COVID-19 pandemic: protective role of vitamin D
Introduction. The COVID-19 pandemic revealed the vulnerability of the general population to this infectious disease, which is determined by the lack of immunity to the new SARS-CoV-2 coronavirus and is characterized by cytokine storm in severe cases. One of the most important reasons for this vulner...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2020-08-01
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| Series: | Фармакоэкономика |
| Subjects: | |
| Online Access: | https://www.pharmacoeconomics.ru/jour/article/view/386 |
| _version_ | 1797878895498756096 |
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| author | O. A. Gromova I. Yu. Torshin G. Kh. Gabdulina |
| author_facet | O. A. Gromova I. Yu. Torshin G. Kh. Gabdulina |
| author_sort | O. A. Gromova |
| collection | DOAJ |
| description | Introduction. The COVID-19 pandemic revealed the vulnerability of the general population to this infectious disease, which is determined by the lack of immunity to the new SARS-CoV-2 coronavirus and is characterized by cytokine storm in severe cases. One of the most important reasons for this vulnerability is a high occurrence rate of micronutrient deficiencies, and above all, vitamin D deficiency.Aim. To systematize the available data on the role of vitamin D in the prevention of COVID-19 infection.Materials and methods. Systematic computer analysis of the entire array of available scientific publications on coronaviruses (21,300 publications in PUBMED and preprint repositories, including 7,500 publications on COVID-19 and SARS-CoV-2) was performed. The methods of topological and metric data analysis were used. About 50 most informative sections were identified that were mainly associated with COVID-19 / SARS-CoV-2. The analysis of the obtained “map” of molecular pathophysiology of COVID-19 was performed.Results. Vitamin D activates the expression of many genes involved in supporting the immunity against coronaviruses and other singlestranded RNA viruses (interferon-dependent protection). The results of the systematic analysis of the publications on coronavirus showed that vitamin D is important for attenuating the effects of the cytokine storm and compensating for chronic comorbid pathologies.Conclusion. The compensation for vitamin D deficiency is an essential component of COVID-19 prevention. This tactics of prevention is less costly than managing patients with severe forms of COVID-19 and can help save public healthcare resources. |
| first_indexed | 2024-04-10T02:40:20Z |
| format | Article |
| id | doaj.art-b1b436cf9868405e87593345dc2d4a03 |
| institution | Directory Open Access Journal |
| issn | 2070-4909 2070-4933 |
| language | Russian |
| last_indexed | 2024-04-10T02:40:20Z |
| publishDate | 2020-08-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Фармакоэкономика |
| spelling | doaj.art-b1b436cf9868405e87593345dc2d4a032023-03-13T07:48:17ZrusIRBIS LLCФармакоэкономика2070-49092070-49332020-08-0113213214510.17749/2070-4909/farmakoekonomika.2020.044299COVID-19 pandemic: protective role of vitamin DO. A. Gromova0I. Yu. Torshin1G. Kh. Gabdulina2V.A. Nasonov Research Institute of Rheumatology; Federal Research Center “Informatics and Management of the Russian Academy of Sciences“V.A. Nasonov Research Institute of Rheumatology; Federal Research Center “Informatics and Management of the Russian Academy of Sciences“Kazakh National Medical University named after S. D. AsfendiyarovaIntroduction. The COVID-19 pandemic revealed the vulnerability of the general population to this infectious disease, which is determined by the lack of immunity to the new SARS-CoV-2 coronavirus and is characterized by cytokine storm in severe cases. One of the most important reasons for this vulnerability is a high occurrence rate of micronutrient deficiencies, and above all, vitamin D deficiency.Aim. To systematize the available data on the role of vitamin D in the prevention of COVID-19 infection.Materials and methods. Systematic computer analysis of the entire array of available scientific publications on coronaviruses (21,300 publications in PUBMED and preprint repositories, including 7,500 publications on COVID-19 and SARS-CoV-2) was performed. The methods of topological and metric data analysis were used. About 50 most informative sections were identified that were mainly associated with COVID-19 / SARS-CoV-2. The analysis of the obtained “map” of molecular pathophysiology of COVID-19 was performed.Results. Vitamin D activates the expression of many genes involved in supporting the immunity against coronaviruses and other singlestranded RNA viruses (interferon-dependent protection). The results of the systematic analysis of the publications on coronavirus showed that vitamin D is important for attenuating the effects of the cytokine storm and compensating for chronic comorbid pathologies.Conclusion. The compensation for vitamin D deficiency is an essential component of COVID-19 prevention. This tactics of prevention is less costly than managing patients with severe forms of COVID-19 and can help save public healthcare resources.https://www.pharmacoeconomics.ru/jour/article/view/386covid-19rna virusesmicronutrientscholecalciferolaquadetrimspraydetrim |
| spellingShingle | O. A. Gromova I. Yu. Torshin G. Kh. Gabdulina COVID-19 pandemic: protective role of vitamin D Фармакоэкономика covid-19 rna viruses micronutrients cholecalciferol aquadetrim spraydetrim |
| title | COVID-19 pandemic: protective role of vitamin D |
| title_full | COVID-19 pandemic: protective role of vitamin D |
| title_fullStr | COVID-19 pandemic: protective role of vitamin D |
| title_full_unstemmed | COVID-19 pandemic: protective role of vitamin D |
| title_short | COVID-19 pandemic: protective role of vitamin D |
| title_sort | covid 19 pandemic protective role of vitamin d |
| topic | covid-19 rna viruses micronutrients cholecalciferol aquadetrim spraydetrim |
| url | https://www.pharmacoeconomics.ru/jour/article/view/386 |
| work_keys_str_mv | AT oagromova covid19pandemicprotectiveroleofvitamind AT iyutorshin covid19pandemicprotectiveroleofvitamind AT gkhgabdulina covid19pandemicprotectiveroleofvitamind |