Case report: Therapeutic potential of T-VEC in combination with MEK inhibitors in melanoma patients with NRAS mutation

Case report: Therapeutic potential of T-VEC in combination with MEK inhibitors in melanoma patients with NRAS mutation

Mutations in the NRAS gene are common alterations in malignant melanoma. However, there are no specific treatment options approved for NRAS-mutated melanoma patients besides immune checkpoint inhibition. Since preclinical data suggests a synergistic effect of a MEK inhibitor (MEKi) and the oncolytic...

Full description

Bibliographic Details
Main Authors: Sonja C. S. Simon, Verena Müller, Jochen S. Utikal
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Oncology
Subjects:
melanoma
T-VEC
MEK inhibitor
NRAS mutation
case series
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1111119/full

Similar Items

Similar Items