Nutraceutical with a promising oral anticancer effect: in vitro study on apricot oil extract
Abstract Background One of the major threats to human health is malignancy. Treatment regimens usually followed by either chemo or radiotherapy have a wide range of collateral unwanted side effects. Scientists seek alternatives with less or no adverse consequences. Nutraceuticals possess disease-mod...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-01-01
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| Series: | Bulletin of the National Research Centre |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42269-022-00976-w |
| _version_ | 1797958827388174336 |
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| author | Marwa Mohamed Ellithy Heba Elsayed Tarek Heba Nader Shalash |
| author_facet | Marwa Mohamed Ellithy Heba Elsayed Tarek Heba Nader Shalash |
| author_sort | Marwa Mohamed Ellithy |
| collection | DOAJ |
| description | Abstract Background One of the major threats to human health is malignancy. Treatment regimens usually followed by either chemo or radiotherapy have a wide range of collateral unwanted side effects. Scientists seek alternatives with less or no adverse consequences. Nutraceuticals possess disease-modifying implications in medicine related to Alzheimer’s, cardiovascular, Parkinson’s diseases and malignancy. Apricot oil extract is one such nutraceutical. Its active component is amygdalin, known also as vitamin B.17 or laetrile. It is found in a wide range of vegetable species. Amygdalin is found in high concentration in the kernels of rosaceous fruits such as bitter nuts and apricot kernels. Amygdalin is an aromatic cyanogenic component with a glycoside group. It has a diverse effect on different systems and organs of the body. Recently, it has shown an anticancer potential as it can decompose carcinogenic elements found in the body and kill malignant cells, so it results in cancer growth inhibition. There is a great debate related to the cyanide toxicity of amygdalin. The presented study aims to evaluate apricot oil extract’s impact on squamous cell carcinoma of the tongue, HNO97, while testing its safety on non-tumorigenic oral epithelial cells. Results HNO97 cell line viability was markedly decreased. This may be induced by the upregulation of autophagy, apoptosis enhancement as well as cell cycle arrest. Cancer cell migration was also decreased. Apricot oil caused no significant inhibition of normal OEC viability in low doses. Conclusions Apricot oil extract from apricot kernel had a notably antitumorigenic impact on oral cancer cells. It may be later subjected to pre- as well as clinical trials. |
| first_indexed | 2024-04-11T00:25:21Z |
| format | Article |
| id | doaj.art-b1ba4b18133e491c94466337acc15715 |
| institution | Directory Open Access Journal |
| issn | 2522-8307 |
| language | English |
| last_indexed | 2024-04-11T00:25:21Z |
| publishDate | 2023-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Bulletin of the National Research Centre |
| spelling | doaj.art-b1ba4b18133e491c94466337acc157152023-01-08T12:04:14ZengSpringerOpenBulletin of the National Research Centre2522-83072023-01-0147111310.1186/s42269-022-00976-wNutraceutical with a promising oral anticancer effect: in vitro study on apricot oil extractMarwa Mohamed Ellithy0Heba Elsayed Tarek1Heba Nader Shalash2Basic Dental Science Department, Oral and Dental Research Institute, National Research CentreBasic Dental Science Department, Oral and Dental Research Institute, National Research CentreBasic Dental Science Department, Oral and Dental Research Institute, National Research CentreAbstract Background One of the major threats to human health is malignancy. Treatment regimens usually followed by either chemo or radiotherapy have a wide range of collateral unwanted side effects. Scientists seek alternatives with less or no adverse consequences. Nutraceuticals possess disease-modifying implications in medicine related to Alzheimer’s, cardiovascular, Parkinson’s diseases and malignancy. Apricot oil extract is one such nutraceutical. Its active component is amygdalin, known also as vitamin B.17 or laetrile. It is found in a wide range of vegetable species. Amygdalin is found in high concentration in the kernels of rosaceous fruits such as bitter nuts and apricot kernels. Amygdalin is an aromatic cyanogenic component with a glycoside group. It has a diverse effect on different systems and organs of the body. Recently, it has shown an anticancer potential as it can decompose carcinogenic elements found in the body and kill malignant cells, so it results in cancer growth inhibition. There is a great debate related to the cyanide toxicity of amygdalin. The presented study aims to evaluate apricot oil extract’s impact on squamous cell carcinoma of the tongue, HNO97, while testing its safety on non-tumorigenic oral epithelial cells. Results HNO97 cell line viability was markedly decreased. This may be induced by the upregulation of autophagy, apoptosis enhancement as well as cell cycle arrest. Cancer cell migration was also decreased. Apricot oil caused no significant inhibition of normal OEC viability in low doses. Conclusions Apricot oil extract from apricot kernel had a notably antitumorigenic impact on oral cancer cells. It may be later subjected to pre- as well as clinical trials.https://doi.org/10.1186/s42269-022-00976-wApricot oilAmygdalinVitamin B17LaetrileTongue carcinoma |
| spellingShingle | Marwa Mohamed Ellithy Heba Elsayed Tarek Heba Nader Shalash Nutraceutical with a promising oral anticancer effect: in vitro study on apricot oil extract Bulletin of the National Research Centre Apricot oil Amygdalin Vitamin B17 Laetrile Tongue carcinoma |
| title | Nutraceutical with a promising oral anticancer effect: in vitro study on apricot oil extract |
| title_full | Nutraceutical with a promising oral anticancer effect: in vitro study on apricot oil extract |
| title_fullStr | Nutraceutical with a promising oral anticancer effect: in vitro study on apricot oil extract |
| title_full_unstemmed | Nutraceutical with a promising oral anticancer effect: in vitro study on apricot oil extract |
| title_short | Nutraceutical with a promising oral anticancer effect: in vitro study on apricot oil extract |
| title_sort | nutraceutical with a promising oral anticancer effect in vitro study on apricot oil extract |
| topic | Apricot oil Amygdalin Vitamin B17 Laetrile Tongue carcinoma |
| url | https://doi.org/10.1186/s42269-022-00976-w |
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