Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism

Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism

CDK9 is the kinase subunit of positive transcription elongation factor b (P-TEFb) that enables RNA polymerase (Pol) II's transition from promoter-proximal pausing to productive elongation. Although considerable interest exists in CDK9 as a therapeutic target, little progress has been made due t...

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Bibliographic Details
Main Authors: Huasong Lu, Yuhua Xue, Guoying K Yu, Carolina Arias, Julie Lin, Susan Fong, Michel Faure, Ben Weisburd, Xiaodan Ji, Alexandre Mercier, James Sutton, Kunxin Luo, Zhenhai Gao, Qiang Zhou
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-06-01
Series:eLife
Subjects:
MYC
CDK9
BRD4
CDK9 inhibitor
RNA polymerase pause and release
transcriptional elongation
Online Access:https://elifesciences.org/articles/06535

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