The Molecular Basis for Remyelination Failure in Multiple Sclerosis

The Molecular Basis for Remyelination Failure in Multiple Sclerosis

Myelin sheaths in the central nervous system (CNS) insulate axons and thereby allow saltatory nerve conduction, which is a prerequisite for complex brain function. Multiple sclerosis (MS), the most common inflammatory autoimmune disease of the CNS, leads to the destruction of myelin sheaths and the...

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Bibliographic Details
Main Authors: Joel Gruchot, Vivien Weyers, Peter Göttle, Moritz Förster, Hans-Peter Hartung, Patrick Küry, David Kremer
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cells
Subjects:
multiple sclerosis
remyelination
oligodendroglial precursor cells
neural stem cells
microglia
Online Access:https://www.mdpi.com/2073-4409/8/8/825

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