Evaluation of flow of chorioretinal capillaries in healthy black and white subjects using optical coherence tomography angiography
Abstract This study compared macular capillary parameters between healthy black and white subjects using optical coherence tomography angiography (OCTA). We measured vessel density (VD) of superficial (SCP), intermediate (ICP), and deep (DCP) capillary plexuses and choriocapillaris blood flow area (...
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Nature Portfolio
2021-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-01380-6 |
| _version_ | 1798034935945101312 |
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| author | Nathalie Massamba Anna G. Mackin Lindsay Y. Chun Sarah Rodriguez Rose C. Dimitroyannis Bahram Bodaghi Seenu M. Hariprasad Dimitra Skondra |
| author_facet | Nathalie Massamba Anna G. Mackin Lindsay Y. Chun Sarah Rodriguez Rose C. Dimitroyannis Bahram Bodaghi Seenu M. Hariprasad Dimitra Skondra |
| author_sort | Nathalie Massamba |
| collection | DOAJ |
| description | Abstract This study compared macular capillary parameters between healthy black and white subjects using optical coherence tomography angiography (OCTA). We measured vessel density (VD) of superficial (SCP), intermediate (ICP), and deep (DCP) capillary plexuses and choriocapillaris blood flow area (BFA) of the fovea, parafovea and total 3 mm-diameter circular area centered on the fovea, as well as the foveal avascular zone (FAZ) parameters, controlling for axial length. Black subjects had lower foveal and parafoveal VD in the SCP (p = 0.043 and p = 0.014) and the ICP (p = 0.014 and p = 0.002). In the DCP, black subjects had a trend toward lower foveal and parafoveal VD. Black subjects had decreased choriocapillaris BFA in the total 3 mm area (p = 0.011) and the parafovea (p = 0.033), larger FAZ area (p = 0.006) and perimeter (p = 0.014), and a higher capillary density in a 300 μm wide region around the FAZ (FD-300) (p = 0.001). There was no significant difference in FAZ acircularity index. To our knowledge, this is the first report analyzing the three distinct retinal capillary plexuses and identifying differing baseline VD, choriocapillaris and FAZ parameters in healthy young black compared to white subjects. Larger studies are needed to validate these findings and better understand racial differences in vulnerability to ocular diseases. |
| first_indexed | 2024-04-11T20:51:17Z |
| format | Article |
| id | doaj.art-b1bc4d0b885a4b5598816a77b0f8c5a6 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T20:51:17Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b1bc4d0b885a4b5598816a77b0f8c5a62022-12-22T04:03:51ZengNature PortfolioScientific Reports2045-23222021-11-011111910.1038/s41598-021-01380-6Evaluation of flow of chorioretinal capillaries in healthy black and white subjects using optical coherence tomography angiographyNathalie Massamba0Anna G. Mackin1Lindsay Y. Chun2Sarah Rodriguez3Rose C. Dimitroyannis4Bahram Bodaghi5Seenu M. Hariprasad6Dimitra Skondra7Department of Ophthalmology and Visual Science, The University of ChicagoDepartment of Ophthalmology and Visual Science, The University of ChicagoDepartment of Ophthalmology and Visual Science, The University of ChicagoDepartment of Ophthalmology and Visual Science, The University of ChicagoDepartment of Ophthalmology and Visual Science, The University of ChicagoDepartment of Ophthalmology, Handicap, and Vision, Pitie Salpetriere Hospital, Sorbonne UniversityDepartment of Ophthalmology and Visual Science, The University of ChicagoDepartment of Ophthalmology and Visual Science, The University of ChicagoAbstract This study compared macular capillary parameters between healthy black and white subjects using optical coherence tomography angiography (OCTA). We measured vessel density (VD) of superficial (SCP), intermediate (ICP), and deep (DCP) capillary plexuses and choriocapillaris blood flow area (BFA) of the fovea, parafovea and total 3 mm-diameter circular area centered on the fovea, as well as the foveal avascular zone (FAZ) parameters, controlling for axial length. Black subjects had lower foveal and parafoveal VD in the SCP (p = 0.043 and p = 0.014) and the ICP (p = 0.014 and p = 0.002). In the DCP, black subjects had a trend toward lower foveal and parafoveal VD. Black subjects had decreased choriocapillaris BFA in the total 3 mm area (p = 0.011) and the parafovea (p = 0.033), larger FAZ area (p = 0.006) and perimeter (p = 0.014), and a higher capillary density in a 300 μm wide region around the FAZ (FD-300) (p = 0.001). There was no significant difference in FAZ acircularity index. To our knowledge, this is the first report analyzing the three distinct retinal capillary plexuses and identifying differing baseline VD, choriocapillaris and FAZ parameters in healthy young black compared to white subjects. Larger studies are needed to validate these findings and better understand racial differences in vulnerability to ocular diseases.https://doi.org/10.1038/s41598-021-01380-6 |
| spellingShingle | Nathalie Massamba Anna G. Mackin Lindsay Y. Chun Sarah Rodriguez Rose C. Dimitroyannis Bahram Bodaghi Seenu M. Hariprasad Dimitra Skondra Evaluation of flow of chorioretinal capillaries in healthy black and white subjects using optical coherence tomography angiography Scientific Reports |
| title | Evaluation of flow of chorioretinal capillaries in healthy black and white subjects using optical coherence tomography angiography |
| title_full | Evaluation of flow of chorioretinal capillaries in healthy black and white subjects using optical coherence tomography angiography |
| title_fullStr | Evaluation of flow of chorioretinal capillaries in healthy black and white subjects using optical coherence tomography angiography |
| title_full_unstemmed | Evaluation of flow of chorioretinal capillaries in healthy black and white subjects using optical coherence tomography angiography |
| title_short | Evaluation of flow of chorioretinal capillaries in healthy black and white subjects using optical coherence tomography angiography |
| title_sort | evaluation of flow of chorioretinal capillaries in healthy black and white subjects using optical coherence tomography angiography |
| url | https://doi.org/10.1038/s41598-021-01380-6 |
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