Novel Biopolymer-Based Composite Wound Healing Wafers Containing Astragalus sarcocolla Gum

The aim of this research was the formulation development, optimisation and characterisation of wafers produced from various combinations of carrageenan and tragacanth gum as potential carriers for wound healing extracts. Gels composed of one of the following three polymers: carrageenan (CAR), traga...

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Main Authors: Nessa Bayat, Joshua S Boateng
Format: Article
Language:English
Published: University of Huddersfield Press 2022-11-01
Series:British Journal of Pharmacy
Online Access:https://www.bjpharm.org.uk/article/id/1154/
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author Nessa Bayat
Joshua S Boateng
author_facet Nessa Bayat
Joshua S Boateng
author_sort Nessa Bayat
collection DOAJ
description The aim of this research was the formulation development, optimisation and characterisation of wafers produced from various combinations of carrageenan and tragacanth gum as potential carriers for wound healing extracts. Gels composed of one of the following three polymers: carrageenan (CAR), tragacanth gum (TG) and hydroxypropyl methylcellulose (HPMC) were prepared and freeze dried to obtain single polymer blank wafers. The blank wafers were examined for required lyophilisation behaviour and physical elegance of the resulting product. Based on these results, HPMC was eliminated and a combination of CAR:TG at seven different polymer ratios was chosen for further research. These CAR:TG wafers were characterised using scanning electron microscope (SEM), X-ray diffraction(XRD), texture analysis (hardness and mucoadhesion), Fourier transform infraredspectroscopy (FTIR), swelling tests and fluid handling properties. The formulations with the optimal properties were selected for loading with the extract and the drug-loaded wafers were subsequently further characterised as above.
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spelling doaj.art-b1c08f293d68402393b651bee6e7471d2023-05-17T13:58:47ZengUniversity of Huddersfield PressBritish Journal of Pharmacy2058-83562022-11-017210.5920/bjpharm.1154Novel Biopolymer-Based Composite Wound Healing Wafers Containing Astragalus sarcocolla GumNessa Bayat 0Joshua S BoatengGreenwich UniversityThe aim of this research was the formulation development, optimisation and characterisation of wafers produced from various combinations of carrageenan and tragacanth gum as potential carriers for wound healing extracts. Gels composed of one of the following three polymers: carrageenan (CAR), tragacanth gum (TG) and hydroxypropyl methylcellulose (HPMC) were prepared and freeze dried to obtain single polymer blank wafers. The blank wafers were examined for required lyophilisation behaviour and physical elegance of the resulting product. Based on these results, HPMC was eliminated and a combination of CAR:TG at seven different polymer ratios was chosen for further research. These CAR:TG wafers were characterised using scanning electron microscope (SEM), X-ray diffraction(XRD), texture analysis (hardness and mucoadhesion), Fourier transform infraredspectroscopy (FTIR), swelling tests and fluid handling properties. The formulations with the optimal properties were selected for loading with the extract and the drug-loaded wafers were subsequently further characterised as above. https://www.bjpharm.org.uk/article/id/1154/
spellingShingle Nessa Bayat
Joshua S Boateng
Novel Biopolymer-Based Composite Wound Healing Wafers Containing Astragalus sarcocolla Gum
British Journal of Pharmacy
title Novel Biopolymer-Based Composite Wound Healing Wafers Containing Astragalus sarcocolla Gum
title_full Novel Biopolymer-Based Composite Wound Healing Wafers Containing Astragalus sarcocolla Gum
title_fullStr Novel Biopolymer-Based Composite Wound Healing Wafers Containing Astragalus sarcocolla Gum
title_full_unstemmed Novel Biopolymer-Based Composite Wound Healing Wafers Containing Astragalus sarcocolla Gum
title_short Novel Biopolymer-Based Composite Wound Healing Wafers Containing Astragalus sarcocolla Gum
title_sort novel biopolymer based composite wound healing wafers containing astragalus sarcocolla gum
url https://www.bjpharm.org.uk/article/id/1154/
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