Curcumin-Loaded Hydrophobic Surface-Modified Hydroxyapatite as an Antioxidant for Sarcopenia Prevention
Oxidative stress and later-induced chronic inflammation have been reported to play an important role on the progression of sarcopenia. Current treatments for sarcopenia are mainly administered to patients whom sarcopenia already developed. However, there has been no promising results shown in therap...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/4/616 |
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| author | Ya-Jyun Liang I-Hsuan Yang Yi-Wen Lin Jhih-Ni Lin Chang-Chin Wu Chih-Yung Chiang Kun-Hung Lai Feng-Huei Lin |
| author_facet | Ya-Jyun Liang I-Hsuan Yang Yi-Wen Lin Jhih-Ni Lin Chang-Chin Wu Chih-Yung Chiang Kun-Hung Lai Feng-Huei Lin |
| author_sort | Ya-Jyun Liang |
| collection | DOAJ |
| description | Oxidative stress and later-induced chronic inflammation have been reported to play an important role on the progression of sarcopenia. Current treatments for sarcopenia are mainly administered to patients whom sarcopenia already developed. However, there has been no promising results shown in therapy. Therefore, the development of therapeutic and preventive strategies against sarcopenia would be necessary. Curcumin is a traditional medicine that possesses anti-inflammatory and antioxidative properties. In the present study, hydroxyapatite was subjected to hydrophobic surface modifications for curcumin loading (Cur-SHAP). It was, subsequently, utilized for delivery to the patient’s body via intramuscular injection in order to achieve constant release for more than 2 weeks, preventing the progression of the sarcopenia or even leading to recovery from the early stage of the illness. According to the results of WST-1, LIVE/DEAD, DCFDA, and gene expression assays, Cur-SHAP exhibited good biocompatibility and showed great antioxidant/anti-inflammatory effects through the endocytic pathway. The results of the animal studies showed that the muscle endurance, grip strength, and fat/lean mass ratio were all improved in Cur-SHAP-treated rats from LPS-induced sarcopenia. In summary, we successfully synthesized hydrophobic surface modification hydroxyapatite for curcumin loading (Cur-SHAP) and drug delivery via the IM route. The LPS-induced sarcopenia rats were able to recover from disease after the Cur-SHAP treatment. |
| first_indexed | 2024-03-10T12:15:40Z |
| format | Article |
| id | doaj.art-b1bfffda617d4ea290bef6525f98ba46 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T12:15:40Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-b1bfffda617d4ea290bef6525f98ba462023-11-21T15:54:53ZengMDPI AGAntioxidants2076-39212021-04-0110461610.3390/antiox10040616Curcumin-Loaded Hydrophobic Surface-Modified Hydroxyapatite as an Antioxidant for Sarcopenia PreventionYa-Jyun Liang0I-Hsuan Yang1Yi-Wen Lin2Jhih-Ni Lin3Chang-Chin Wu4Chih-Yung Chiang5Kun-Hung Lai6Feng-Huei Lin7Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei 10617, TaiwanInstitute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei 10617, TaiwanInstitute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei 10617, TaiwanInstitute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei 10617, TaiwanDepartment of Orthopedics, En Chu Kong Hospital, New Taipei City 23702, TaiwanInstitute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei 10617, TaiwanInstitute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei 10617, TaiwanInstitute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei 10617, TaiwanOxidative stress and later-induced chronic inflammation have been reported to play an important role on the progression of sarcopenia. Current treatments for sarcopenia are mainly administered to patients whom sarcopenia already developed. However, there has been no promising results shown in therapy. Therefore, the development of therapeutic and preventive strategies against sarcopenia would be necessary. Curcumin is a traditional medicine that possesses anti-inflammatory and antioxidative properties. In the present study, hydroxyapatite was subjected to hydrophobic surface modifications for curcumin loading (Cur-SHAP). It was, subsequently, utilized for delivery to the patient’s body via intramuscular injection in order to achieve constant release for more than 2 weeks, preventing the progression of the sarcopenia or even leading to recovery from the early stage of the illness. According to the results of WST-1, LIVE/DEAD, DCFDA, and gene expression assays, Cur-SHAP exhibited good biocompatibility and showed great antioxidant/anti-inflammatory effects through the endocytic pathway. The results of the animal studies showed that the muscle endurance, grip strength, and fat/lean mass ratio were all improved in Cur-SHAP-treated rats from LPS-induced sarcopenia. In summary, we successfully synthesized hydrophobic surface modification hydroxyapatite for curcumin loading (Cur-SHAP) and drug delivery via the IM route. The LPS-induced sarcopenia rats were able to recover from disease after the Cur-SHAP treatment.https://www.mdpi.com/2076-3921/10/4/616sarcopeniaantioxidantcurcuminhydroxyapatitedrug delivery |
| spellingShingle | Ya-Jyun Liang I-Hsuan Yang Yi-Wen Lin Jhih-Ni Lin Chang-Chin Wu Chih-Yung Chiang Kun-Hung Lai Feng-Huei Lin Curcumin-Loaded Hydrophobic Surface-Modified Hydroxyapatite as an Antioxidant for Sarcopenia Prevention Antioxidants sarcopenia antioxidant curcumin hydroxyapatite drug delivery |
| title | Curcumin-Loaded Hydrophobic Surface-Modified Hydroxyapatite as an Antioxidant for Sarcopenia Prevention |
| title_full | Curcumin-Loaded Hydrophobic Surface-Modified Hydroxyapatite as an Antioxidant for Sarcopenia Prevention |
| title_fullStr | Curcumin-Loaded Hydrophobic Surface-Modified Hydroxyapatite as an Antioxidant for Sarcopenia Prevention |
| title_full_unstemmed | Curcumin-Loaded Hydrophobic Surface-Modified Hydroxyapatite as an Antioxidant for Sarcopenia Prevention |
| title_short | Curcumin-Loaded Hydrophobic Surface-Modified Hydroxyapatite as an Antioxidant for Sarcopenia Prevention |
| title_sort | curcumin loaded hydrophobic surface modified hydroxyapatite as an antioxidant for sarcopenia prevention |
| topic | sarcopenia antioxidant curcumin hydroxyapatite drug delivery |
| url | https://www.mdpi.com/2076-3921/10/4/616 |
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