Somatic Accumulation of GluA1-AMPA Receptors Leads to Selective Cognitive Impairments in Mice

Somatic Accumulation of GluA1-AMPA Receptors Leads to Selective Cognitive Impairments in Mice

The GluA1 subunit of the L-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) plays a crucial, but highly selective, role in cognitive function. Here we analyzed AMPAR expression, AMPAR distribution and spatial learning in mice (Gria1R/R), expressing the “trafficking compromised”...

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Bibliographic Details
Main Authors: David M. Bannerman, Thilo Borchardt, Vidar Jensen, Andrey Rozov, Nadia N. Haj-Yasein, Nail Burnashev, Daniel Zamanillo, Thorsten Bus, Isabel Grube, Giselind Adelmann, J. Nicholas P. Rawlins, Rolf Sprengel
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
AMPA receptors
GluA1
long-term potentiation
Morris water-maze
RNA-editing
spatial memory
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00199/full

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