Novel Non-invasive Fractional Flow Reserve from Coronary CT Angiography to Determine Ischemic Coronary Stenosis
Coronary artery disease (CAD) patients may have an obstructive disease on invasive coronary angiography, but few of these patients have had flow-limiting obstructive disease diagnosed on invasive fractional flow reserve (FFR). FFR is infrequently performed because of its cost- and time-effectiveness...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Radcliffe Medical Media
2021-04-01
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| Series: | US Cardiology Review |
| Online Access: | https://www.uscjournal.com/articleindex/usc.2020.24 |
| _version_ | 1797200068143480832 |
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| author | Lavanya Cherukuri Divya Birudaraju Matthew J Budoff |
| author_facet | Lavanya Cherukuri Divya Birudaraju Matthew J Budoff |
| author_sort | Lavanya Cherukuri |
| collection | DOAJ |
| description | Coronary artery disease (CAD) patients may have an obstructive disease on invasive coronary angiography, but few of these patients have had flow-limiting obstructive disease diagnosed on invasive fractional flow reserve (FFR). FFR is infrequently performed because of its cost- and time-effectiveness. Advancement in non-invasive imaging has enabled FFR to be derived non-invasively using coronary CT angiography (CCTA), without the need for induction of hyperemia or modification of the standard CCTA acquisition protocol. FFR derived from CCTA (FFRCT) has been shown to have excellent correlation with invasive FFR, and remains an effective diagnostic tool in the presence of reduced signal-to-noise ratio, coronary calcification and motion artifact. The utility of FFRCT has also helped to deepen our understanding of hemodynamically significant CAD. Hence, there is now interest in exploring the possible interplay between these mechanistic forces and their effect on the development of coronary plaque and the vulnerability of these plaques. |
| first_indexed | 2024-03-07T17:41:15Z |
| format | Article |
| id | doaj.art-b1ba96ed4af5457da19b01d480e49e9c |
| institution | Directory Open Access Journal |
| issn | 1758-3896 1758-390X |
| language | English |
| last_indexed | 2024-04-24T07:25:46Z |
| publishDate | 2021-04-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | US Cardiology Review |
| spelling | doaj.art-b1ba96ed4af5457da19b01d480e49e9c2024-04-20T16:02:11ZengRadcliffe Medical MediaUS Cardiology Review1758-38961758-390X2021-04-011510.15420/usc.2020.24Novel Non-invasive Fractional Flow Reserve from Coronary CT Angiography to Determine Ischemic Coronary StenosisLavanya Cherukuri0Divya Birudaraju1Matthew J Budoff2The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CAThe Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CAThe Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA; Division of Cardiology, Harbor-UCLA Medical Center, Torrance, CACoronary artery disease (CAD) patients may have an obstructive disease on invasive coronary angiography, but few of these patients have had flow-limiting obstructive disease diagnosed on invasive fractional flow reserve (FFR). FFR is infrequently performed because of its cost- and time-effectiveness. Advancement in non-invasive imaging has enabled FFR to be derived non-invasively using coronary CT angiography (CCTA), without the need for induction of hyperemia or modification of the standard CCTA acquisition protocol. FFR derived from CCTA (FFRCT) has been shown to have excellent correlation with invasive FFR, and remains an effective diagnostic tool in the presence of reduced signal-to-noise ratio, coronary calcification and motion artifact. The utility of FFRCT has also helped to deepen our understanding of hemodynamically significant CAD. Hence, there is now interest in exploring the possible interplay between these mechanistic forces and their effect on the development of coronary plaque and the vulnerability of these plaques.https://www.uscjournal.com/articleindex/usc.2020.24 |
| spellingShingle | Lavanya Cherukuri Divya Birudaraju Matthew J Budoff Novel Non-invasive Fractional Flow Reserve from Coronary CT Angiography to Determine Ischemic Coronary Stenosis US Cardiology Review |
| title | Novel Non-invasive Fractional Flow Reserve from Coronary CT Angiography to Determine Ischemic Coronary Stenosis |
| title_full | Novel Non-invasive Fractional Flow Reserve from Coronary CT Angiography to Determine Ischemic Coronary Stenosis |
| title_fullStr | Novel Non-invasive Fractional Flow Reserve from Coronary CT Angiography to Determine Ischemic Coronary Stenosis |
| title_full_unstemmed | Novel Non-invasive Fractional Flow Reserve from Coronary CT Angiography to Determine Ischemic Coronary Stenosis |
| title_short | Novel Non-invasive Fractional Flow Reserve from Coronary CT Angiography to Determine Ischemic Coronary Stenosis |
| title_sort | novel non invasive fractional flow reserve from coronary ct angiography to determine ischemic coronary stenosis |
| url | https://www.uscjournal.com/articleindex/usc.2020.24 |
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