Identification, replication and characterization of epigenetic remodelling in the aging genome: a cross population analysis
Abstract Aging is a complex biological process regulated by multiple cellular pathways and molecular mechanisms including epigenetics. Using genome-wide DNA methylation data measured in a large collection of Scottish old individuals, we performed discovery association analysis to identify age-methyl...
Main Authors: | Shuxia Li, Lene Christiansen, Kaare Christensen, Torben A. Kruse, Paul Redmond, Riccardo E. Marioni, Ian J. Deary, Qihua Tan |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2017-08-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-017-08346-7 |
Similar Items
-
Epigenetic signature of preterm birth in adult twins
by: Qihua Tan, et al.
Published: (2018-06-01) -
Retrospective analysis of main and interaction effects in genetic association studies of human complex traits
by: Brasch-Andersen Charlotte, et al.
Published: (2007-10-01) -
A Genome-Wide Integrative Association Study of DNA Methylation and Gene Expression Data and Later Life Cognitive Functioning in Monozygotic Twins
by: Mette Soerensen, et al.
Published: (2020-04-01) -
Association of facial ageing with DNA methylation and epigenetic age predictions
by: Riccardo E. Marioni, et al.
Published: (2018-11-01) -
DNA methylation and the epigenetic clock in relation to physical frailty in older people: the Lothian Birth Cohort 1936
by: Catharine R. Gale, et al.
Published: (2018-08-01)