Epidemiological profile of acute kidney injury in critically ill patients admitted to intensive care units: A Prospective Brazilian Cohort
Abstract Introduction Acute kidney injury (AKI) is a frequent syndrome affecting patients admitted to intensive care units (ICU), and it is associated with poor clinical outcomes. The aim of the present study was to understand the epidemiological profile of patients with AKI admitted to ICUs. Meth...
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| Format: | Article |
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Sociedade Brasileira de Nefrologia
2021-03-01
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| Series: | Brazilian Journal of Nephrology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002021000400580&tlng=en |
| _version_ | 1818730993554554880 |
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| author | Antônio José Inda-Filho Heitor Siqueira Ribeiro Edilene Almeida Vieira Aparecido Pimentel Ferreira |
| author_facet | Antônio José Inda-Filho Heitor Siqueira Ribeiro Edilene Almeida Vieira Aparecido Pimentel Ferreira |
| author_sort | Antônio José Inda-Filho |
| collection | DOAJ |
| description | Abstract Introduction Acute kidney injury (AKI) is a frequent syndrome affecting patients admitted to intensive care units (ICU), and it is associated with poor clinical outcomes. The aim of the present study was to understand the epidemiological profile of patients with AKI admitted to ICUs. Methods Prospective cohort study, carried out in three ICUs in the Federal District, Brazil. Between October/2017 and December/2018, 8,131 patients were included in the cohort. AKI was defined according to the KDIGO criteria. The main outcomes assessed were AKI development and mortality within 28 days of hospitalization. Results Of the 8,131 patients followed up, 1,728 developed AKI (21.3%). Of the 1,728 patients with AKI, 1,060 (61.3%) developed stage 1, while stages 2 and 3 represented 154 (8.9%) and 514 (29.7%), respectively. Of these, 459 (26.6%) underwent renal replacement therapy. The mortality was 25.7% for those with AKI, and 4.9% for those without AKI. Discussion Patients with AKI had higher mortality rates when compared to those without AKI. Likewise, among patients with AKI, higher disease stages were associated with higher death occurrences. AKI incidence (21.3%) and mortality (25.7%) in our study is in line with the largest meta-analysis ever conducted, in which incidence and mortality of 21.6 and 23.9% were observed, respectively. These findings confirm the importance of establishing the KDIGO guideline for the definition and management of AKI in Brazilian ICUs. |
| first_indexed | 2024-12-17T23:10:36Z |
| format | Article |
| id | doaj.art-b1c02bbb48b945068f9643e8eac93405 |
| institution | Directory Open Access Journal |
| issn | 2175-8239 |
| language | English |
| last_indexed | 2024-12-17T23:10:36Z |
| publishDate | 2021-03-01 |
| publisher | Sociedade Brasileira de Nefrologia |
| record_format | Article |
| series | Brazilian Journal of Nephrology |
| spelling | doaj.art-b1c02bbb48b945068f9643e8eac934052022-12-21T21:29:08ZengSociedade Brasileira de NefrologiaBrazilian Journal of Nephrology2175-82392021-03-0143458058510.1590/2175-8239-jbn-2020-0191Epidemiological profile of acute kidney injury in critically ill patients admitted to intensive care units: A Prospective Brazilian CohortAntônio José Inda-Filhohttps://orcid.org/0000-0003-1252-180XHeitor Siqueira Ribeirohttps://orcid.org/0000-0002-4019-4490Edilene Almeida VieiraAparecido Pimentel Ferreirahttps://orcid.org/0000-0002-0069-1206Abstract Introduction Acute kidney injury (AKI) is a frequent syndrome affecting patients admitted to intensive care units (ICU), and it is associated with poor clinical outcomes. The aim of the present study was to understand the epidemiological profile of patients with AKI admitted to ICUs. Methods Prospective cohort study, carried out in three ICUs in the Federal District, Brazil. Between October/2017 and December/2018, 8,131 patients were included in the cohort. AKI was defined according to the KDIGO criteria. The main outcomes assessed were AKI development and mortality within 28 days of hospitalization. Results Of the 8,131 patients followed up, 1,728 developed AKI (21.3%). Of the 1,728 patients with AKI, 1,060 (61.3%) developed stage 1, while stages 2 and 3 represented 154 (8.9%) and 514 (29.7%), respectively. Of these, 459 (26.6%) underwent renal replacement therapy. The mortality was 25.7% for those with AKI, and 4.9% for those without AKI. Discussion Patients with AKI had higher mortality rates when compared to those without AKI. Likewise, among patients with AKI, higher disease stages were associated with higher death occurrences. AKI incidence (21.3%) and mortality (25.7%) in our study is in line with the largest meta-analysis ever conducted, in which incidence and mortality of 21.6 and 23.9% were observed, respectively. These findings confirm the importance of establishing the KDIGO guideline for the definition and management of AKI in Brazilian ICUs.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002021000400580&tlng=enAcute Kidney InjuryIntensive Care UnitsEpidemiologyNephrology |
| spellingShingle | Antônio José Inda-Filho Heitor Siqueira Ribeiro Edilene Almeida Vieira Aparecido Pimentel Ferreira Epidemiological profile of acute kidney injury in critically ill patients admitted to intensive care units: A Prospective Brazilian Cohort Brazilian Journal of Nephrology Acute Kidney Injury Intensive Care Units Epidemiology Nephrology |
| title | Epidemiological profile of acute kidney injury in critically ill patients admitted to intensive care units: A Prospective Brazilian Cohort |
| title_full | Epidemiological profile of acute kidney injury in critically ill patients admitted to intensive care units: A Prospective Brazilian Cohort |
| title_fullStr | Epidemiological profile of acute kidney injury in critically ill patients admitted to intensive care units: A Prospective Brazilian Cohort |
| title_full_unstemmed | Epidemiological profile of acute kidney injury in critically ill patients admitted to intensive care units: A Prospective Brazilian Cohort |
| title_short | Epidemiological profile of acute kidney injury in critically ill patients admitted to intensive care units: A Prospective Brazilian Cohort |
| title_sort | epidemiological profile of acute kidney injury in critically ill patients admitted to intensive care units a prospective brazilian cohort |
| topic | Acute Kidney Injury Intensive Care Units Epidemiology Nephrology |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002021000400580&tlng=en |
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