Anaplastic Variant of Classical Seminoma of the Testis: Northern Israel Oncology Center Experience and Brief Review of Literature
Objectives: There are only sporadic reports on the clinical behavior and appropriate treatment of anaplastic seminoma. This retrospective study summarizes our experience with the anaplastic variant of classical (typical) seminoma. Methods: Between 1986 and 2006, seven anaplastic seminoma patients...
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| Format: | Article |
| Language: | English |
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Rambam Health Care Campus
2014-01-01
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| Series: | Rambam Maimonides Medical Journal |
| Subjects: | |
| Online Access: | http://rmmj.org.il/Pages/ArticleHTM.aspx?manuId=358 |
| _version_ | 1819295752096055296 |
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| author | Moshe E. Stein Jamal Zidan Tomer Charas Karen Drumea Rahamim Ben-Yosef |
| author_facet | Moshe E. Stein Jamal Zidan Tomer Charas Karen Drumea Rahamim Ben-Yosef |
| author_sort | Moshe E. Stein |
| collection | DOAJ |
| description | Objectives: There are only sporadic reports on the clinical behavior and appropriate treatment of anaplastic seminoma. This retrospective study summarizes our experience with the anaplastic variant of classical (typical) seminoma.
Methods: Between 1986 and 2006, seven anaplastic seminoma patients were staged and treated at the Northern Israel Oncology Center. Staging procedures included meticulous physical and neurological examinations, complete blood count, full biochemistry profile, specific tumor markers, testicular ultrasound, and other radiological measures. All patients underwent inguinal orchiectomy and were staged properly. Six patients had stage I disease, and one patient had stage IIA disease. Patients were irradiated with doses ranging from 2,500 to 3,000 cGy, and the stage IIA patient received an additional 1,000 cGy boost to radiographically involved lymph nodes.
Results: After a mean follow-up of 11 years, six patients are alive with no evidence of disease. One patient died due to an unknown, non-oncological, cause, unrelated to his previous testicular tumor, while in complete remission.
Conclusions: Despite the low patient numbers and the retrospective nature of our study, it can be concluded that radiotherapy treatment for early-stage anaplastic seminoma patients might achieve the same excellent survival as for classical seminoma. However, the general consensus achieved through large-scale studies suggests that active surveillance should be offered to all stage I seminoma patients, regardless of the pathologic variant. |
| first_indexed | 2024-12-24T04:47:12Z |
| format | Article |
| id | doaj.art-b1c0aa67040b43d0a3e6dde9905e76e1 |
| institution | Directory Open Access Journal |
| issn | 2076-9172 |
| language | English |
| last_indexed | 2024-12-24T04:47:12Z |
| publishDate | 2014-01-01 |
| publisher | Rambam Health Care Campus |
| record_format | Article |
| series | Rambam Maimonides Medical Journal |
| spelling | doaj.art-b1c0aa67040b43d0a3e6dde9905e76e12022-12-21T17:14:40ZengRambam Health Care CampusRambam Maimonides Medical Journal2076-91722014-01-0151e000610.5041/RMMJ.10140Anaplastic Variant of Classical Seminoma of the Testis: Northern Israel Oncology Center Experience and Brief Review of LiteratureMoshe E. Stein0Jamal Zidan1Tomer Charas2Karen Drumea3Rahamim Ben-Yosef4Northern Israel Oncology Center, Rambam Health Care Campus, and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel andInstitute of Oncology, Ziv Medical Center, Safed, IsraelNorthern Israel Oncology Center, Rambam Health Care Campus, and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel andNorthern Israel Oncology Center, Rambam Health Care Campus, and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel andNorthern Israel Oncology Center, Rambam Health Care Campus, and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel andObjectives: There are only sporadic reports on the clinical behavior and appropriate treatment of anaplastic seminoma. This retrospective study summarizes our experience with the anaplastic variant of classical (typical) seminoma. Methods: Between 1986 and 2006, seven anaplastic seminoma patients were staged and treated at the Northern Israel Oncology Center. Staging procedures included meticulous physical and neurological examinations, complete blood count, full biochemistry profile, specific tumor markers, testicular ultrasound, and other radiological measures. All patients underwent inguinal orchiectomy and were staged properly. Six patients had stage I disease, and one patient had stage IIA disease. Patients were irradiated with doses ranging from 2,500 to 3,000 cGy, and the stage IIA patient received an additional 1,000 cGy boost to radiographically involved lymph nodes. Results: After a mean follow-up of 11 years, six patients are alive with no evidence of disease. One patient died due to an unknown, non-oncological, cause, unrelated to his previous testicular tumor, while in complete remission. Conclusions: Despite the low patient numbers and the retrospective nature of our study, it can be concluded that radiotherapy treatment for early-stage anaplastic seminoma patients might achieve the same excellent survival as for classical seminoma. However, the general consensus achieved through large-scale studies suggests that active surveillance should be offered to all stage I seminoma patients, regardless of the pathologic variant.http://rmmj.org.il/Pages/ArticleHTM.aspx?manuId=358Anaplastic seminomaearly stagegood prognosisradiotherapy |
| spellingShingle | Moshe E. Stein Jamal Zidan Tomer Charas Karen Drumea Rahamim Ben-Yosef Anaplastic Variant of Classical Seminoma of the Testis: Northern Israel Oncology Center Experience and Brief Review of Literature Rambam Maimonides Medical Journal Anaplastic seminoma early stage good prognosis radiotherapy |
| title | Anaplastic Variant of Classical Seminoma of the Testis: Northern Israel Oncology Center Experience and Brief Review of Literature |
| title_full | Anaplastic Variant of Classical Seminoma of the Testis: Northern Israel Oncology Center Experience and Brief Review of Literature |
| title_fullStr | Anaplastic Variant of Classical Seminoma of the Testis: Northern Israel Oncology Center Experience and Brief Review of Literature |
| title_full_unstemmed | Anaplastic Variant of Classical Seminoma of the Testis: Northern Israel Oncology Center Experience and Brief Review of Literature |
| title_short | Anaplastic Variant of Classical Seminoma of the Testis: Northern Israel Oncology Center Experience and Brief Review of Literature |
| title_sort | anaplastic variant of classical seminoma of the testis northern israel oncology center experience and brief review of literature |
| topic | Anaplastic seminoma early stage good prognosis radiotherapy |
| url | http://rmmj.org.il/Pages/ArticleHTM.aspx?manuId=358 |
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