Involvement of Epithelial-Mesenchymal Transition (EMT) in Autoimmune Diseases
Epithelial-mesenchymal transition (EMT) is a complex reversible biological process characterized by the loss of epithelial features and the acquisition of mesenchymal features. EMT was initially described in developmental processes and was further associated with pathological conditions including me...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/19/14481 |
| _version_ | 1797575839191138304 |
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| author | Julie Sarrand Muhammad S. Soyfoo |
| author_facet | Julie Sarrand Muhammad S. Soyfoo |
| author_sort | Julie Sarrand |
| collection | DOAJ |
| description | Epithelial-mesenchymal transition (EMT) is a complex reversible biological process characterized by the loss of epithelial features and the acquisition of mesenchymal features. EMT was initially described in developmental processes and was further associated with pathological conditions including metastatic cascade arising in neoplastic progression and organ fibrosis. Fibrosis is delineated by an excessive number of myofibroblasts, resulting in exuberant production of extracellular matrix (ECM) proteins, thereby compromising organ function and ultimately leading to its failure. It is now well acknowledged that a significant number of myofibroblasts result from the conversion of epithelial cells via EMT. Over the past two decades, evidence has accrued linking fibrosis to many chronic autoimmune and inflammatory diseases, including systemic sclerosis (SSc), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sjögren’s syndrome (SS), and inflammatory bowel diseases (IBD). In addition, chronic inflammatory states observed in most autoimmune and inflammatory diseases can act as a potent trigger of EMT, leading to the development of a pathological fibrotic state. In the present review, we aim to describe the current state of knowledge regarding the contribution of EMT to the pathophysiological processes of various rheumatic conditions. |
| first_indexed | 2024-03-10T21:43:57Z |
| format | Article |
| id | doaj.art-b1c900a22913411a9f2effe9c7764384 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T21:43:57Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b1c900a22913411a9f2effe9c77643842023-11-19T14:27:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124191448110.3390/ijms241914481Involvement of Epithelial-Mesenchymal Transition (EMT) in Autoimmune DiseasesJulie Sarrand0Muhammad S. Soyfoo1Department of Rheumatology, Hôpital Erasme, Université Libre de Bruxelles, 1070 Brussels, BelgiumDepartment of Rheumatology, Hôpital Erasme, Université Libre de Bruxelles, 1070 Brussels, BelgiumEpithelial-mesenchymal transition (EMT) is a complex reversible biological process characterized by the loss of epithelial features and the acquisition of mesenchymal features. EMT was initially described in developmental processes and was further associated with pathological conditions including metastatic cascade arising in neoplastic progression and organ fibrosis. Fibrosis is delineated by an excessive number of myofibroblasts, resulting in exuberant production of extracellular matrix (ECM) proteins, thereby compromising organ function and ultimately leading to its failure. It is now well acknowledged that a significant number of myofibroblasts result from the conversion of epithelial cells via EMT. Over the past two decades, evidence has accrued linking fibrosis to many chronic autoimmune and inflammatory diseases, including systemic sclerosis (SSc), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sjögren’s syndrome (SS), and inflammatory bowel diseases (IBD). In addition, chronic inflammatory states observed in most autoimmune and inflammatory diseases can act as a potent trigger of EMT, leading to the development of a pathological fibrotic state. In the present review, we aim to describe the current state of knowledge regarding the contribution of EMT to the pathophysiological processes of various rheumatic conditions.https://www.mdpi.com/1422-0067/24/19/14481epithelial to mesenchymal transitionfibrosischronic inflammationinnate immunityadaptive immunityrheumatic diseases |
| spellingShingle | Julie Sarrand Muhammad S. Soyfoo Involvement of Epithelial-Mesenchymal Transition (EMT) in Autoimmune Diseases International Journal of Molecular Sciences epithelial to mesenchymal transition fibrosis chronic inflammation innate immunity adaptive immunity rheumatic diseases |
| title | Involvement of Epithelial-Mesenchymal Transition (EMT) in Autoimmune Diseases |
| title_full | Involvement of Epithelial-Mesenchymal Transition (EMT) in Autoimmune Diseases |
| title_fullStr | Involvement of Epithelial-Mesenchymal Transition (EMT) in Autoimmune Diseases |
| title_full_unstemmed | Involvement of Epithelial-Mesenchymal Transition (EMT) in Autoimmune Diseases |
| title_short | Involvement of Epithelial-Mesenchymal Transition (EMT) in Autoimmune Diseases |
| title_sort | involvement of epithelial mesenchymal transition emt in autoimmune diseases |
| topic | epithelial to mesenchymal transition fibrosis chronic inflammation innate immunity adaptive immunity rheumatic diseases |
| url | https://www.mdpi.com/1422-0067/24/19/14481 |
| work_keys_str_mv | AT juliesarrand involvementofepithelialmesenchymaltransitionemtinautoimmunediseases AT muhammadssoyfoo involvementofepithelialmesenchymaltransitionemtinautoimmunediseases |