Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology
Background: Coronavirus (Covid-19) infection represents a serious medical condition, often associated with cardiovascular complications, pulmonary hypertension (PH), and right ventricle dysfunction (RVD). The aim of this study is to show, by means of transthoracic echocardiography (TTE), the presenc...
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MDPI AG
2021-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/2/199 |
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| author | Cristina Tudoran Mariana Tudoran Voichita Elena Lazureanu Adelina Raluca Marinescu Gheorghe Nicusor Pop Alexandru Silvius Pescariu Alexandra Enache Talida Georgiana Cut |
| author_facet | Cristina Tudoran Mariana Tudoran Voichita Elena Lazureanu Adelina Raluca Marinescu Gheorghe Nicusor Pop Alexandru Silvius Pescariu Alexandra Enache Talida Georgiana Cut |
| author_sort | Cristina Tudoran |
| collection | DOAJ |
| description | Background: Coronavirus (Covid-19) infection represents a serious medical condition, often associated with cardiovascular complications, pulmonary hypertension (PH), and right ventricle dysfunction (RVD). The aim of this study is to show, by means of transthoracic echocardiography (TTE), the presence of an increased estimated systolic pressure in the pulmonary artery (esPAP) and altered right ventricular global longitudinal strain (RV-GLS) in patients without history of PH. Methods: In a group of 91 patients, aged under 55 years, hospitalized for a moderate Covid-19 infection, a thorough cardiologic and TTE examination were performed two months after discharge. Their initial thorax computer-tomography (TCT) images and laboratory data were accessed from the electronic data base of the hospital. Results: We observed an increased prevalence of PH (7.69%) and RVD (10.28%), significantly correlated with the initial levels of the TCT score and inflammatory factors (<i>p</i> ˂ 0.001), but borderline changes were observed in more patients. Multivariate regression analysis showed that these factors and RV-GLS explain 89.5% of elevated esPAP. Conclusions: In COVID-19 infection, PH and RVD are common complications, being encountered after the recovery even in moderate cases. It appears to be a connection between their severity and the extent of the initial pulmonary injury and of the inflammatory response. |
| first_indexed | 2024-03-09T05:42:26Z |
| format | Article |
| id | doaj.art-b1c14f2ffd284879968647e9c451ad2b |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T05:42:26Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-b1c14f2ffd284879968647e9c451ad2b2023-12-03T12:24:09ZengMDPI AGJournal of Clinical Medicine2077-03832021-01-0110219910.3390/jcm10020199Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular PathologyCristina Tudoran0Mariana Tudoran1Voichita Elena Lazureanu2Adelina Raluca Marinescu3Gheorghe Nicusor Pop4Alexandru Silvius Pescariu5Alexandra Enache6Talida Georgiana Cut7Department VII, Internal Medicine II, Discipline of Cardiology, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaDepartment VII, Internal Medicine II, Discipline of Cardiology, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaDepartment XIII, Discipline of Infectious Diseases, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaDepartment XIII, Discipline of Infectious Diseases, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaUniversity of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaUniversity of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaDepartment VIII, Discipline of Forensic Medicine, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaUniversity of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaBackground: Coronavirus (Covid-19) infection represents a serious medical condition, often associated with cardiovascular complications, pulmonary hypertension (PH), and right ventricle dysfunction (RVD). The aim of this study is to show, by means of transthoracic echocardiography (TTE), the presence of an increased estimated systolic pressure in the pulmonary artery (esPAP) and altered right ventricular global longitudinal strain (RV-GLS) in patients without history of PH. Methods: In a group of 91 patients, aged under 55 years, hospitalized for a moderate Covid-19 infection, a thorough cardiologic and TTE examination were performed two months after discharge. Their initial thorax computer-tomography (TCT) images and laboratory data were accessed from the electronic data base of the hospital. Results: We observed an increased prevalence of PH (7.69%) and RVD (10.28%), significantly correlated with the initial levels of the TCT score and inflammatory factors (<i>p</i> ˂ 0.001), but borderline changes were observed in more patients. Multivariate regression analysis showed that these factors and RV-GLS explain 89.5% of elevated esPAP. Conclusions: In COVID-19 infection, PH and RVD are common complications, being encountered after the recovery even in moderate cases. It appears to be a connection between their severity and the extent of the initial pulmonary injury and of the inflammatory response.https://www.mdpi.com/2077-0383/10/2/199COVID-19thorax CT COVID scorepulmonary hypertensionestimates systolic pulmonary pressureright ventricle global longitudinal strain |
| spellingShingle | Cristina Tudoran Mariana Tudoran Voichita Elena Lazureanu Adelina Raluca Marinescu Gheorghe Nicusor Pop Alexandru Silvius Pescariu Alexandra Enache Talida Georgiana Cut Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology Journal of Clinical Medicine COVID-19 thorax CT COVID score pulmonary hypertension estimates systolic pulmonary pressure right ventricle global longitudinal strain |
| title | Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology |
| title_full | Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology |
| title_fullStr | Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology |
| title_full_unstemmed | Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology |
| title_short | Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology |
| title_sort | evidence of pulmonary hypertension after sars cov 2 infection in subjects without previous significant cardiovascular pathology |
| topic | COVID-19 thorax CT COVID score pulmonary hypertension estimates systolic pulmonary pressure right ventricle global longitudinal strain |
| url | https://www.mdpi.com/2077-0383/10/2/199 |
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