Oleoylethanolamide Modulates BDNF-ERK Signaling and Neurogenesis in the Hippocampi of Rats Exposed to Δ9-THC and Ethanol Binge Drinking During Adolescence

Oleoylethanolamide Modulates BDNF-ERK Signaling and Neurogenesis in the Hippocampi of Rats Exposed to Δ9-THC and Ethanol Binge Drinking During Adolescence

Oleoylethanolamide is an endogenous NAE that modulates ethanol-seeking behavior and ethanol-induced neuroinflammation. In the present study we further analyze the role of OEA in hippocampal neurogenesis, BDNF-ERK signaling, and spatial memory that are affected by alcohol. Additionally, we addressed...

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Bibliographic Details
Main Authors: Daniel Silva-Peña, Patricia Rivera, Francisco Alén, Antonio Vargas, Leticia Rubio, Nuria García-Marchena, Francisco Javier Pavón, Antonia Serrano, Fernando Rodríguez de Fonseca, Juan Suárez
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
alcohol
brain-derived neurotrophic factor
ERK
hippocampus
memory
oleoylethanolamide
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00096/full

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