six weeks of endurance training combined with UD extract can increase the antioxidant index and decrease lipid peroxidation in the heart tissue of diabetic rats with streptozotocin.http://sjimu.medilam.ac.ir/article-1-7709-en.pdfdiabetesendurance exerciseheart tissueoxidative stressurtica dioica |
| spellingShingle | Ghafour Ghaffari Asghar Tofighi Masoud Rahmati Javad Tolouei Azar The Effect of One Period of Endurance Training and Consumption of Hydroalcoholic Extract of Urtica Dioica on Oxidative Stress Indices of Heart Tissue in STZ-Induced Diabetic Rats Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām diabetes endurance exercise heart tissue oxidative stress urtica dioica |
| title | The Effect of One Period of Endurance Training and Consumption of Hydroalcoholic Extract of Urtica Dioica on Oxidative Stress Indices of Heart Tissue in STZ-Induced Diabetic Rats |
| title_full | The Effect of One Period of Endurance Training and Consumption of Hydroalcoholic Extract of Urtica Dioica on Oxidative Stress Indices of Heart Tissue in STZ-Induced Diabetic Rats |
| title_fullStr | The Effect of One Period of Endurance Training and Consumption of Hydroalcoholic Extract of Urtica Dioica on Oxidative Stress Indices of Heart Tissue in STZ-Induced Diabetic Rats |
| title_full_unstemmed | The Effect of One Period of Endurance Training and Consumption of Hydroalcoholic Extract of Urtica Dioica on Oxidative Stress Indices of Heart Tissue in STZ-Induced Diabetic Rats |
| title_short | The Effect of One Period of Endurance Training and Consumption of Hydroalcoholic Extract of Urtica Dioica on Oxidative Stress Indices of Heart Tissue in STZ-Induced Diabetic Rats |
| title_sort | effect of one period of endurance training and consumption of hydroalcoholic extract of urtica dioica on oxidative stress indices of heart tissue in stz induced diabetic rats |
| topic | diabetes endurance exercise heart tissue oxidative stress urtica dioica |
| url | http://sjimu.medilam.ac.ir/article-1-7709-en.pdf |
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